Title

The dexamethasone suppression test: identification of subtypes of depression

UMMS Affiliation

Department of Psychiatry

Date

1-1-1983

Document Type

Article

Medical Subject Headings

Adolescent; Adult; Aged; Bipolar Disorder; Depressive Disorder; Dexamethasone; Diagnosis, Differential; Female; Humans; Hydrocortisone; Male; Middle Aged

Disciplines

Psychiatry

Abstract

In this study mean 4 p.m. cortisol levels were significantly higher in patients with major depression than in control subjects or in patients with bipolar depression or dysthymic-related disorders. Moreover, the distribution of values differed significantly among groups. Eighteen of 45 patients with major depression had cortisol levels of 10 micrograms/dl or more, compared with 2 of 20 bipolar depressed patients and 0 of 31 controls. Patients with very high cortisol levels (15 micrograms/dl or more) tended to fulfill criteria for major depression with mood-congruent psychosis. The distribution of values in the major depression group also suggested the existence of three major subgroups. The authors discuss the implications of these data.

Rights and Permissions

Citation: Am J Psychiatry. 1983 Jan;140(1):88-91.

Related Resources

Link to Article in PubMed

PubMed ID

6847992