A Comparison of Voxel-Based Morphometry and Volumetry Methods in the Context of the Neural Basis of Aggression

UMMS Affiliation

Department of Psychiatry



Document Type


Medical Subject Headings

Aggression; Frontal Lobe; Mental Disorders


Health Services Research | Mental and Social Health | Psychiatric and Mental Health | Psychiatry | Psychiatry and Psychology


The assumption that voxel-based morphometry (VBM) offers an automated substitution for manually-traced volumetry was subjected to empirical evaluation. Data available from a previous volumetry study (Gansler et al. Psychiatry Research: Neuroimaging 171:145–154, 2009) provided the basis for the current study, which assessed for convergence between the methods. Optimized modulated VBM was used to preprocess images (N  = 40). Gray matter volume and self-reported aggression associations were tested. Results indicate convergence, as both methods revealed significant negative associations of the left orbitofrontal cortex (OFC) and aggression. VBM detected an additional positive left OFC result not revealed with volumetry, suggesting that VBM may allow greater within-region localization than volumetry. However, the methods differentially deal with error rates and power demands and as such are better conceptualized as complementary than interchangeable.

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Emerton, B.C., Jerram, M., Deckersbach, T., Dougherty, D.D., Fulwiler, C., Gansler, D.A. A comparison of voxel-based morphometry and volumetry methods in the context of the neural basis of aggression. Brain Imaging and Behavior, Published online July 1, 2009 (DOI: 10.1007/s11682-009-9075-2).


Volumetry, Voxel-based morphometry, Orbital frontal cortex, Aggression