Hypothalamic lesions and intermittent explosive disorder

UMMS Affiliation

Department of Psychiatry



Document Type


Medical Subject Headings

Adult; Aggression; Craniopharyngioma; Delirium, Dementia, Amnestic, Cognitive; Disorders; Female; Follow-Up Studies; Humans; Hypothalamo-Hypophyseal System; Magnetic Resonance Imaging; Male; Neurologic Examination; Neuropsychological Tests; Pituitary Neoplasms; *Violence


Health Services Research | Mental and Social Health | Psychiatric and Mental Health | Psychiatry | Psychiatry and Psychology


The authors present two cases of patients with craniopharyngiomas who meet the DSM-III-R criteria for intermittent explosive disorder. Episodes of rage developed before and/or after surgery for removal of the craniopharyngioma. Magnetic resonance imaging revealed hypothalamic-hypophyseal involvement. It is suggested that hypothalamic lesions played a major role in the development of aggressive behavior in both cases.

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Citation: J Neuropsychiatry Clin Neurosci. 1992 Winter;4(1):45-50.

Related Resources

Link to Article in PubMed