Cholecystokinin-immunoreactive innervation of the ventromedial hypothalamus in the rat: possible substrate for autonomic regulation of feeding

UMMS Affiliation

Department of Psychiatry



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Medical Subject Headings

Animals; Autonomic Nervous System; Feeding Behavior; Fluorescent Antibody Technique; Male; Neural Pathways; Pons; Rats; Rats, Inbred Strains; Sincalide; Ventromedial Hypothalamic Nucleus


Health Services Research | Mental and Social Health | Psychiatric and Mental Health | Psychiatry | Psychiatry and Psychology


Cholecystokinin octapeptide (CCK) injected into the medial hypothalamus of the rat has been reported to suppress feeding. In this species, the superior lateral parabrachial subnucleus, which predominantly innervates the ventromedial nucleus of the hypothalamus, is composed primarily of CCK-immunoreactive neurons. Combined retrograde tracing using fluorescent dyes and immunofluorescence for CCK confirms that 80-90% of the neurons in the superior lateral parabrachial nucleus which innervate the ventromedial nucleus of the hypothalamus are CCK-positive. This pathway may underlie autonomic regulation of feeding behavior.

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Citation: Neurosci Lett. 1985 Feb 4;53(3):289-96.

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