UMMS Affiliation

Department of Psychiatry



Document Type


Medical Subject Headings

Beneficence; *Clinical Trials as Topic; *Cognition; *Decision Making; Disclosure; Goals; *Human Experimentation; Humans; *Informed Consent; Patient Care; Patient Participation; Patient Satisfaction; Research


Health Services Research | Mental and Social Health | Psychiatric and Mental Health | Psychiatry | Psychiatry and Psychology


Summary Points:

A key component of informed consent to participate in medical research is the understanding that research is not the same as treatment.

However, studies have found that some research participants do not appreciate important differences between research and treatment, a phenomenon called “therapeutic misconception.”

A consistent definition of therapeutic misconception is missing from the literature, and this hinders attempts to define its prevalence or ways to reduce it.

This paper proposes a new definition and describes how it can be operationalized.

Rights and Permissions

Citation: PLoS Med. 2007 Nov 27;4(11):e324. Link to article on publisher's site

Related Resources

Link to Article in PubMed