Title
A new dietary inflammatory index predicts interval changes in serum high-sensitivity C-reactive protein
UMMS Affiliation
Department of Medicine, Division of Cardiovascular Medicine; Clinical and Population Health Research Program; Department of Medicine, Division of Preventive and Behavioral Medicine
Date
10-30-2009
Document Type
Article
Subjects
Adult; Biological Markers; C-Reactive Protein; Diet; Energy Intake; Exercise; Female; Homeostasis; Humans; Inflammation; Interleukin-1; Interleukin-10; Interleukin-4; Interleukin-6; Interviews as Topic; Male; Middle Aged; Reference Values; Search Engine; Sensitivity and Specificity; Tumor Necrosis Factor-alpha
Disciplines
Behavioral Disciplines and Activities | Behavior and Behavior Mechanisms | Community Health and Preventive Medicine | Preventative Medicine
Abstract
Inflammation is associated with a number of chronic conditions, such as cancer and cardiovascular disease. Reducing inflammation may help prevent or treat these conditions. Diet has consistently been shown to modulate inflammation. To facilitate research into the inflammatory effect of diet on health in humans, we sought to develop and validate an Inflammatory Index designed to assess the inflammatory potential of individuals' diets. An Inflammatory Index was developed based on the results of an extensive literature search. Using data from a longitudinal observational study that carefully measured diet and the inflammatory marker, serum high-sensitivity (hs) C-reactive protein (CRP), in approximately 600 adults for 1 y, we conducted analyses to test the effect of Inflammatory Index score on hs-CRP as a continuous and dichotomous (3 mg/L) indicator of inflammatory response, while controlling for important potential confounders. Results based on continuous measures of hs-CRP suggested that an increasing Inflammatory Index score (representing movement toward an antiinflammatory diet) was associated with a decrease in hs-CRP. Analyses using hs-CRP as a dichotomous variable showed that an antiinflammatory diet was associated with a decrease in the odds of an elevated hs-CRP (P = 0.049). The results are consistent with the ability of the Inflammatory Index to predict hs-CRP and provide additional evidence that diet plays a role in the regulation of inflammation, even after careful control of a wide variety of potential confounders.
Rights and Permissions
Citation: J Nutr. 2009 Dec;139(12):2365-72. Epub 2009 Oct 28. Link to article on publisher's site
Related Resources
PubMed ID
19864399
