Department of Medicine, Division of Preventive and Behavioral Medicine; UMass Worcester Prevention Research Center
Clinical Epidemiology | Dietetics and Clinical Nutrition | Epidemiology | Neoplasms | Women's Health
BACKGROUND: Diet modulates inflammation and inflammatory markers have been associated with cancer outcomes. In the Women's Health Initiative, we investigated associations between a dietary inflammatory index (DII) and invasive breast cancer incidence and death.
METHODS: The DII was calculated from a baseline food frequency questionnaire in 122 788 postmenopausal women, enrolled from 1993 to 1998 with no prior cancer, and followed until 29 August 2014. With median follow-up of 16.02 years, there were 7495 breast cancer cases and 667 breast cancer deaths. We used Cox regression to estimate multivariable-adjusted hazards ratios (HRs) and 95% confidence intervals (95% CIs) by DII quintiles (Q) for incidence of overall breast cancer, breast cancer subtypes, and deaths from breast cancer. The lowest quintile (representing the most anti-inflammatory diet) was the reference.
RESULTS: The DII was not associated with incidence of overall breast cancer (HRQ5vsQ1, 0.99; 95% CI, 0.91-1.07; Ptrend=0.83 for overall breast cancer). In a full cohort analysis, a higher risk of death from breast cancer was associated with consumption of more pro-inflammatory diets at baseline, after controlling for multiple potential confounders (HRQ5vsQ1, 1.33; 95% CI, 1.01-1.76; Ptrend=0.03).
CONCLUSIONS: Future studies are needed to examine the inflammatory potential of post-diagnosis diet given the suggestion from the current study that dietary inflammatory potential before diagnosis is related to breast cancer death.
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Citation: Br J Cancer. 2016 May 24;114(11):1277-85. doi: 10.1038/bjc.2016.98. Epub 2016 Apr 21. Link to article on publisher's site
dietary inflammatory index, breast cancer, incidence, mortality, Women’s Health Initiative
Tabung, Fred K.; Steck, Susan E.; Liese, Angela D.; Zhang, Jiajia; Ma, Yunsheng; Caan, Bette J.; Chlebowski, Rowan T.; Freudenheim, Jo L.; Hou, Lifang; Mossavar-Rahmani, Yasmin; Shivappa, Nitin; Vitolins, Mara Z.; Wactawski-Wende, Jean; Ockene, Judith K.; and Hebert, James R., "Association between dietary inflammatory potential and breast cancer incidence and death: results from the Women's Health Initiative" (2016). Preventive and Behavioral Medicine Publications and Presentations. 346.