Title

Body-composition changes in the simian immunodeficiency virus-infected juvenile rhesus macaque

UMMS Affiliation

Department of Medicine, Division of Preventive and Behavioral Medicine

Date

6-1-2004

Document Type

Article

Subjects

Abdomen; Absorptiometry, Photon; Animals; Body Composition; Disease Models, Animal; Immunophenotyping; Longitudinal Studies; *Macaca mulatta; Male; Prospective Studies; RNA, Viral; Regression Analysis; Reverse Transcriptase Polymerase Chain Reaction; Simian Acquired Immunodeficiency Syndrome; Simian immunodeficiency virus; Viral Load

Disciplines

Infectious Disease | Veterinary Infectious Diseases

Abstract

BACKGROUND: Body-composition changes are common in individuals infected with human immunodeficiency virus. The purpose of the present study was to measure, as a model of wasting in acquired immunodeficiency syndrome (AIDS), longitudinal body-composition changes in macaques infected with simian immunodeficiency virus (SIV).

METHODS: Twelve juvenile macaques were inoculated with SIVmac239. Immunologic, virologic, somatometric, and dual-energy x-ray-absorptiometry measurements were performed prospectively every 4 weeks for 72 weeks and were compared to measurements taken from 8 uninfected control macaques.

RESULTS: During the first 4 weeks, body-fat percentage decreased in the SIV-infected macaques while lean-tissue percentage increased; during weeks 4-72, these macaques lost a greater percentage of total fat tissue but had more subcutaneous-fat deposition than did the uninfected control macaques. Just prior to death, the SIV-infected macaques that died (n=7) had a greater loss in body-mass index, abdominal fat, fat tissue, and lean tissue, compared with that in SIV-infected macaques that survived (n=5).

CONCLUSIONS: Body-composition changes in SIV-infected juvenile macaques exhibit 3 phases: during acute infection, loss of body weight from fat tissue; a compensation period during which macaques grow, but at a reduced rate; and a terminal phase, during which tissue is lost from all body compartments. The SIV-infected juvenile macaque provides a useful model for the investigation of wasting in AIDS, particularly for pediatric AIDS wasting.

Rights and Permissions

Citation: J Infect Dis. 2004 Jun 1;189(11):2010-5. Link to article on publisher's site

Comments

At the time of publication, Wenjun Li was not yet affiliated with the University of Massachusetts Medical School.

Related Resources

Link to Article in PubMed

PubMed ID

15143467