Title

Factors contributing to spontaneous Enterocytozoon bieneusi infection in simian immunodeficiency virus-infected macaques

UMMS Affiliation

Department of Medicine, Division of Preventive and Behavioral Medicine

Date

12-12-2006

Document Type

Article

Subjects

Animals; Body Composition; CD4 Lymphocyte Count; Dietary Supplements; Disease Progression; Enterocytozoon; Macaca mulatta; Microsporidiosis; Risk Factors; Simian Acquired Immunodeficiency Syndrome; Viral Load

Disciplines

Immunology and Infectious Disease | Infectious Disease | Veterinary Medicine

Abstract

BACKGROUND: A cohort of SIV-infected macaques had been used to investigate the effect of dietary supplement, immune status, SIV/AIDS disease progression and serum micronutrients levels on spontaneous acquisition of Enterocytozoon bieneusi infection in SIV-infected macaques.

METHODS: Twenty-four SIV-infected macaques were randomized into 2 groups. One group received a vitamin/mineral supplementation and a second group received a placebo. Both groups were examined for E. bieneusi infection.

RESULTS: SIV-infected macaques were more prone to acquire E. bieneusi with the progression of SIV/AIDS, and the increased shedding of infectious spores was directly associated with decreased CD4 lymphocyte and increased circulating SIV, in both supplemented and unsupplemented groups of animals. Dietary supplementation, body composition factors and serum micronutrients levels however had no association with the acquisition of E. bieneusi infection in these animals.

CONCLUSIONS: Acquisition of E. bieneusi infection is related to SIV disease progression, CD4 counts and viral load but independent of changes in body composition and serum micronutrient levels.

Rights and Permissions

Citation: J Med Primatol. 2006 Dec;35(6):352-60. Link to article on publisher's site

Related Resources

Link to Article in PubMed

PubMed ID

17214663