Influence of donor cocaine use on outcome after cardiac transplantation: analysis of the United Network for Organ Sharing Thoracic Registry
Department of Medicine, Division of Preventive and Behavioral Medicine
Adult; Cocaine-Related Disorders; Follow-Up Studies; Heart Transplantation; Humans; Proportional Hazards Models; Registries; Retrospective Studies; Risk Assessment; Survival Rate; *Tissue Donors
Substance Abuse and Addiction | Surgery
Heart transplantation from donors with a history of cocaine abuse remains controversial. Therefore, we examined the consequence of donor cocaine-use history on all-cause mortality and the development of coronary artery disease after heart transplantation. Using the United Network for Organ Sharing Thoracic Registry we identified 9,217 first-time heart-only adult transplant recipients between January 1999 and December 2003, and then divided this cohort into sub-groups based on the reported history of donor cocaine use. Multivariate analysis revealed no difference in mortality or development of coronary artery disease at 1 and 5 years between transplant recipients who received an organ from donors with a history of cocaine use when compared with donors having no history of cocaine use.
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Citation:Brieke A, Krishnamani R, Rocha MJ, Li W, Patten RD, Konstam MA, Patel AR, Udelson JE, Denofrio D. Influence of donor cocaine use on outcome after cardiac transplantation: analysis of the United Network for Organ Sharing Thoracic Registry. J Heart Lung Transplant. 2008 Dec;27(12):1350-2. doi:10.1016/j.healun.2008.08.008. Link to article on publisher's site