Title

Influence of donor cocaine use on outcome after cardiac transplantation: analysis of the United Network for Organ Sharing Thoracic Registry

UMMS Affiliation

Department of Medicine, Division of Preventive and Behavioral Medicine

Date

12-9-2008

Document Type

Article

Subjects

Adult; Cocaine-Related Disorders; Follow-Up Studies; Heart Transplantation; Humans; Proportional Hazards Models; Registries; Retrospective Studies; Risk Assessment; Survival Rate; *Tissue Donors

Disciplines

Substance Abuse and Addiction | Surgery

Abstract

Heart transplantation from donors with a history of cocaine abuse remains controversial. Therefore, we examined the consequence of donor cocaine-use history on all-cause mortality and the development of coronary artery disease after heart transplantation. Using the United Network for Organ Sharing Thoracic Registry we identified 9,217 first-time heart-only adult transplant recipients between January 1999 and December 2003, and then divided this cohort into sub-groups based on the reported history of donor cocaine use. Multivariate analysis revealed no difference in mortality or development of coronary artery disease at 1 and 5 years between transplant recipients who received an organ from donors with a history of cocaine use when compared with donors having no history of cocaine use.

Rights and Permissions

Citation:Brieke A, Krishnamani R, Rocha MJ, Li W, Patten RD, Konstam MA, Patel AR, Udelson JE, Denofrio D. Influence of donor cocaine use on outcome after cardiac transplantation: analysis of the United Network for Organ Sharing Thoracic Registry. J Heart Lung Transplant. 2008 Dec;27(12):1350-2. doi:10.1016/j.healun.2008.08.008. Link to article on publisher's site

Related Resources

Link to Article in PubMed

PubMed ID

19059117