Movement Disorder Society-sponsored revision of the Unified Parkinson's Disease Rating Scale (MDS-UPDRS): scale presentation and clinimetric testing results
Department of Medicine, Division of Preventive and Behavioral Medicine
Adult; Aged; Aged, 80 and over; *Disability Evaluation; Factor Analysis, Statistical; Female; Humans; Male; Middle Aged; Movement Disorders; Neurologic Examination; Parkinson Disease; *Severity of Illness Index; Societies, Medical
Nervous System Diseases
We present a clinimetric assessment of the Movement Disorder Society (MDS)-sponsored revision of the Unified Parkinson's Disease Rating Scale (MDS-UPDRS). The MDS-UDPRS Task Force revised and expanded the UPDRS using recommendations from a published critique. The MDS-UPDRS has four parts, namely, I: Non-motor Experiences of Daily Living; II: Motor Experiences of Daily Living; III: Motor Examination; IV: Motor Complications. Twenty questions are completed by the patient/caregiver. Item-specific instructions and an appendix of complementary additional scales are provided. Movement disorder specialists and study coordinators administered the UPDRS (55 items) and MDS-UPDRS (65 items) to 877 English speaking (78% non-Latino Caucasian) patients with Parkinson's disease from 39 sites. We compared the two scales using correlative techniques and factor analysis. The MDS-UPDRS showed high internal consistency (Cronbach's alpha = 0.79-0.93 across parts) and correlated with the original UPDRS (rho = 0.96). MDS-UPDRS across-part correlations ranged from 0.22 to 0.66. Reliable factor structures for each part were obtained (comparative fit index > 0.90 for each part), which support the use of sum scores for each part in preference to a total score of all parts. The combined clinimetric results of this study support the validity of the MDS-UPDRS for rating PD.
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Citation: Mov Disord. 2008 Nov 15;23(15):2129-70. Link to article on publisher's site
Goetz, Christopher; Tilley, Barbara C.; Shaftman, Stephanie R.; Stebbins, Glenn T.; Fahn, Stanley; Martinez-Martin, Pablo; Poewe, Werner; Sampaio, Cristina; Stern, Matthew B.; Dodel, Richard; Dubois, Bruno; Holloway, Robert; Jankovic, Joseph; Kulisevsky, Jaime; Lang, Anthony E.; Lees, Andrew; Leurgans, Sue; LeWitt, Peter A.; Nyenhuis, David; Olanow, C. Warren; Rascol, Olivier; Schrag, Anette; Teresi, Jeanne A.; van Hilten, Jacobus J.; and LaPelle, Nancy R., "Movement Disorder Society-sponsored revision of the Unified Parkinson's Disease Rating Scale (MDS-UPDRS): scale presentation and clinimetric testing results" (2008). Preventive and Behavioral Medicine Publications and Presentations. 257.