The Program in Molecular Medicine at the University of Massachusetts Medical School was established in a new research building in 1989. Faculty include both clinical investigators and basic scientists, many of whom focus their research on human disease processes. The laboratory groups and core facilities that compose Molecular Medicine represent many disciplines in the bio-medical sciences: biochemistry and molecular biology, cell biology, medicine, immunology, molecular genetics and microbiology, pediatrics, pharmacology, physiology, genomics, bioinformatics and proteomics. This diverse scientific environment makes the Program an exceptional training ground for graduate students and postdoctoral fellows, who in turn contribute much to its vitality and excitement. This collection showcases publications and presentations written by faculty and researchers of the Program in Molecular Medicine.

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Publications from 2014

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Single point mutation in Rabenosyn-5 in a female with intractable seizures and evidence of defective endocytotic trafficking, Sylvia Stockler, Silvia Corvera, David G. Lambright, Kevin E. Fogarty, Ekaterina Nosova, Deborah Marie Leonard, Robert Steinfeld, Cameron Ackerley, Casper Shyr, Nicolas Au, Kathrin Selby, Margot van Allen, Hilary Vallance, Ron Wevers, David Watkins, David Rosenblatt, Colin J. Ross, Elizabeth Conibear, Wyeth Wasserman, and Clara van Karnebeek

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HTT-lowering reverses Huntington's disease immune dysfunction caused by NFkappaB pathway dysregulation, Ulrike Trager, Ralph Andre, Nayana Lahiri, Anna Magnusson-Lind, Andreas Weiss, Stephan Grueninger, Chris McKinnon, Eva Sirinathsinghji, Shira Kahlon, Edith L. Pfister, Roger Moser, Holger Hummerich, Michael Antoniou, Gillian P. Bates, Ruth Luthi-Carter, Mark W. Lowdell, Maria Bjorkqvist, Gary R. Ostroff, Neil Aronin, and Sarah J. Tabrizi

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The Nef-like effect of murine leukemia virus glycosylated gag on HIV-1 infectivity is mediated by its cytoplasmic domain and depends on the AP-2 adaptor complex, Yoshiko Usami, Sergei Popov, and Heinrich G. Gottlinger

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Resistance to vemurafenib resulting from a novel mutation in the BRAFV600E kinase domain, Timothy R. Wagenaar, Leyuan Ma, Benjamin P. Roscoe, Sung Mi Park, Daniel N. Bolon, and Michael R. Green

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Genetic adaptation to diet preserves longevity, Albertha J. M. Walhout

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Circulating microRNA profiles in human patients with acetaminophen hepatotoxicity or ischemic hepatitis, Jeanine Ward, Chitra Kanchagar, Isana Veksler-Lublinsky, Rosalind C. Lee, Mitchell R. McGill, Hartmut Jaeschke, Steven C. Curry, and Victor R. Ambros

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Evolutionary dynamics and tissue specificity of human long noncoding RNAs in six mammals, Stefan Washietl, Manolis Kellis, and Manuel Garber

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Interspecies Systems Biology Uncovers Metabolites Affecting C. elegans Gene Expression and Life History Traits, Emma Watson, Lesley T. MacNeil, Ashlyn D. Ritter, L. Safak Yilmaz, Adam P. Rosebrock, Amy A. Caudy, and Albertha J. M. Walhout

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Caenorhabditis elegans metabolic gene regulatory networks govern the cellular economy, Emma Watson and Albertha J. M. Walhout

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Determination and inference of eukaryotic transcription factor sequence specificity, Matthew T. Weirauch, Ally Yang, Mihai Albu, Atina G. Cote, Alejandro Montenegro-Montero, Philipp Drewe, Hamed S. Najafabadi, Samuel A. Lambert, Ishminder Mann, Kate Cook, Hong Zheng, Alejandra Goity, Harm van Bakel, Jean-Claude Lozano, Mary Galli, Mathew G. Lewsey, Eryong Huang, Tuhin Mukherjee, Xiaoting Chen, John S. Reece-Hoyes, Sridhar Govindarajan, Gad Shaulsky, Albertha J. M. Walhout, Francois-Yves Bouget, Gunnar Ratsch, Luis F. Larrondo, Joseph R. Ecker, and Timothy R. Hughes

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Worms, bacteria, and micronutrients: an elegant model of our diet, L. Safak Yilmaz and Albertha J. M. Walhout

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Antisense piRNA amplification, but not piRNA production or nuage assembly, requires the Tudor-domain protein Qin, Zhao Zhang, Birgit S. Koppetsch, Jie Wang, Cindy Tipping, Zhiping Weng, William E. Theurkauf, and Phillip D. Zamore

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The HP1 homolog rhino anchors a nuclear complex that suppresses piRNA precursor splicing, Zhao Zhang, Jie Wang, Nadine McGinnis-Schultz, Fan Zhang, Swapnil S. Parhad, Shikui Tu, Thom Vreven, Phillip D. Zamore, Zhiping Weng, and William E. Theurkauf

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TEMP: a computational method for analyzing transposable element polymorphism in populations, Jiali Zhuang, Jie Wang, William E. Theurkauf, and Zhiping Weng

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CRISPRseek: A Bioconductor Package to Identify Target-Specific Guide RNAs for CRISPR-Cas9 Genome-Editing Systems, Lihua Julie Zhu, Benjamin R. Holmes, Neil Aronin, and Michael H. Brodsky

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Mutations in conserved residues of the C. elegans microRNA Argonaute ALG-1 identify separable functions in ALG-1 miRISC loading and target repression, Anna Y. Zinovyeva, Samir Bouasker, Martin J. Simard, Christopher M. Hammell, and Victor R. Ambros

Publications from 2013

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Nucleosome dynamics regulates DNA processing, Nicholas L. Adkins, Hengyao Niu, Patrick Sung, and Craig L. Peterson

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Victor Ambros: the broad scope of microRNAs. Interview by Caitlin Sedwick, Victor R. Ambros

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Gene silencing in adipose tissue macrophages regulates whole-body metabolism in obese mice, Myriam Aouadi, Michaela Tencerova, Pranitha Vangala, Joseph Yawe, Sarah M. Nicoloro, Shinya U. Amano, Jessica L. Cohen, and Michael P. Czech

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The decapping scavenger enzyme DCS-1 controls microRNA levels in Caenorhabditis elegans, Gabriel D. Bosse, Stefan Ruegger, Maria C. Ow, Alejandro Vasquez-Rifo, Evelyne L. Rondeau, Victor R. Ambros, Helge Grosshans, and Martin J. Simard

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Humanized mice for the study of infectious diseases, Michael A. Brehm, Nathalie Jouvet, Dale L. Greiner, and Leonard D. Shultz

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Overcoming current limitations in humanized mouse research, Michael A. Brehm, Leonard D. Shultz, Jeremy Luban, and Dale L. Greiner

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Resurrecting remnants: the lives of post-mitotic midbodies, Chun-Ting Chen, Andreas W. Ettinger, Wieland B. Huttner, and Stephen J. Doxsey

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Gudu, an Armadillo repeat-containing protein, is required for spermatogenesis in Drosophila, Wei Cheng, Y. Tony Ip, and Zuoshang Xu

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Hdac6 regulates Tip60-p400 function in stem cells, Poshen B. Chen, Jui-Hung Hung, Taylor L. Hickman, Andrew H. Coles, James F. Carey, Zhiping Weng, Feixia Chu, and Thomas G. Fazzio

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p16 Stimulates CDC42-Dependent Migration of Hepatocellular Carcinoma Cells, Ya-Wen Chen, Hsiao-Chien Chu, Ze-Shiang Lin, Wei-Jyh Shiah, Chen-Pin Chou, David S. Klimstra, and Brian C. Lewis

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Novel strategies to enhance vaccine immunity against coccidioidomycosis, Garry T. Cole, Chiung-Yu Hung, Sam D. Sanderson, Brady J. Hurtgen, Marcel Wuthrich, Bruce S. Klein, George S. Deepe, Gary R. Ostroff, and Stuart M. Levitz

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Argonautes Promote Male Fertility and Provide a Paternal Memory of Germline Gene Expression in C. elegans, Colin C. Conine, James J. Moresco, Weifeng Gu, Masaki Shirayama, Darryl Conte Jr., John R. Yates III, and Craig C. Mello

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Obesity Notches up fatty liver, Michael P. Czech

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Insulin signalling mechanisms for triacylglycerol storage, Michael P. Czech, Michaela Tencerova, David J. Pedersen, and Myriam Aouadi

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Translational control of cell growth and malignancy by the CPEBs, Andrea D'Ambrogio, Kentaro Nagaoka, and Joel D. Richter

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Map4k4 suppresses Srebp-1 and adipocyte lipogenesis independent of JNK signaling, Laura V. Danai, Adilson L. Guilherme, Kalyani V. P. Guntur, Juerg R. Straubhaar, Sarah M. Nicoloro, and Michael P. Czech

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TNPO3 protects HIV-1 replication from CPSF6-mediated capsid stabilization in the host cell cytoplasm, Alberto De Iaco, Federico A. Santoni, Anne Vannier, Michel Guipponi, Stylianos E. Antonarakis, and Jeremy Luban

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Global analysis of Drosophila Cys2-His2 zinc finger proteins reveals a multitude of novel recognition motifs and binding determinants, Metewo Selase Enuameh, Yuna Asriyan, Adam Richards, Ryan G. Christensen, Victoria L. Hall, Majid Kazemian, Cong Zhu, Hannah Pham, Qiong Cheng, Charles Blatti, Jessie A. Brasefield, Matthew D. Basciotta, Jianhong Ou, Joseph C. McNulty, Lihua Julie Zhu, Susan E. Celniker, Saurabh Sinha, Gary D. Stormo, Michael H. Brodsky, and Scot A. Wolfe

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Toward Understanding the Outer Membrane Uptake of Small Molecules by Pseudomonas aeruginosa, Elif Eren, Jamie Parkin, Ayodele Adelanwa, Belete R. Cheneke, Liviu Movileanu, Syma Khalid, and Bert Van den Berg

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MEN1 is a Melanoma Tumor Suppressor that Preserves Genomic Integrity by Stimulating Transcription of Genes that Promote Homologous Recombination-Directed DNA Repair, Minggang Fang, Fen Xia, Meera Mahalingam, Ching-Man A. Virbasius, Narendra Wajapeyee, and Michael R. Green

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Analysis of ciliary membrane protein dynamics using SNAP technology, John A. Follit and Gregory J. Pazour

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Using networks to measure similarity between genes: association index selection, Juan I. Fuxman Bass, Alos Diallo, Justin Nelson, Juan M. Soto, Chad L. Myers, and Albertha J. M. Walhout

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Dopamine transporter endocytic trafficking in striatal dopaminergic neurons: differential dependence on dynamin and the actin cytoskeleton, Luke Gabriel, Sijia Wu, Patrick Kearney, Karl D. Bellve, Clive Standley, Kevin E. Fogarty, and Haley Melikian

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Apoptosis induced by the fungal pathogen gliotoxin requires a triple phosphorylation of Bim by JNK, A. Geissler, F. Haun, D. O. Frank, K. Wieland, M. M. Simon, M. Idzko, Roger J. Davis, U. Maurer, and C. Borner

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GLI1 regulates a novel neuropilin-2/alpha6beta1 integrin based autocrine pathway that contributes to breast cancer initiation, Hira Lal Goel, Bryan M. Pursell, Cheng Chang, Leslie M. Shaw, Junhao Mao, Karl Simin, Prashant Kumar, Craig W. Vander Kooi, Leonard D. Shultz, Dale L. Greiner, Jens Henrik Norum, Rune Toftgard, Charlotte Kuperwasser, and Arthur M. Mercurio

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beta1 integrins mediate resistance to ionizing radiation in vivo by inhibiting c-Jun amino terminal kinase1, Hira Lal Goel, Aejaz Sayeed, Michael Breen, Matthew J. Zarif, David S. Garlick, Irwin Leav, Roger J. Davis, Thomas J. Fitzgerald, Andea Morrione, Chung-Cheng Hsieh, Qin Liu, Adam P. Dicker, Dario C. Altieri, and Lucia R. Languino

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CD40 Deficiency in Mice Exacerbates Obesity-induced Adipose Tissue Inflammation, Hepatic Steatosis and Insulin Resistance, Chang-An Guo, Sophia Kogan, Shinya U. Amano, Mengxi Wang, Sezin Dagdeviren, Randall H. Friedline, Myriam Aouadi, Jason K. Kim, and Michael P. Czech

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Targeted chromosomal deletions and inversions in zebrafish, Ankit Gupta, Victoria L. Hall, Fatma O. Kok, Masahiro Shin, Joseph C. McNulty, Nathan D. Lawson, and Scot A. Wolfe

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JNK expression by macrophages promotes obesity-induced insulin resistance and inflammation, Myoung Souk Han, Dae Young Jung, Caroline Morel, Saquib A. Lakhani, Jason K. Kim, Richard A. Flavell, and Roger J. Davis

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One among many: ODF2 isoform 9, a.k.a. Cenexin-1, is required for ciliogenesis, Heidi Hehnly, Hui-Fan Hung, and Stephen J. Doxsey

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Cardiac expression of human type 2 iodothyronine deiodinase increases glucose metabolism and protects against doxorubicin-induced cardiac dysfunction in male mice, Eun-Gyoung Hong, Brian W. Kim, Dae Young Jung, Jong Hun Kim, Tim Yu, Wagner Seixas Da Silva, Randall H. Friedline, Suzy D. Bianco, Stephen P. Seslar, Hiroko Wakimoto, Charles I. Berul, Kerry S. Russell, Ki Won Lee, P. Reed Larsen, Antonio C. Bianco, and Jason K. Kim

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Epigenetics in the human brain, Isaac B. Houston, Cyril J. Peter, Amanda C. Mitchell, Juerg R. Straubhaar, Evgeny I. Rogaev, and Schahram Akbarian

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Characterization and optimization of the glucan particle-based vaccine platform, Haibin Huang, Gary R. Ostroff, Chrono K. Lee, Charles A. Specht, and Stuart M. Levitz

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Characterization and optimization of the glucan particle-based vaccine platform, Haibin Huang, Gary R. Ostroff, Chrono K. Lee, Charles A. Specht, and Stuart M. Levitz

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Inductive asymmetric cell division: The WRM leads the way, Takao Ishidate, Soyoung Kim, Craig C. Mello, and Masaki Shirayama

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CD28 and ITK signals regulate autoreactive T cell trafficking, Nitya Jain, Bing Miu, Jian-kang Jiang, Kai K. McKinstry, Amanda L. Prince, Susan L. Swain, Dale L. Greiner, Craig J. Thomas, Michael J. Sanderson, Leslie J. Berg, and Joonso Kang

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Prefrontal cortical dysfunction after overexpression of histone deacetylase 1, Mira Jakovcevski, Rahul Bharadwaj, Juerg R. Straubhaar, Guangping Gao, David P. Gavin, Igor Jakovcevski, Amanda C. Mitchell, and Schahram Akbarian

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U2AF65 adapts to diverse pre-mRNA splice sites through conformational selection of specific and promiscuous RNA recognition motifs, Jermaine L. Jenkins, Anant A. Agrawal, Ankit Gupta, Michael R. Green, and Clara L. Kielkopf

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Functional activity of RLIM/Rnf12 is regulated by phosphorylation-dependent nucleo-cytoplasmic shuttling, Baowei Jiao, Naoko Taniguchi-Ishigaki, Cenap Gungor, Marvin A. Peters, Ya-Wen Chen, Sabine Riethdorf, Alexander Drung, Leanne G. Ahronian, JongDae Shin, Rachna Pagnis, Klaus Pantel, Taro Tachibana, Brian C. Lewis, Steven A. Johnsen, and Ingolf Bach

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Activation of the Nlrp3 inflammasome in infiltrating macrophages by endocannabinoids mediates beta cell loss in type 2 diabetes, Tony Jourdan, Grzegorz Godlewski, Resat Cinar, Adeline Bertola, Gergo Szanda, Jie Liu, Joseph Tam, Tiffany Han, Bani Mukhopadhyay, Monica C. Skarulis, Cynthia Ju, Myriam Aouadi, Michael P. Czech, and George Kunos

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KLF15 is a molecular link between endoplasmic reticulum stress and insulin resistance, Dae Young Jung, UmaDevi Chalasani, Ning Pan, Randall H. Friedline, Domenick A. Prosdocimo, Minwoo Nam, Yoshihiro Azuma, Rajanikanth Maganti, Kristine Yu, Ashish Velagapudi, Bryan O'Sullivan-Murphy, Juliano L. Sartoretto, Mukesh K. Jain, Marcus P. Cooper, Fumihiko Urano, Jason K. Kim, and Susan Gray

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Role of the mixed-lineage protein kinase pathway in the metabolic stress response to obesity, Shashi Kant, Tamera Barrett, Anastassiia Vertii, Yun Hee Noh, Dae Young Jung, Jason K. Kim, and Roger J. Davis

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Widespread evidence of cooperative DNA binding by transcription factors in Drosophila development, Majid Kazemian, Hannah Pham, Scot A. Wolfe, Michael H. Brodsky, and Saurabh Sinha

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Generation of organized anterior foregut epithelia from pluripotent stem cells using small molecules, Nicola A. Kearns, Ryan M. J. Genga, Michael Ziller, Kristina Kapinas, Heiko Peters, Michael A. Brehm, Alexander Meissner, and Rene Maehr

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Wnt and CDK-1 regulate cortical release of WRM-1/beta-catenin to control cell division orientation in early Caenorhabditis elegans embryos, Soyoung Kim, Takao Ishidate, Rita Sharma, Martha C. Soto, Darryl Conte Jr., Craig C. Mello, and Masaki Shirayama

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Engrafted human cells generate adaptive immune responses to Mycobacterium bovis BCG infection in humanized mice, Jinhee Lee, Michael A. Brehm, Dale L. Greiner, Leonard D. Shultz, and Hardy Kornfeld

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Expression of ITGB8 in Epicardial Adipose Tissue is Highly and Directly Correlated with the Severity of Coronary Atherosclerosis, Nancy Lee, Sarah M. Nicoloro, Juerg R. Straubhaar, Melinda Darrigo, Stanley Tam, Michael P. Czech, and Timothy P. Fitzgibbons

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Expression of the Integrin Beta 8 Gene (ITGB8) in Epicardial Adipose Tissue is Highly and Directly Correlated with the Degree of Coronary Atherosclerosis, Nancy Lee, Sarah M. Nicoloro, Juerg R. Straubhaar, Melinda Darrigo, Stanley Tam, Michael P. Czech, and Timothy P. Fitzgibbons

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Analysis of in vitro insulin-resistance models and their physiological relevance to in vivo diet-induced adipose insulin resistance, Kinyui Alice Lo, Adam Labadorf, Norman J. Kennedy, Myoung Souk Han, Yoon Sing Yap, Bryan Matthews, Xiaofeng Xin, Lei Sun, Roger J. Davis, Harvey F. Lodish, and Ernest Fraenkel

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A small molecule inhibitor of fungal histone acetyltransferase Rtt109, Jessica Lopes da Rosa Spiegler, Vineeta Bajaj, James Spoonamore, and Paul D. Kaufman

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Food, pathogen, signal: The multifaceted nature of a bacterial diet, Lesley T. MacNeil and Albertha J. M. Walhout

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Diet-Induced Developmental Acceleration Independent of TOR and Insulin in C. elegans, Lesley T. MacNeil, Emma Watson, H. Efsun Arda, Lihua Julie Zhu, and Albertha J. M. Walhout

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Structural basis for membrane recruitment and allosteric activation of cytohesin family Arf GTPase exchange factors, Andrew W. Malaby, Bert van den Berg, and David G. Lambright

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Loss of cilia suppresses cyst growth in genetic models of autosomal dominant polycystic kidney disease, Ming Ma, Xin Tian, Peter Igarashi, Gregory J. Pazour, and Stefan Somlo

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Releasing the brakes on a chromatin-remodeling enzyme, Benjamin J. Manning and Craig L. Peterson

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The Legionella pneumophila GTPase activating protein LepB accelerates Rab1 deactivation by a non-canonical hydrolytic mechanism, Ashwini K. Mishra, Claudia M. Del Campo, Robert E. Collins, Craig R. Roy, and David G. Lambright

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The Legionella pneumophila GTPase activating protein LepB accelerates Rab1 deactivation by a non-canonical hydrolytic mechanism, Ashwini K. Mishra, Claudia M. Del Campo, Robert E. Collins, Craig R. Roy, and David G. Lambright

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Adipose Tissue Architecture and Gestational Weight Gain in Normoglycemic Pregnancies, Tiffany A. Moore Simas, Olga Gaelekman, Ningning Zhang, Milagros C. Rosal, Mary M. Lee, and Silvia Corvera

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An unusual two-step control of CPEB destruction by Pin1, Morris Nechama, Chien-Ling Lin, and Joel D. Richter

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Survival response to increased ceramide involves metabolic adaptation through novel regulators of glycolysis and lipolysis, Niraj K. Nirala, Motiur Rahman, Stanley M. Walls, Alka Singh, Lihua Julie Zhu, Takeshi Bamba, Eiichiro Fukusaki, Sargur M. Srideshikan, Greg L. Harris, Y. Tony Ip, Rolf Bodmer, and Usha Acharya

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Efficiency of bridging-sheet recruitment explains HIV-1 R5 envelope glycoprotein sensitivity to soluble CD4 and macrophage tropism, Olivia J. O'Connell, Alexander Repik, Jacqueline D. Reeves, Maria Paz Gonzalez-Perez, Briana Quitadamo, Elizabeth D. Anton, Maria J. Duenas-Decamp, Paul J. Peters, Rongheng Lin, Susan Zolla-Pazner, Davide Corti, Aaron Wallace, Shixia Wang, Xiang-Peng Kong, Shan Lu, and Paul R. Clapham

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Efficiency of bridging-sheet recruitment explains HIV-1 R5 envelope glycoprotein sensitivity to soluble CD4 and macrophage tropism, Olivia J. O'Connell, Alexander Repik, Jacqueline D. Reeves, Maria Paz Gonzalez-Perez, Briana Quitadamo, Elizabeth D. Anton, Maria J. Duenas-Decamp, Paul J. Peters, Rongheng Lin, Susan Zolla-Pazner, Davide Corti, Aaron Wallace, Shixia Wang, Xiang-Peng Kong, Shan Lu, and Paul R. Clapham

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Suppression of Gluconeogenic Gene Expression by LSD1-Mediated Histone Demethylation, Dongning Pan, Chunxiao Mao, and Yong-Xu Wang

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Transposition-driven genomic heterogeneity in the Drosophila brain, Paola N. Perrat, Shamik DasGupta, Jie Wang, William E. Theurkauf, Zhiping Weng, Michael Rosbash, and Scott Waddell

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Absence of detectable HIV-1 viremia after treatment cessation in an infant, Deborah Persaud, Hannah Gay, Carrie Ziemniak, Ya Hui Chen, Michael Piatak Jr., Tae-Wook Chun, Matthew Strain, Douglas Richman, and Katherine Ruiz De Luzuriaga

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Nucleosome dynamics as modular systems that integrate DNA damage and repair, Craig L. Peterson and Genevieve Almouzni

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Human immunodeficiency viruses: propagation, quantification, and storage, Paul J. Peters, Kathryn H. Richards, and Paul R. Clapham

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Lv4, an activity that restricts nuclear entry of SIVMAC/SIVSM in human blood cells, Massimo Pizzato, Martha Neagu, Thomas Pertel, Claudia Ferrito, Selena Ziglio, Madeleine Zufferey, Lionel Berthoux, and Jeremy Luban

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Drosophila Myc integrates multiple signaling pathways to regulate intestinal stem cell proliferation during midgut regeneration, Fangfang Ren, Qing Shi, Yongbin Chen, Alice Jiang, Y. Tony Ip, Huaqi Jiang, and Jin Jiang

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Complex expression dynamics and robustness in C. elegans insulin networks, Ashlyn D. Ritter, Yuan Shen, Juan Fuxman Bass, Sankarganesh Jeyaraj, Bart Deplancke, Arnab Mukhopadjay, Jian Xu, Monica Driscoll, Heidi A. Tissenbaum, and Albertha J. M. Walhout

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beta3-Adrenergic receptor stimulation induces E-selectin-mediated adipose tissue inflammation, Rachel J. Roth Flach, Anouch Matevossian, Thomas E. Akie, Kimberly A. Negrin, Marina T. Paul, and Michael P. Czech

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Endocytic transport and cytokinesis: from regulation of the cytoskeleton to midbody inheritance, John Schiel, Carly Childs, and Rytis Prekeris

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UPF1 is Crucial for the Infectivity of Human Immunodeficiency Virus type 1 Progeny Virions, Anna Kristina Serquina, Suman R. Das, Elena Popova, Ogooluwa A. Ojelabi, Christian K. Roy, and Heinrich G. Gottlinger

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The C. elegans CSR-1 argonaute pathway counteracts epigenetic silencing to promote germline gene expression, Meetu Seth, Masaki Shirayama, Weifeng Gu, Takao Ishidate, Darryl Conte Jr., and Craig C. Mello

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Accurate identification of polyadenylation sites from 3' end deep sequencing using a naive Bayes classifier, Sarah E. Sheppard, Nathan D. Lawson, and Lihua Julie Zhu

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Recurrent and recent selective sweeps in the piRNA pathway, Alfred Simkin, Alex Wong, Yu-Ping Poh, William E. Theurkauf, and Jeffrey D. Jensen

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Jumping over the fence: RNA nuclear export revisited, Caterina Strambio-De-Castilla

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Dendritic GluN2A Synthesis Mediates Activity-Induced NMDA Receptor Insertion, Sharon A. Swanger, Yuncan A. He, Joel D. Richter, and Gary J. Bassell

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A compendium of Caenorhabditis elegans RNA binding proteins predicts extensive regulation at multiple levels, Alex M. Tamburino, Sean P. Ryder, and Albertha J. M. Walhout

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Genetic and acute CPEB1 depletion ameliorate fragile X pathophysiology, Tsuyoshi Udagawa, Natalie G. Farny, Mira Jakovcevski, Hanoch Kaphzan, Juan Marcos Alarcon, Shobha Anilkumar, Maria Ivshina, Jessica A. Hurt, Kentaro Nagaoka, Vijayalaxmi C. Nalavadi, Lori J. Lorenz, Gary J. Bassell, Schahram Akbarian, Sumantra Chattarji, Eric Klann, and Joel D. Richter

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HIV-1 Nef responsiveness is determined by Env variable regions involved in trimer association and correlates with neutralization sensitivity, Yoshiko Usami and Heinrich G. Gottlinger

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Diet-induced obesity mediated by the JNK/DIO2 signal transduction pathway, Santiago Vernia, Julie Cavanagh-Kyros, Tamera Barrett, Dae Young Jung, Jason K. Kim, and Roger J. Davis

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C. elegans sirtuins, Mohan Viswanathan and Heidi A. Tissenbaum

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Oncogenic RAS directs silencing of tumor suppressor genes through ordered recruitment of transcriptional repressors, Narendra Wajapeyee, Sunil K. Malonia, Rajendra Kumar Palakurthy, and Michael R. Green