The Program in Molecular Medicine at the University of Massachusetts Medical School was established in a new research building in 1989. Faculty include both clinical investigators and basic scientists, many of whom focus their research on human disease processes. The laboratory groups and core facilities that compose Molecular Medicine represent many disciplines in the bio-medical sciences: biochemistry and molecular biology, cell biology, medicine, immunology, molecular genetics and microbiology, pediatrics, pharmacology, physiology, genomics, bioinformatics and proteomics. This diverse scientific environment makes the Program an exceptional training ground for graduate students and postdoctoral fellows, who in turn contribute much to its vitality and excitement. This collection showcases publications and presentations written by faculty and researchers of the Program in Molecular Medicine.

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Publications from 2015

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Quantitative Correlation of in Vivo Properties with in Vitro Assay Results: The in Vitro Binding of a Biotin-DNA Analogue Modifier with Streptavidin Predicts the in Vivo Avidin-Induced Clearability of the Analogue-Modified Antibody, Shuping Dou, John Virostko, Dale L. Greiner, Alvin C. Powers, and Guozheng Liu

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POS-1 Promotes Endo-mesoderm Development by Inhibiting the Cytoplasmic Polyadenylation of neg-1 mRNA, Ahmed M. Elewa, Masaki Shirayama, Ebru Kaymak, Paul F. Harrison, David R. Powell, Zhuo Du, Christopher D. Chute, Hannah Woolf, Dongni Yi, Takao Ishidate, Jagan Srinivasan, Zhirong Bao, Traude H. Beilharz, Sean P. Ryder, and Craig C. Mello

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The small GTPase Rab8 interacts with VAMP-3 to regulate the delivery of recycling T-cell receptors to the immune synapse, Francesca Finetti, Laura Patrussi, Donatella Galgano, Chiara Cassioli, Giuseppe Perinetti, Gregory J. Pazour, and Cosima T. Baldari

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Human gene-centered transcription factor networks for enhancers and disease variants, Juan Fuxman Bass, Nidhi Sahni, Shaleen Shrestha, Aurian Garcia-Gonzalez, Akihiro Mori, Numana Bhat, Song Yi, David E. Hill, Marc Vidal, and Albertha J. M. Walhout (Cell)

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Viral infection of engrafted human islets leads to diabetes, Glen R. Gallagher, Michael A. Brehm, Robert W. Finberg, Bruce A. Barton, Leonard D. Shultz, Dale L. Greiner, Rita Bortell, and Jennifer P. Wang

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Glycolytic enzymes localize to ribonucleoprotein granules in Drosophila germ cells, bind Tudor and protect from transposable elements, Ming Gao, Travis Thomson, T Michael Creed, Shikui Tu, Sudan N. Loganathan, Christina A. Jackson, Patrick McCluskey, Yanyan Lin, Scott E. Collier, Zhiping Weng, Paul Lasko, Melanie D. Ohi, and Alexey L. Arkov

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Reduced frequencies of polyfunctional CMV-specific T cell responses in infants with congenital CMV infection, Laura L. Gibson, Constance Barysauskas, Margaret M. McManus, Sheryl Dooley, Daniele Lilleri, Donna Fisher, Tumul Srivastava, Don J. Diamond, and Katherine Ruiz De Luzuriaga

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p38alpha MAPK is required for tooth morphogenesis and enamel secretion, Matthew B. Greenblatt, Jung-Min Kim, Hwanhee Oh, Kwang Hwan Park, Min-Kyung Choo, Yasuyo Sano, Coralee E. Tye, Ziedonis Skobe, Roger J. Davis, Jin Mo Park, Marianna Bei, Laurie H. Glimcher, and Jae-Hyuck Shim

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A Gene Expression Signature That Correlates with CD8+ T Cell Expansion in Acute EBV Infection, Thomas C. Greenough, Juerg R. Straubhaar, Larisa Kamga, Eric R. Weiss, Robin M. Brody, Margaret M. McManus, Linda K. Lambrecht, Mohan Somasundaran, and Katherine Ruiz De Luzuriaga

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Influenza A virus preferentially snatches noncoding RNA caps, Weifeng Gu, Glen R. Gallagher, Weiwei Dai, Ping Liu, Ruidong Li, Melanie I. Trombly, Don B. Gammon, Craig C. Mello, Jennifer P. Wang, and Robert W. Finberg

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Regulation of Nucleosome Architecture and Factor Binding Revealed by Nuclease Footprinting of the ESC Genome, Sarah J. Hainer and Thomas G. Fazzio

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Suppression of pervasive noncoding transcription in embryonic stem cells by esBAF, Sarah J. Hainer, Weifeng Gu, Benjamin R. Carone, Benjamin D. Landry, Oliver J. Rando, Craig C. Mello, and Thomas G. Fazzio

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Control of stem cell self-renewal and differentiation by the heterochronic genes and the cellular asymmetry machinery in Caenorhabditis elegans, Omid F. Harandi and Victor R. Ambros

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Transcriptional and post-transcriptional control of adipocyte differentiation by Jumonji domain-containing protein 6, Yu-Jie Hu, Houda Belaghzal, Wen-Yu Hsiao, Jun Qi, James E. Bradner, David A. Guertin, Said Sif, and Anthony N. Imbalzano (Nucleic acids research)

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Poised Regeneration of Zebrafish Melanocytes Involves Direct Differentiation and Concurrent Replenishment of Tissue-Resident Progenitor Cells, Sharanya Iyengar, Melissa Kasheta, and Craig J. Ceol

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Neutrophil Responses to Sterile Implant Materials, Siddharth Jhunjhunwala, Stephanie Aresta-DaSilva, Katherine Tang, David Alvarez, Matthew J. Webber, Benjamin C. Tang, Danya M. Lavin, Omid Veiseh, Joshua C. Doloff, Suman Bose, Arturo Vegas, Minglin Ma, Gaurav Sahay, Alan Chiu, Andrew Bader, Erin Langan, Sean Siebert, Jie Li, Dale L. Greiner, Peter E. Newburger, Ulrich H. von Andrian, Robert Langer, and Daniel G. Anderson

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Safety of Striatal Infusion of siRNA in a Transgenic Huntington's Disease Mouse Model, Emily S. Johnson, Kathryn O. Chase, Sarah McGowan, Erica Mondo, Edith L. Pfister, Eric Mick, Randall H. Friedline, Jason K. Kim, Ellen Sapp, Marian DiFiglia, and Neil Aronin

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A PH Domain with Dual Phospholipid Binding Sites Regulates the ARF GAP, ASAP1, Richard A. Kahn and David G. Lambright

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Research resource: Monitoring endoplasmic reticulum membrane integrity in beta-cells at the single-cell level, Kohsuke Kanekura, Jianhong Ou, Takashi Hara, Lihua (Julie) Zhu, and Fumihiko Urano

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Functional annotation of native enhancers with a Cas9-histone demethylase fusion, Nicola A. Kearns, Hannah Pham, Barbara Tabak, Ryan M. J. Genga, Noah J. Silverstein, Manuel Garber, and Rene Maehr

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Early antiretroviral therapy in children perinatally infected with HIV: a unique opportunity to implement immunotherapeutic approaches to prolong viral remission, Nigel Klein, Paolo Rossi, Katherine Luzuriaga, Savita Pahwa, Eleni Nastouli, Diane M. Gibb, Pablo Rojo, William Borkowsky, Stefania Bernardi, Paola Zangari, Vincent Calvez, Alexandra Compagnucci, Britta Wahren, Caroline Foster, and Maria Angeles Munoz-Fernandez

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Studying Cellular Signal Transduction with OMIC Technologies, Benjamin D. Landry, David C. Clarke, and Michael J. Lee (Journal of molecular biology)

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TRIM5 retroviral restriction activity correlates with the ability to induce innate immune signaling, Josefina Lascano, Pradeep Uchil, Walther Mothes, and Jeremy Luban

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Study of GABA in Healthy Volunteers: Pharmacokinetics and Pharmacodynamics, Junfeng Li, Zhaoyun Zhang, Xiaoxia Liu, Yi Wang, Fei Mao, Junjun Mao, Xiaolan Lu, Dongdong Jiang, Yun Wan, Jia-Ying Lv, Guoying Cao, Jing Zhang, Naiqing Zhao, Mark Atkinson, Dale L. Greiner, Gerald J. Prud'homme, Zheng Jiao, Yiming Li, and Qinghua Wang

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Efficient and Targeted Transduction of Nonhuman Primate Liver With Systemically Delivered Optimized AAV3B Vectors, Shaoyong Li, Li Zhong, Mengxin Li, Qin Su, Ran He, Qiushi Tang, Dale L. Greiner, Michael A. Brehm, Terence R. Flotte, Christian Mueller, and Guangping Gao

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A versatile reporter system for CRISPR-mediated chromosomal rearrangements, Yingxiang Li, Angela I. Park, Haiwei Mou, Cansu Colpan, Aizhan Bizhanova, Elliot Akama-Garren, Nik Joshi, Eric A. Hendrickson, David Feldser, Hao Yin, Daniel G. Anderson, Tyler Jacks, Zhiping Weng, and Wen Xue

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Global genetic analysis in mice unveils central role for cilia in congenital heart disease, You Li, Jovenal T. San Agustin, Gregory J. Pazour, and Cecilia W. Lo

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Transcription Factor Activity Mapping of a Tissue-Specific Gene Regulatory Network, Lesley T. MacNeil, Carles Pons, H. Efsun Arda, Gabrielle E. Giese, Chad L. Myers, and Albertha J. M. Walhout (Cell systems)

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Prostate Tumorigenesis Induced by PTEN Deletion Involves Estrogen Receptor beta Repression, Paul Mak, Jianrong Li, Sanjoy Samanta, Cheng Chang, D. Joseph Jerry, Roger J. Davis, Irwin Leav, and Arthur M. Mercurio

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JNK-interacting protein 1 mediates Alzheimer's-like pathological features in AICD-transgenic mice, Daniel R. Margevicius, Chinthasagar Bastian, Qingyuan Fan, Roger J. Davis, and Sanjay W. Pimplikar

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Ciliary proteins Bbs8 and Ift20 promote planar cell polarity in the cochlea, Helen L. May-Simera, Ronald S. Petralia, Mireille Montcouquiol, Ya-Xian Wang, Katherine B. Szarama, Yun Liu, Weichun Lin, Michael R. Deans, Gregory J. Pazour, and Matthew W. Kelley

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Understanding multifactorial influences on the continuum of maternal weight trajectories in pregnancy and early postpartum: study protocol, and participant baseline characteristics, Tiffany A. Moore Simas, Silvia Corvera, Mary M. Lee, Ningning Zhang, Katherine Leung, Barbara C. Olendzki, Bruce A. Barton, and Milagros C. Rosal

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Precision cancer mouse models through genome editing with CRISPR-Cas9, Haiwei Mou, Zachary Kennedy, Daniel G. Anderson, Hao Yin, and Wen Xue

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HIV-1 non-macrophage-tropic R5 envelope glycoproteins are not more tropic for entry into primary CD4+ T-cells than envelopes highly adapted for macrophages, Thomas A. Musich, Olivia O'Connell, Maria Paz Gonzalez-Perez, Cynthia A. Derdeyn, Paul J. Peters, and Paul R. Clapham

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Bunched and Madm Function Downstream of Tuberous Sclerosis Complex to Regulate the Growth of Intestinal Stem Cells in Drosophila, Yingchao Nie, Qi Li, Alla Amcheslavsky, Juan Carlos Duhart, Alexey Veraksa, Hugo Stocker, Laurel A. Raftery, and Y. Tony Ip

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Presynaptic c-Jun N-terminal Kinase 2 regulates NMDA receptor-dependent glutamate release, Robert Nistico, Fulvio Florenzano, Dalila Mango, Caterina Ferraina, Massimo Grilli, Silvia Di Prisco, Annalisa Nobili, Stefania Saccucci, Marcello D'Amelio, Michela Morbin, Mario Marchi, Nicola B. Mercuri, Roger J. Davis, Anna Pittaluga, and Marco Feligioni

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Effect of transmission intensity and age on subclass antibody responses to Plasmodium falciparum pre-erythrocytic and blood-stage antigens, Gregory S. Noland, Paul Jansen, John M. Vulule, Gregory S. Park, Bartholomew N. Ondigo, James W. Kazura, Ann M. Moormann, and Chandy C. John

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Guanabenz (Wytensin) selectively enhances uptake and efficacy of hydrophobically modified siRNAs, Maire F. Osborn, Julia F. Alterman, Mehran Nikan, Hong Cao, Marie C. Didiot, Matthew R. Hassler, Andrew H. Coles, and Anastasia Khvorova

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A major role of insulin in promoting obesity-associated adipose tissue inflammation, David J. Pedersen, Adilson L Guilherme, Laura V. Danai, Lauren Heyda, Anouch Matevossian, Jessica L. Cohen, Sarah M. Nicoloro, Juerg R. Straubhaar, Hye Lim Noh, Dae Young Jung, Jason K. Kim, and Michael P. Czech

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Adipose Tissue Therapeutics for Scar Rehabilitation after Thermal Injury, Dylan Perry, Jorge R. Lujan-Hernandez, Ava Chappell, So Yun Min, Raghu Appasani, Raziel Rojas-Rodriguez, Michael S. Chin, Silvia Corvera, and Janice F. Lalikos

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Hepatic acetyl CoA links adipose tissue inflammation to hepatic insulin resistance and type 2 diabetes, Rachel J. Perry, Joao-Paulo G. Camporez, Romy Kursawe, Paul M. Titchenell, Dongyan Zhang, Curtis J. Perry, Michael J. Jurczak, Abulizi Abudukadier, Myoung Souk Han, Xian-Man Zhang, Hai-Bin Ruan, Xiaoyong Yang, Sonia Caprio, Susan M. Kaech, Hei Sook Sul, Morris J. Birnbaum, Roger J. Davis, Gary W. Cline, Kitt Falk Petersen, and Gerald I. Shulman

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Infection of ectocervical tissue and universal targeting of T-cells mediated by primary non-macrophage-tropic and highly macrophage-tropic HIV-1 R5 envelopes, Paul J. Peters, Maria Paz Gonzalez-Perez, Thomas A. Musich, Tiffany A. Moore Simas, Rongheng Lin, Abraham N. Morse, Robin J. Shattock, Cynthia A. Derdeyn, and Paul R. Clapham

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Lv4 Is a Capsid-Specific Antiviral Activity in Human Blood Cells That Restricts Viruses of the SIVMAC/SIVSM/HIV-2 Lineage Prior to Integration, Massimo Pizzato, Sean Matthew McCauley, Martha R. Neagu, Thomas Pertel, Claudia Firrito, Serena Ziglio, Ann Dauphin, Madeleine Zufferey, Lionel Berthoux, and Jeremy Luban

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RNA Exosome & Chromatin: The Yin & Yang of Transcription: A Dissertation, Mayuri Rege

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Chromatin Dynamics and the RNA Exosome Function in Concert to Regulate Transcriptional Homeostasis, Mayuri Rege, Vidya Subramanian, Chenchen Zhu, Tsung-Han S. Hsieh, Assaf Weiner, Nir Friedman, Sandra Clauder-Munster, Lars M. Steinmetz, Oliver J. Rando, Laurie A. Boyer, and Craig L. Peterson

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Caenorhabditis elegans microRNAs of the let-7 family act in innate immune response circuits and confer robust developmental timing against pathogen stress, Zhiji Ren and Victor R. Ambros

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Human adipose tissue expansion in pregnancy is impaired in gestational diabetes mellitus, Raziel Rojas-Rodriguez, Tiffany A. Moore Simas, Lawrence M. Lifshitz, Karl D. Bellve, So-Yun Min, Jacqueline Pires, Katherine Leung, Crina Boeras, Aylin Sert, Jacqueline T. Draper, and Silvia Corvera

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HIV-1 Nef promotes infection by excluding SERINC5 from virion incorporation, Annachiara Rosa, Ajit Chande, Serena Ziglio, Veronica De Sanctis, Roberto Bertorelli, Shih Lin Goh, Sean M. McCauley, Anetta Nowosielska, Stylianos E. Antonarakis, Jeremy Luban, Federico Andrea Santoni, and Massimo Pizzato

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Endothelial protein kinase MAP4K4 promotes vascular inflammation and atherosclerosis, Rachel J. Roth Flach, Athanasia Skoura, Anouch Matevossian, Laura V. Danai, Wei Zheng, Christian Cortes, Samit K. Bhattacharya, Myriam Aouadi, G. Nana Hagan, Joseph Yawe, Pranitha Vangala, Lorena Garcia Menendez, Marcus P. Cooper, Timothy P. Fitzgibbons, Leonard Buckbinder, and Michael P. Czech

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Widespread macromolecular interaction perturbations in human genetic disorders, Nidhi Sahni, Song Yi, Mikko Taipale, Juan Fuxman Bass, Jasmin Coulombe-Huntington, Frederick P. Roth, Yu Xia, Albertha J. M. Walhout, Susan Lindquist, and Marc Vidal (Cell)

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Intraflagellar transport is essential for mammalian spermiogenesis but is absent in mature sperm, Jovenal T. San Agustin, Gregory J. Pazour, and George B. Witman (Molecular biology of the cell)

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Recombination elevates the effective evolutionary rate and facilitates the establishment of HIV-1 infection in infants after mother-to-child transmission, Keri B. Sanborn, Mohan Somasundaran, Katherine Ruiz De Luzuriaga, and Thomas Leitner

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Highly selective in vivo labeling of subcutaneous white adipocyte precursors with Prx1-Cre, Joan Sanchez-Gurmaches, Wen-Yu Hsiao, and David A. Guertin

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Bone marrow-derived c-jun N-terminal kinase-1 (JNK1) mediates liver regeneration, Frederik M. Schaefer, Jin Peng, Wei Hu, Oliver Drvarov, Yulia A. Nevzorova, Gang Zhao, Malika Al. Masaoudi, Roger J. Davis, Christian Trautwein, and Francisco Javier Cubero

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The genome and transcriptome of the zoonotic hookworm Ancylostoma ceylanicum identify infection-specific gene families, Erich M. Schwarz, Yan Hu, Igor Antoshechkin, Melanie M. Miller, Paul W. Sternberg, and Raffi V. Aroian

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Protection against Experimental Cryptococcosis following Vaccination with Glucan Particles Containing Cryptococcus Alkaline Extracts, Charles A. Specht, Chrono K. Lee, Haibin Huang, Donald J. Tipper, Zu T. Shen, Jennifer K. Lodge, John D. Leszyk, Gary R. Ostroff, and Stuart M. Levitz

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An efficient and sensitive method for preparing cDNA libraries from scarce biological samples, Catherine H. Sterling, Isana Veksler-Lublinsky, and Victor R. Ambros

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Animal Models for Alopecia Areata: What and Where, John P. Sundberg, Kevin McElwee, Michael A. Brehm, Lishan Su, and Lloyd E. King Jr

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Dynamical features of the Plasmodium falciparum ribosome during translation, Ming Sun, Wen Li, Karin Blomqvist, Sanchaita Das, Yaser Hashem, Jeffrey D. Dvorin, and Joachim Frank

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Activated Kupffer cells inhibit insulin sensitivity in obese mice, Michaela Tencerova, Jessica L. Cohen, Yuefei Shen, Lorena Garcia-Menendez, Olga T. Gupta, Michael P. Czech, Myriam Aouadi, Pranitha Vangala, Sarah M. Nicoloro, Joseph Yawe, David J. Pedersen, Karen A. Gallagher-Dorval, and Richard A. Perugini

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Size- and shape-dependent foreign body immune response to materials implanted in rodents and non-human primates, Omid Veiseh, Dale L. Greiner, and Daniel G. Anderson

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eIF2alpha Confers Cellular Tolerance to S. aureus alpha-Toxin, Gisela von Hoven, Claudia Neukirch, Martina Meyenburg, Sabine Fuser, Maria Bidna Petrivna, Amable J. Rivas, Alexey Ryazanov, Randal J. Kaufman, Raffi V. Aroian, and Matthias Husmann

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Adenovirus-Mediated Somatic Genome Editing of Pten by CRISPR/Cas9 in Mouse Liver in Spite of Cas9-Specific Immune Responses, Dan Wang, Haiwei Mou, Shaoyong Li, Yingxiang Li, Soren Hough, Karen Tran, Jia Li, Hao Yin, Daniel G. Anderson, Erik J. Sontheimer, Zhiping Weng, Guangping Gao, and Wen Xue

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Structural analyses of the chromatin remodelling enzymes INO80-C and SWR-C, Shinya Watanabe, Dongyan Tan, Mahadevan Lakshminarasimhan, Michael P. Washburn, Eun-Jin Erica. Hong, Thomas Walz, and Craig L. Peterson

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Understanding Metabolic Regulation at a Systems Level: Metabolite Sensing, Mathematical Predictions, and Model Organisms, Emma Watson, L. Safak Yilmaz, and Albertha J. M. Walhout (Annual review of genetics)

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Ack1 is a dopamine transporter endocytic brake that rescues a trafficking-dysregulated ADHD coding variant, Sijia Wu, Karl D. Bellve, Kevin E. Fogarty, and Haley Melikian

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The Ino80 complex prevents invasion of euchromatin into silent chromatin, Yong Xue, Christopher Van, Suman K. Pradhan, Trent Su, Jason Gehrke, Benjamin G. Kuryan, Tasuku Kitada, Ajay Vashisht, Nancy Tran, James Wohlschlegel, Craig L. Peterson, Siavash K. Kurdistani, and Michael F. Carey

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Lixisenatide accelerates restoration of normoglycemia and improves human beta-cell function and survival in diabetic immunodeficient NOD-scid IL-2rg(null) RIP-DTR mice engrafted with human islets, Chaoxing Yang, Matthias Loehn, Agata Jurczyk, Natalia Przewozniak, Linda Leehy, Pedro L. Herrera, Leonard D. Shultz, Dale L. Greiner, David Harlan, and Rita Bortell

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Pathological axonal death through a MAPK cascade that triggers a local energy deficit, Jing Yang, Zhuhao Wu, Nicolas Renier, David J. Simon, Kunihiro Uryu, David S. Park, Peter A. Greer, Cathy Tournier, Roger J. Davis, and Marc Tessier-Lavigne

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Intraflagellar transport 27 is essential for hedgehog signaling but dispensable for ciliogenesis during hair follicle morphogenesis, Ning Yang, Li Li, Thibaut Eguether, John P. Sundberg, Gregory J. Pazour, and Jiang Chen

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Intraflagellar transport 27 is essential for hedgehog signaling but dispensable for ciliogenesis during hair follicle morphogenesis, Ning Yang, Li Li, Thibaut Eguether, John P. Sundberg, Gregory J. Pazour, and Jiang Chen

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Regulation of Adipose Tissue Inflammation and Insulin Resistance by MAPK Phosphatase 5, Yongliang Zhang, Thang Nguyen, Peng Tang, Norman J. Kennedy, Huipeng Jiao, Mingliang Zhang, Joseph M. Reynolds, Anja Jaeschke, Natalia Martin-Orozco, Yeonseok Chung, Wei-min He, Chen Wang, Weiping Jia, Baoxue Ge, Roger J. Davis, Richard A. Flavell, and Chen Dong

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A multilaboratory comparison of calibration accuracy and the performance of external references in analytical ultracentrifugation, Huaying Zhao, Kimberly A. Crowley, Craig L. Peterson, Sarah G. Swygert, and Peter Schuck

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Caenorhabditis elegans ALG-1 antimorphic mutations uncover functions for Argonaute in microRNA guide strand selection and passenger strand disposal, Anna Y. Zinovyeva, Isana Veksler-Lublinsky, Ajay A. Vashisht, James A. Wohlschlegel, and Victor R. Ambros

Publications from 2014

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NPHP4 controls ciliary trafficking of membrane proteins and large soluble proteins at the transition zone, Junya Awata, Saeko Takada, Clive Standley, Karl-Ferdinand Lechtreck, Karl D. Bellve, Gregory J. Pazour, Kevin E. Fogarty, and George B. Witman (Journal of cell science)

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Transcriptional regulation of Caenorhabditis elegans FOXO/DAF-16 modulates lifespan, Ankita Bansal, Eun-Soo Kwon, Darryl Conte Jr., Haibo Liu, Michael J. Gilchrist, Lesley T. MacNeil, and Heidi A. Tissenbaum

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Gammaretroviral pol sequences act in cis to direct polysome loading and NXF1/NXT-dependent protein production by gag-encoded RNA, Hanni Bartels and Jeremy Luban

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TRIM37 is a new histone H2A ubiquitin ligase and breast cancer oncoprotein, Sanchita Bhatnagar, Claude Gazin, Lynn Chamberlain, Jianhong Ou, Xiaochun Zhu, Jogender S. Tushir, Ching-Man A. Virbasius, Ling Lin, Lihua Julie Zhu, Narendra Wajapeyee, and Michael R. Green

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Genetic and pharmacological reactivation of the mammalian inactive X chromosome, Sanchita Bhatnagar, Xiaochun Zhu, Jianhong Ou, Ling Lin, Lynn Chamberlain, Lihua Julie Zhu, Narendra Wajapeyee, and Michael R. Green

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Spectrum and mechanisms of inflammasome activation by chitosan, Chelsea L. Bueter, Chrono K. Lee, Jennifer P. Wang, Gary R. Ostroff, Charles A. Specht, and Stuart M. Levitz

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Unbiased chromatin accessibility profiling by RED-seq uncovers unique features of nucleosome variants in vivo, Poshen B. Chen, Lihua Julie Zhu, Sarah J. Hainer, Kurtis N. McCannell, and Thomas G. Fazzio

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Quantitative analysis of APP axonal transport in neurons: role of JIP1 in enhanced APP anterograde transport, Kyoko Chiba, Masahiko Araseki, Keisuke Nozawa, Keiko Furukori, Yoichi Araki, Takahide Matsushima, Tadashi Nakaya, Saori Hata, Yuhki Saito, Seiichi Uchida, Yasushi Okada, Angus C. Nairn, Roger J. Davis, Tohru Yamamoto, Masataka Kinjo, Hidenori Taru, and Toshiharu Suzuki

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PSF contacts exon 7 of SMN2 pre-mRNA to promote exon 7 inclusion, Sunghee Cho, Heegyum Moon, Tiing Jen Loh, Hyun Kyung Oh, Darren Reese Williams, D. Joshua Liao, Jianhua Zhou, Michael R. Green, Xuexiu Zheng, and Haihong Shen

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Adipose tissue angiogenesis: impact on obesity and type-2 diabetes, Silvia Corvera and Olga Gaelekman

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Distinct functions for IFT140 and IFT20 in opsin transport, Jacquelin A. Crouse, Vanda S. Lopes, Jovenal T. San Agustin, Brian T. Keady, David S. Williams, and Gregory J. Pazour

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Impaired JNK signaling cooperates with KrasG12D expression to accelerate pancreatic ductal adenocarcinoma, Clare C. Davies, Emma Harvey, Raymond F. T. McMahon, Katherine G. Finegan, Frances Connor, Roger J. Davis, David A. Tuveson, and Cathy Tournier

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Cyclophilin A promotes HIV-1 reverse transcription but its effect on transduction correlates best with its effect on nuclear entry of viral cDNA, Alberto De Iaco and Jeremy Luban

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Structural basis for PI(4)P-specific membrane recruitment of the Legionella pneumophila effector DrrA/SidM, Claudia M. Del Campo, Ashwini K. Mishra, Yu-Hsiu Wang, Craig R. Roy, Paul A. Janmey, and David G. Lambright

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Differentiation between temporary and real non-clearability of biotinylated IgG antibody by avidin in mice, Shuping Dou, John Virostko, Mary Rusckowski, Dale L. Greiner, Alvin C. Powers, and Guozheng Liu

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Comparison between two labeled agents in mice using a coinjection-ratio approach in contrast to a conventional group approach, Shuping Dou, Yuzhen Wang, Bruce A. Barton, Ling Chen, Mary Rusckowski, Leonard D. Shultz, Dale L. Greiner, and Guozheng Liu

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The BRAF oncoprotein functions through the transcriptional repressor MAFG to mediate the CpG Island Methylator phenotype, Minggang Fang, Jianhong Ou, Lloyd Hutchinson, and Michael R. Green

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Arf4 is required for Mammalian development but dispensable for ciliary assembly, John A. Follit, Jovenal T. San Agustin, Julie A. Jonassen, Tingting Huang, Jaime A. Rivera-Perez, Kimberly D. Tremblay, and Gregory J. Pazour

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Transcription factor binding to Caenorhabditis elegans first introns reveals lack of redundancy with gene promoters, Juan I. Fuxman Bass, Alex M. Tamburino, Akihiro Mori, Nathan Beittel, Matthew T. Weirauch, John S. Reece-Hoyes, and Albertha J. M. Walhout (Nucleic acids research)

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A single vertebrate DNA virus protein disarms invertebrate immunity to RNA virus infection, Don B. Gammon, Sophie Duraffour, Daniel K. Rozelle, Heidi Hehnly, Rita Sharma, Michael E. Sparks, Cara C. West, Ying Chen, James J. Moresco, Graciela Andrei, John H. Connor, Darryl Conte Jr., Dawn E. Gundersen-Rindal, William L. Marshall, John R. Yates, Neal S. Silverman, and Craig C. Mello

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Regulated splicing of the alpha6 integrin cytoplasmic domain determines the fate of breast cancer stem cells, Hira Lal Goel, Tatiana Gritsko, Bryan Pursell, Cheng Chang, Leonard D. Shultz, Dale L. Greiner, Jens Henrik Norum, Rune Toftgard, Leslie M. Shaw, and Arthur M. Mercurio

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An improved predictive recognition model for Cys(2)-His(2) zinc finger proteins, Ankit Gupta, Ryan G. Christensen, Heather A. Bell, Mathew Goodwin, Ronak Y. Patel, Manishi Pandey, Metewo Selase Enuameh, Amy L. Rayla, Cong Zhu, Stacey Thibodeau-Beganny, Michael H. Brodsky, J. Keith Joung, Scot A. Wolfe, and Gary D. Stormo

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Synergistic tumor suppression by combined inhibition of telomerase and CDKN1A, Romi Gupta, Yuying Dong, Peter D. Solomon, Hiromi I. Wettersten, Christopher J. Cheng, JIn-Na Min, Jeremy Henson, Shaillay Kumar Dogra, Sung H. Hwang, Bruce D. Hammock, Lihua Julie Zhu, Roger R. Reddel, W. Mark Saltzman, Robert H. Weiss, Sandy Chang, Michael R. Green, and Narendra Wajapeyee

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Rab11 endosomes contribute to mitotic spindle organization and orientation, Heidi Hehnly and Stephen J. Doxsey

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The machinery at endoplasmic reticulum-plasma membrane contact sites contributes to spatial regulation of multiple Legionella effector proteins, Andree Hubber, Kohei Arasaki, Fubito Nakatsu, Camille Hardiman, David G. Lambright, Pietro De Camilli, Hiroki Nagai, and Craig R. Roy

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Rictor/mTORC2 Loss in the Myf5 Lineage Reprograms Brown Fat Metabolism and Protects Mice against Obesity and Metabolic Disease, Chien-Min Hung, Camila Martinez Calejman, Joan Sanchez-Gurmaches, Huawei Li, Clary B. Clish, Simone Hettmer, Amy J. Wagers, and David A. Guertin