The Program in Molecular Medicine at the University of Massachusetts Medical School was established in a new research building in 1989. Faculty include both clinical investigators and basic scientists, many of whom focus their research on human disease processes. The laboratory groups and core facilities that compose Molecular Medicine represent many disciplines in the bio-medical sciences: biochemistry and molecular biology, cell biology, medicine, immunology, molecular genetics and microbiology, pediatrics, pharmacology, physiology, genomics, bioinformatics and proteomics. This diverse scientific environment makes the Program an exceptional training ground for graduate students and postdoctoral fellows, who in turn contribute much to its vitality and excitement. This collection showcases publications and presentations written by faculty and researchers of the Program in Molecular Medicine.

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Publications from 2013

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An unusual two-step control of CPEB destruction by Pin1, Morris Nechama, Chien-Ling Lin, and Joel D. Richter

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Survival response to increased ceramide involves metabolic adaptation through novel regulators of glycolysis and lipolysis, Niraj K. Nirala, Motiur Rahman, Stanley M. Walls, Alka Singh, Lihua Julie Zhu, Takeshi Bamba, Eiichiro Fukusaki, Sargur M. Srideshikan, Greg L. Harris, Y. Tony Ip, Rolf Bodmer, and Usha Acharya

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Efficiency of bridging-sheet recruitment explains HIV-1 R5 envelope glycoprotein sensitivity to soluble CD4 and macrophage tropism, Olivia J. O'Connell, Alexander Repik, Jacqueline D. Reeves, Maria Paz Gonzalez-Perez, Briana Quitadamo, Elizabeth D. Anton, Maria J. Duenas-Decamp, Paul J. Peters, Rongheng Lin, Susan Zolla-Pazner, Davide Corti, Aaron Wallace, Shixia Wang, Xiang-Peng Kong, Shan Lu, and Paul R. Clapham

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Transposition-driven genomic heterogeneity in the Drosophila brain, Paola N. Perrat, Shamik DasGupta, Jie Wang, William E. Theurkauf, Zhiping Weng, Michael Rosbash, and Scott Waddell

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Absence of detectable HIV-1 viremia after treatment cessation in an infant, Deborah Persaud, Hannah Gay, Carrie Ziemniak, Ya Hui Chen, Michael Piatak Jr., Tae-Wook Chun, Matthew Strain, Douglas Richman, and Katherine Ruiz De Luzuriaga

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Human immunodeficiency viruses: propagation, quantification, and storage, Paul J. Peters, Kathryn H. Richards, and Paul R. Clapham

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Complex expression dynamics and robustness in C. elegans insulin networks, Ashlyn D. Ritter, Yuan Shen, Juan Fuxman Bass, Sankarganesh Jeyaraj, Bart Deplancke, Arnab Mukhopadjay, Jian Xu, Monica Driscoll, Heidi A. Tissenbaum, and Albertha J. M. Walhout

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beta3-Adrenergic receptor stimulation induces E-selectin-mediated adipose tissue inflammation, Rachel J. Roth Flach, Anouch Matevossian, Thomas E. Akie, Kimberly A. Negrin, Marina T. Paul, and Michael P. Czech

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Endocytic transport and cytokinesis: from regulation of the cytoskeleton to midbody inheritance, John Schiel, Carly Childs, and Rytis Prekeris

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UPF1 is Crucial for the Infectivity of Human Immunodeficiency Virus type 1 Progeny Virions, Anna Kristina Serquina, Suman R. Das, Elena Popova, Ogooluwa A. Ojelabi, Christian K. Roy, and Heinrich G. Gottlinger

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The C. elegans CSR-1 argonaute pathway counteracts epigenetic silencing to promote germline gene expression, Meetu Seth, Masaki Shirayama, Weifeng Gu, Takao Ishidate, Darryl Conte Jr., and Craig C. Mello

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Accurate identification of polyadenylation sites from 3' end deep sequencing using a naive Bayes classifier, Sarah E. Sheppard, Nathan D. Lawson, and Lihua Julie Zhu

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Recurrent and recent selective sweeps in the piRNA pathway, Alfred Simkin, Alex Wong, Yu-Ping Poh, William E. Theurkauf, and Jeffrey D. Jensen

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Jumping over the fence: RNA nuclear export revisited, Caterina Strambio-De-Castilla

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Dendritic GluN2A Synthesis Mediates Activity-Induced NMDA Receptor Insertion, Sharon A. Swanger, Yuncan A. He, Joel D. Richter, and Gary J. Bassell

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A compendium of Caenorhabditis elegans RNA binding proteins predicts extensive regulation at multiple levels, Alex M. Tamburino, Sean P. Ryder, and Albertha J. M. Walhout

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Genetic and acute CPEB1 depletion ameliorate fragile X pathophysiology, Tsuyoshi Udagawa, Natalie G. Farny, Mira Jakovcevski, Hanoch Kaphzan, Juan Marcos Alarcon, Shobha Anilkumar, Maria Ivshina, Jessica A. Hurt, Kentaro Nagaoka, Vijayalaxmi C. Nalavadi, Lori J. Lorenz, Gary J. Bassell, Schahram Akbarian, Sumantra Chattarji, Eric Klann, and Joel D. Richter

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Diet-induced obesity mediated by the JNK/DIO2 signal transduction pathway, Santiago Vernia, Julie Cavanagh-Kyros, Tamera Barrett, Dae Young Jung, Jason K. Kim, and Roger J. Davis

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C. elegans sirtuins, Mohan Viswanathan and Heidi A. Tissenbaum

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Identification of Map4k4 as a novel suppressor of skeletal muscle differentiation, Mengxi Wang, Shinya U. Amano, Rachel J. Roth Flach, Anil Chawla, Myriam Aouadi, and Michael P. Czech

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Circulating Cell and Plasma microRNA Profiles Differ between Non-ST-Segment and ST-Segment-Elevation Myocardial Infarction, Jeanine Ward, Nada Esa, Rahul Pidikiti, Jane E. Freedman, John F. Keaney, Kahraman Tanriverdi, Olga Vitseva, Victor R. Ambros, Rosalind Lee, and David D. McManus

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A histone acetylation switch regulates H2A.Z deposition by the SWR-C remodeling enzyme, Shinya Watanabe, Marta Radman-Livaja, Oliver J. Rando, and Craig L. Peterson

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Integration of Metabolic and Gene Regulatory Networks Modulates the C. elegans Dietary Response, Emma Watson, Lesley T. MacNeil, H. Efsun Arda, Lihua Julie Zhu, and Albertha J. M. Walhout

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Evidence for biphasic uncoating during HIV-1 infection from a novel imaging assay, Hongzhan Xu, Tamera Franks, Gregory Gibson, Kelly Huber, Nadia Rahm, Caterina Strambio De Castilla, Jeremy Luban, Christopher Aiken, Simon Watkins, Nicolas Sluis-Cremer, and Zandrea Ambrose

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Salicylate prevents virus-induced type 1 diabetes in the BBDR rat, Chaoxing Yang, Agata Jurczyk, Philip J. diIorio, Elaine Norowski, Michael A. Brehm, Christian W. Grant, Dennis L. Guberski, Dale L. Greiner, and Rita Bortell

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GABP transcription factor is required for development of chronic myelogenous leukemia via its control of PRKD2, Zhongfa Yang, Haojian Zhang, Leyuan Ma, Cong Peng, Yaoyu Chen, Junling Wang, Michael R. Green, Shaoguang Li, and Alan G. Rosmarin

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Integrative Analysis of ChIP-Chip and ChIP-Seq Dataset, Lihua Julie Zhu

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Developmental decline in neuronal regeneration by the progressive change of two intrinsic timers, Yan Zou, Hui Chiu, Anna Y. Zinovyeva, Victor R. Ambros, Chiou-Fen Chuang, and Chieh Chang

Publications from 2012

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Cytoplasmic polyadenylation element binding protein deficiency stimulates PTEN and Stat3 mRNA translation and induces hepatic insulin resistance, Ilya M. Alexandrov, Maria Ivshina, Dae Young Jung, Randall H. Friedline, Hwi Jin Ko, Mei Xu, Bryan O'Sullivan-Murphy, Rita Bortell, Yen-Tsung Huang, Fumihiko Urano, Jason K. Kim, and Joel D. Richter

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KRAS(G12D)- and BRAF(V600E)-induced transformation of murine pancreatic epithelial cells requires MEK/ERK-stimulated IGF1R signaling, Victoria A. Appleman, Leanne G. Ahronian, JiuFeng Cai, David S. Klimstra, and Brian C. Lewis

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Releasing the break on X chromosome inactivation: Rnf12/RLIM targets REX1 for degradation, Ingolf Bach

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Coordination of cell growth and division by the ubiquitin-proteasome system, Jennifer A. Benanti

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Engraftment of human HSCs in nonirradiated newborn NOD-scid IL2rgamma null mice is enhanced by transgenic expression of membrane-bound human SCF, Michael A. Brehm, Racki J. Waldemar, Jean H. Leif, Lisa M. Burzenski, Vishnu Hosur, Amber Wetmore, Bruce Gott, Mary Herlihy, Ronald A. Ignotz, Raymond M. Dunn, Leonard D. Shultz, and Dale L. Greiner

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Role of JNK in mammary gland development and breast cancer, Cristina Arrigo Cellurale, Nomeda Girnius, Feng Jiang, Julie Cavanagh-Kyros, Shaolei Lu, David S. Garlick, Arthur M. Mercurio, and Roger J. Davis

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Recognition models to predict DNA-binding specificities of homeodomain proteins, Ryan G. Christensen, Metewo Selase Enuameh, Marcus Blaine Noyes, Michael H. Brodsky, Scot A. Wolfe, and Gary D. Stormo

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Exploring the DNA-recognition potential of homeodomains, Stephanie W. Chu, Marcus Blaine Noyes, Ryan G. Christensen, Brian G. Pierce, Lihua Julie Zhu, Zhiping Weng, Gary D. Stormo, and Scot A. Wolfe

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Maternal immune activation alters behavior in adult offspring, with subtle changes in the cortical transcriptome and epigenome, Caroline M. Connor, Aslihan Dincer, Juerg R. Straubhaar, Janina R. Galler, Isaac B. Houston, and Schahram Akbarian

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The role of retrograde intraflagellar transport in flagellar assembly, maintenance, and function, Benjamin D. Engel, Hiroaki Ishikawa, Kimberly A. Wemmer, Stefan Geimer, Ken-ichi Wakabayashi, Masafumi Hirono, Branch Craige, Gregory J. Pazour, George B. Witman, Ritsu Kamiya, and Wallace F. Marshall

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Novel paths to antifungal therapeutics, Ahmed Fazly, Charu Jain, Reeta Prusty Rao, and Paul D. Kaufman

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NURDs are required for diversity, Thomas G. Fazzio and Oliver J. Rando

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A regulatory cascade of three transcription factors in a single specific neuron, DVC, in Caenorhabditis elegans, Huiyun Feng, John S. Reece-Hoyes, Albertha J. M. Walhout, and Ian A. Hope

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VEGF/Neuropilin-2 Regulation of Bmi-1 and Consequent Repression of IGF-IR Define a Novel Mechanism of Aggressive Prostate Cancer, Hira Lal Goel, Cheng Chang, Bryan M. Pursell, Irwin Leav, Stephen Lyle, Hualin Simon Xi, Chung-Cheng Hsieh, Helty Adisetiyo, Pradip Roy-Burman, Ilsa M. Coleman, Peter S. Nelson, Robert L. Vessella, Roger J. Davis, Stephen R. Plymate, and Arthur M. Mercurio

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The Iddm14 gene is Tcrbv-13S1A1: Prevention of Autoimmune Diabetes in the Rat with an Allele-Specific Depleting Antibody That Recognizes the Vβ13a T Cell Receptor Beta Chain, Michael Habib, Ryan Eberwine, Zhijun Liu, Thomas Herrmann, Dale Greiner, Laura Cort, Elizabeth P. Blankenhorn, and John P. Mordes

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What causes the insulin resistance underlying obesity?, Olga T. Hardy, Michael P. Czech, and Silvia Corvera

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Paternal RLIM/Rnf12 Is a Survival Factor for Milk-Producing Alveolar Cells, Baowei Jiao, Hong Ma, Maxim N. Shokhirev, Alexander Drung, Qin Yang, JongDae Shin, Shaolei Lu, Meg Byron, Sundeep Kalantry, Arthur M. Mercurio, Jeanne B. Lawrence, Alexander Hoffmann, and Ingolf Bach

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Disruption of IFT Complex A Causes Cystic Kidneys without Mitotic Spindle Misorientation, Julie A. Jonassen, Jovenal T. San Agustin, Stephen P. Baker, and Gregory J. Pazour

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Dauer larva quiescence alters the circuitry of microRNA pathways regulating cell fate progression in C. elegans, Xantha Karp and Victor R. Ambros

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First-in-class small molecule inhibitors of the single-strand DNA cytosine deaminase APOBEC3G, Ming Li, Shivender Shandilya, Michael A. Carpenter, Anurag Rathore, William L. Brown, Angela L. Perkins, Daniel A. Harki, Jonathan Solberg, Derek J. Hook, Krishan K. Pandey, Michael A. Parniak, Jeffrey R. Johnson, Nevan J. Krogan, Mohan Somasundaran, Akbar Ali, Celia A. Schiffer, and Reuben S. Harris

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Analysis of Gal4-directed transcription activation using Tra1 mutants selectively defective for interaction with Gal4, Ling Lin, Lynn Chamberlain, Lihua Julie Zhu, and Michael R. Green

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Characterization of Enhancer Function from Genome-Wide Analyses, Glenn A. Maston, Stephen G. Landt, Michael Snyder, and Michael R. Green

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Non-canonical TAF complexes regulate active promoters in human embryonic stem cells, Glenn A. Maston, Lihua Julie Zhu, Lynn Chamberlain, Ling Lin, Minggang Fang, and Michael R. Green

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Circulating microRNAs are associated with Paroxysmal or Persistent Atrial Fibrillation, David D. McManus, Jeanine Ward, Amir Y. Shaikh, Khushleen Jaggi, Victor R. Ambros, Jane Freedman, and John F. Keaney Jr.

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Rabenosyn-5 Defines the Fate of the Transferrin Receptor Following Clathrin-mediated Endocytosis, Deanna M. Navaroli, Karl D. Bellve, Clive Standley, Lawrence M. Lifshitz, James Cardia, David Lambright, Deborah Leonard, Kevin E. Fogarty, and Silvia Corvera

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Translational control of mitochondrial energy production mediates neuron morphogenesis, Aparna Oruganty-Das, Teclise Ng, Tsuyoshi Udagawa, Eyleen L. K. Goh, and Joel D. Richter

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ER stress as a trigger for beta-cell dysfunction and autoimmunity in type 1 diabetes, Bryan M. O'Sullivan-Murphy and Fumihiko Urano

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The histone demethylase jhdm1a regulates hepatic gluconeogenesis, Dongning Pan, Chunxiao Mao, Tie Zou, Annie Y. Yao, Marcus P. Cooper, Victor L. Boyartchuk, and Yong-Xu Wang

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Integration of beta-Catenin, Sirtuin, and FOXO Signaling Protects from Mutant Huntingtin Toxicity, J. Alex Parker, Rafael P. Vazquez-Manrique, Cendrine Tourette, Francesca Farina, Nicolas Offner, Arnab Mukhopadhyay, Anne-Marie Orfila, Aurelie Darbois, Sophie Menet, Heidi A. Tissenbaum, and Christian Neri

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Dynamics of the resting CD4(+) T-cell latent HIV reservoir in infants initiating HAART less than 6 months of age, Deborah Persaud, Paul E. Palumbo, Carrie Ziemniak, Michael D. Hughes, Carmelita G. Alvero, Katherine Luzuriaga, Ram Yogev, Edmund V. Capparelli, and Ellen Gould Chadwick

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The activity of Gli transcription factors is essential for Kras-induced pancreatic tumorigenesis, Mihir Rajurkar, Wilfredo E. De Jesus-Monge, David R. Driscoll, Victoria A. Appleman, He Huang, Jennifer L. Cotton, David S. Klimstra, Lihua Julie Zhu, Karl Simin, Lan Xu, Andrew P. McMahon, Brian C. Lewis, and Junhao Mao

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Gene-centered yeast one-hybrid assays, John S. Reece-Hoyes and Albertha J. M. Walhout

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PTEN Loss in the Myf5 Lineage Redistributes Body Fat and Reveals Subsets of White Adipocytes that Arise from Myf5 Precursors, Joan Sanchez-Gurmaches, Chien-Min Hung, Cynthia A. Sparks, Yuefeng Tang, Huawei Li, and David A. Guertin

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Transcriptional consequences of aneuploidy, Jason M. Sheltzer, Eduardo M. Torres, Maitreya J. Dunham, and Angelika Amon

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Regulation of CHMP4/ESCRT-III function in human immunodeficiency virus type 1 budding by CC2D1A, Yoshiko Usami, Sergei Popov, Eric R. Weiss, Christie Vriesema-Magnuson, Arianna Calistri, and Heinrich G. Gottlinger

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Pilot study on the immunogenicity of paired Env immunogens from mother-to-child transmitted HIV-1 isolates, Shixia Wang, Michael G. Kishko, Shengqin Wan, Yan Wang, Frank E. Brewster, Glenda E. Gray, Avye Violari, John L. Sullivan, Mohan Somasundaran, Katherine Luzuriaga, and Shan Lu

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Transcription factor ATF5 is required for terminal differentiation and survival of olfactory sensory neurons, Shu-Zong Wang, Jianhong Ou, Lihua Julie Zhu, and Michael R. Green

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Long-term, efficient inhibition of microRNA function in mice using rAAV vectors, Jun Xie, Stefan L. Ameres, Randall H. Friedline, Jui-Hung Hung, Yu Zhang, Qing Xie, Li Zhong, Qin Su, Ran He, Mengxin Li, Huapeng Li, Xin Mu, Hongwei Zhang, Jennifer A. Broderick, Jason K. Kim, Zhiping Weng, Terence R. Flotte, Phillip D. Zamore, and Guangping Gao

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A Synthetic Interaction Screen Identifies Factors Selectively Required for Proliferation and TERT Transcription in p53-Deficient Human Cancer Cells, Li Xie, Claude Gazin, Sung Mi Park, Lihua Julie Zhu, Marie-Anne Debily, Ellen L. W. Kittler, Maria L. Zapp, David S. Lapointe, Stephane Gobeil, Ching-Man A. Virbasius, and Michael R. Green

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UAP56 couples piRNA clusters to the perinuclear transposon silencing machinery, Fan Zhang, Jie Wang, Jia Xu, Zhao Zhang, Birgit S. Koppetsch, Nadine Schultz, Thom Vreven, Carine Meignin, Ilan Davis, Phillip D. Zamore, Zhiping Weng, and William E. Theurkauf

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The Blk pathway functions as a tumor suppressor in chronic myeloid leukemia stem cells, Haojian Zhang, Cong Peng, Yiguo Hu, Huawei Li, Zhi Sheng, Yaoyu Chen, Con Sullivan, Jan Cerny, Lloyd Hutchinson, Anne Higgins, Patricia M. Miron, Xueqing Zhang, Michael A. Brehm, Dongguang Li, Michael R. Green, and Shaoguang Li

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Strand-specific libraries for high throughput RNA sequencing (RNA-Seq) prepared without poly(A) selection, Zhao Zhang, William E. Theurkauf, Zhiping Weng, and Phillip D. Zamore

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Chondrolectin mediates growth cone interactions of motor axons with an intermediate target, Zhen Zhong, Jochen Ohnmacht, Michell M. Reimer, Ingolf Bach, Thomas C. Becker, and Catherina G. Becker

Publications from 2011

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Genomics in 2011: challenges and opportunities, David J. Adams, Bonnie Berger, Olivier Harismendy, Curtis Huttenhower, X. Shirley Liu, Chad L. Myers, Alicia Oshlack, John L. Rinn, and Albertha J. M. Walhout

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MicroRNAs and developmental timing, Victor R. Ambros

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A stele-enriched gene regulatory network in the Arabidopsis root, Siobhan M. Brady, Lifang Zhang, Molly Megraw, Natalia Julia Martinez, Eric Jiang, Charles S. Yi, Weilin Liu, Anna Zeng, Mallorie Taylor-Teeples, Dahae Kim, Sebastian Ahnert, Uwe Ohler, Doreen Ware, Albertha J. M. Walhout, and Philip N. Benfey

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The cilia protein IFT88 is required for spindle orientation in mitosis, Benedicte Delaval, Alison Bright, Nathan D. Lawson, and Stephen J. Doxsey

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Centrin depletion causes cyst formation and other ciliopathy-related phenotypes in zebrafish, Benedicte Delaval, Laurence D. Covassin, Nathan D. Lawson, and Stephen J. Doxsey

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Using a structural and logics systems approach to infer bHLH-DNA binding specificity determinants, Federico De Masi, Christian A. Grove, Anastasia Vedenko, Andreu Alibés, Stephen S. Gisselbrecht, Luis Serrano, Martha L. Bulyk, and Albertha J. M. Walhout

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Endoplasmic reticulum stress and pancreatic beta-cell death, Sonya G. Fonseca, Jesper Gromada, and Fumihiko Urano

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Enhanced Y1H assays for Arabidopsis, Allison Gaudinier, Lifang Zhang, John S. Reece-Hoyes, Mallorie Taylor-Teeples, Li Pu, Zhijie Liu, Ghislain Breton, Jose L. Pruneda-Paz, Dahae Kim, Steve A. Kay, Albertha J. M. Walhout, Doreen Ware, and Siobhan M. Brady

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Body mass index-independent inflammation in omental adipose tissue associated with insulin resistance in morbid obesity, Olga T. Hardy, Richard A. Perugini, Sarah M. Nicoloro, Karen A. Gallagher-Dorval, Vishwajeet Puri, Juerg R. Straubhaar, and Michael P. Czech

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A unified taxonomy for ciliary dyneins, Erik F. Y. Hom, George B. Witman, Elizabeth H. Harris, Susan K. Dutcher, Ritsu Kamiya, David R. Mitchell, Gregory J. Pazour, Mary E. Porter, Winfield S. Sale, Maureen Wirschell, Toshiki Yagi, and Stephen M. King

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The COPI vesicle complex binds and moves with survival motor neuron within axons, Cyril P. Jayakumar, Matthew C. Evans, Venugopal Thayanithy, Naoko Taniguchi-Ishigaki, Ingolf Bach, Adrianne L. Kolpak, Gary J. Bassell, Rossoll Wilfried, Christian L. Lorson, Zheng-Zheng Bao, and Elliot J. Androphy

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The developmental timing regulator HBL-1 modulates the dauer formation decision in Caenorhabditis elegans, Xantha Karp and Victor R. Ambros

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Effect of life history on microRNA expression during C. elegans development, Xantha Karp, Molly Hammell, Maria C. Ow, and Victor R. Ambros

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Genome surveyor 2.0: cis-regulatory analysis in Drosophila, Majid Kazemian, Michael H. Brodsky, and Saurabh Sinha

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Adaptation to P element transposon invasion in Drosophila melanogaster, Jaspreet S. Khurana, Jie Wang, Jia Xu, Birgit S. Koppetsch, Travis Thomson, Anetta Nowosielska, Chengjian Li, Phillip D. Zamore, Zhiping Weng, and William E. Theurkauf

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Genotypic and functional properties of early infant HIV-1 envelopes, Michael G. Kishko, Mohan Somasundaran, Frank E. Brewster, John L. Sullivan, Paul R. Clapham, and Katherine Luzuriaga

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Midbody accumulation through evasion of autophagy contributes to cellular reprogramming and tumorigenicity, Tse-Chun Kuo, Chun-Ting Chen, Desiree Baron, Tamer T. Onder, Sabine Loewer, Sandra Almeida, Cara M. Weismann, Ping Xu, JeanMarie Houghton, Fen-Biao Gao, George Q. Daley, and Stephen J. Doxsey

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Human islet cell MORF/cMORF pretargeting in a xenogeneic murine transplant model, Guozheng Liu, Shuping Dou, Dengfeng Cheng, Jean H. Leif, Mary Rusckowski, Philip R. Streeter, Leonard D. Shultz, Donald J. Hnatowich, and Dale L. Greiner

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Gene regulatory networks and the role of robustness and stochasticity in the control of gene expression, Lesley T. MacNeil and Albertha J. M. Walhout

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Circulating MicroRNAs in cardiovascular disease, David D. McManus and Victor R. Ambros

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Imaging the pancreatic vasculature in diabetes models, Zdravka Medarova, Dale L. Greiner, Marytheresa Ifediba, Guangping Dai, Elijah Bolotin, Gerardo Castillo, Alexei A. Bogdanov Jr., Mohanraja Kumar, and Anna Moore

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Dicer is required for the formation of white but not brown adipose tissue, Rajini R. Mudhasani, Vishwajeet Puri, Kathleen Hoover, Michael P. Czech, Anthony N. Imbalzano, and Stephen N. Jones

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A conserved determinant in the V1 loop of HIV-1 modulates the V3 loop to prime low CD4 use and macrophage infection, Thomas A. Musich, Paul J. Peters, Maria J. Duenas-Decamp, Maria Paz Gonzalez-Perez, James E. Robinson, Susan Zolla-Pazner, Jonathan K. Ball, Katherine Luzuriaga, and Paul R. Clapham

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PDP-1 Links the TGF-β and IIS Pathways to Regulate Longevity, Development, and Metabolism, Sri Devi Narasimhan, Kelvin Yen, Ankita Bansal, Eun-Soo Kwon, Srivatsan Padmanabhan, and Heidi A. Tissenbaum

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The Plasma Membrane-Associated GTPase Rin Interacts with the Dopamine Transporter and Is Required for Protein Kinase C-Regulated Dopamine Transporter Trafficking, Deanna M. Navaroli, Zachary H. Stevens, Zeljko Uzelac, Luke Gabriel, Michael J. King, Lawrence M. Lifshitz, Harald H. Sitte, and Haley E. Melikian

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Effect of therapeutic HIV recombinant poxvirus vaccines on the size of the resting CD4+ T-cell latent HIV reservoir, Deborah Persaud, Katherine Luzuriaga, Carrie Ziemniak, Petronella Muresan, Thomas Greenough, Terry Fenton, Amanda Blackford, Kimberly Ferguson, Natalie Neu, and Coleen K. Cunningham

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Yeast one-hybrid assays for gene-centered human gene regulatory network mapping, John S. Reece-Hoyes, A. Rasim Barutcu, Rachel Patton McCord, Jun Seop Jeong, Lizhi Jiang, Andrew Macwilliams, Xinping Yang, Kourosh Salehi-Ashtiani, David E. Hill, Seth Blackshaw, Heng Zhu, Job Dekker, and Albertha J. M. Walhout

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Enhanced yeast one-hybrid assays for high-throughput gene-centered regulatory network mapping, John S. Reece-Hoyes, Alos Diallo, Bryan R. Lajoie, Amanda Kent, Shaleen Shrestha, Sreenath Kadreppa, Colin Pesyna, Job Dekker, Chad L. Myers, and Albertha J. M. Walhout

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BCR-ABL suppresses autophagy through ATF5-mediated regulation of mTOR transcription, Zhi Sheng, Leyuan Ma, Jiaoyuan Sun, Lihua Julie Zhu, and Michael R. Green