The Program in Molecular Medicine at the University of Massachusetts Medical School was established in a new research building in 1989. Faculty include both clinical investigators and basic scientists, many of whom focus their research on human disease processes. The laboratory groups and core facilities that compose Molecular Medicine represent many disciplines in the bio-medical sciences: biochemistry and molecular biology, cell biology, medicine, immunology, molecular genetics and microbiology, pediatrics, pharmacology, physiology, genomics, bioinformatics and proteomics. This diverse scientific environment makes the Program an exceptional training ground for graduate students and postdoctoral fellows, who in turn contribute much to its vitality and excitement. This collection showcases publications and presentations written by faculty and researchers of the Program in Molecular Medicine.

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Publications from 2012

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A regulatory cascade of three transcription factors in a single specific neuron, DVC, in Caenorhabditis elegans, Huiyun Feng, John S. Reece-Hoyes, Albertha J. M. Walhout, and Ian A. Hope

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VEGF/Neuropilin-2 Regulation of Bmi-1 and Consequent Repression of IGF-IR Define a Novel Mechanism of Aggressive Prostate Cancer, Hira Lal Goel, Cheng Chang, Bryan M. Pursell, Irwin Leav, Stephen Lyle, Hualin Simon Xi, Chung-Cheng Hsieh, Helty Adisetiyo, Pradip Roy-Burman, Ilsa M. Coleman, Peter S. Nelson, Robert L. Vessella, Roger J. Davis, Stephen R. Plymate, and Arthur M. Mercurio

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The Iddm14 gene is Tcrbv-13S1A1: Prevention of Autoimmune Diabetes in the Rat with an Allele-Specific Depleting Antibody That Recognizes the Vβ13a T Cell Receptor Beta Chain, Michael Habib, Ryan Eberwine, Zhijun Liu, Thomas Herrmann, Dale Greiner, Laura Cort, Elizabeth P. Blankenhorn, and John P. Mordes

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What causes the insulin resistance underlying obesity?, Olga T. Hardy, Michael P. Czech, and Silvia Corvera

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Paternal RLIM/Rnf12 Is a Survival Factor for Milk-Producing Alveolar Cells, Baowei Jiao, Hong Ma, Maxim N. Shokhirev, Alexander Drung, Qin Yang, JongDae Shin, Shaolei Lu, Meg Byron, Sundeep Kalantry, Arthur M. Mercurio, Jeanne B. Lawrence, Alexander Hoffmann, and Ingolf Bach

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Disruption of IFT Complex A Causes Cystic Kidneys without Mitotic Spindle Misorientation, Julie A. Jonassen, Jovenal T. San Agustin, Stephen P. Baker, and Gregory J. Pazour

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First-in-class small molecule inhibitors of the single-strand DNA cytosine deaminase APOBEC3G, Ming Li, Shivender Shandilya, Michael A. Carpenter, Anurag Rathore, William L. Brown, Angela L. Perkins, Daniel A. Harki, Jonathan Solberg, Derek J. Hook, Krishan K. Pandey, Michael A. Parniak, Jeffrey R. Johnson, Nevan J. Krogan, Mohan Somasundaran, Akbar Ali, Celia A. Schiffer, and Reuben S. Harris

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Analysis of Gal4-directed transcription activation using Tra1 mutants selectively defective for interaction with Gal4, Ling Lin, Lynn Chamberlain, Lihua Julie Zhu, and Michael R. Green

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Characterization of Enhancer Function from Genome-Wide Analyses, Glenn A. Maston, Stephen G. Landt, Michael Snyder, and Michael R. Green

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Non-canonical TAF complexes regulate active promoters in human embryonic stem cells, Glenn A. Maston, Lihua Julie Zhu, Lynn Chamberlain, Ling Lin, Minggang Fang, and Michael R. Green

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Circulating microRNAs are associated with Paroxysmal or Persistent Atrial Fibrillation, David D. McManus, Jeanine Ward, Amir Y. Shaikh, Khushleen Jaggi, Victor R. Ambros, Jane Freedman, and John F. Keaney Jr.

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Rabenosyn-5 Defines the Fate of the Transferrin Receptor Following Clathrin-mediated Endocytosis, Deanna M. Navaroli, Karl D. Bellve, Clive Standley, Lawrence M. Lifshitz, James Cardia, David Lambright, Deborah Leonard, Kevin E. Fogarty, and Silvia Corvera

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Translational control of mitochondrial energy production mediates neuron morphogenesis, Aparna Oruganty-Das, Teclise Ng, Tsuyoshi Udagawa, Eyleen L. K. Goh, and Joel D. Richter

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ER stress as a trigger for beta-cell dysfunction and autoimmunity in type 1 diabetes, Bryan M. O'Sullivan-Murphy and Fumihiko Urano

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The histone demethylase jhdm1a regulates hepatic gluconeogenesis, Dongning Pan, Chunxiao Mao, Tie Zou, Annie Y. Yao, Marcus P. Cooper, Victor L. Boyartchuk, and Yong-Xu Wang

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Integration of beta-Catenin, Sirtuin, and FOXO Signaling Protects from Mutant Huntingtin Toxicity, J. Alex Parker, Rafael P. Vazquez-Manrique, Cendrine Tourette, Francesca Farina, Nicolas Offner, Arnab Mukhopadhyay, Anne-Marie Orfila, Aurelie Darbois, Sophie Menet, Heidi A. Tissenbaum, and Christian Neri

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Dynamics of the resting CD4(+) T-cell latent HIV reservoir in infants initiating HAART less than 6 months of age, Deborah Persaud, Paul E. Palumbo, Carrie Ziemniak, Michael D. Hughes, Carmelita G. Alvero, Katherine Luzuriaga, Ram Yogev, Edmund V. Capparelli, and Ellen Gould Chadwick

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The activity of Gli transcription factors is essential for Kras-induced pancreatic tumorigenesis, Mihir Rajurkar, Wilfredo E. De Jesus-Monge, David R. Driscoll, Victoria A. Appleman, He Huang, Jennifer L. Cotton, David S. Klimstra, Lihua Julie Zhu, Karl Simin, Lan Xu, Andrew P. McMahon, Brian C. Lewis, and Junhao Mao

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Gene-centered yeast one-hybrid assays, John S. Reece-Hoyes and Albertha J. M. Walhout

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PTEN Loss in the Myf5 Lineage Redistributes Body Fat and Reveals Subsets of White Adipocytes that Arise from Myf5 Precursors, Joan Sanchez-Gurmaches, Chien-Min Hung, Cynthia A. Sparks, Yuefeng Tang, Huawei Li, and David A. Guertin

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Transcriptional consequences of aneuploidy, Jason M. Sheltzer, Eduardo M. Torres, Maitreya J. Dunham, and Angelika Amon

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Regulation of CHMP4/ESCRT-III function in human immunodeficiency virus type 1 budding by CC2D1A, Yoshiko Usami, Sergei Popov, Eric R. Weiss, Christie Vriesema-Magnuson, Arianna Calistri, and Heinrich G. Gottlinger

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Pilot study on the immunogenicity of paired Env immunogens from mother-to-child transmitted HIV-1 isolates, Shixia Wang, Michael G. Kishko, Shengqin Wan, Yan Wang, Frank E. Brewster, Glenda E. Gray, Avye Violari, John L. Sullivan, Mohan Somasundaran, Katherine Luzuriaga, and Shan Lu

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Transcription factor ATF5 is required for terminal differentiation and survival of olfactory sensory neurons, Shu-Zong Wang, Jianhong Ou, Lihua Julie Zhu, and Michael R. Green

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Long-term, efficient inhibition of microRNA function in mice using rAAV vectors, Jun Xie, Stefan L. Ameres, Randall H. Friedline, Jui-Hung Hung, Yu Zhang, Qing Xie, Li Zhong, Qin Su, Ran He, Mengxin Li, Huapeng Li, Xin Mu, Hongwei Zhang, Jennifer A. Broderick, Jason K. Kim, Zhiping Weng, Terence R. Flotte, Phillip D. Zamore, and Guangping Gao

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A Synthetic Interaction Screen Identifies Factors Selectively Required for Proliferation and TERT Transcription in p53-Deficient Human Cancer Cells, Li Xie, Claude Gazin, Sung Mi Park, Lihua Julie Zhu, Marie-Anne Debily, Ellen L. W. Kittler, Maria L. Zapp, David S. Lapointe, Stephane Gobeil, Ching-Man A. Virbasius, and Michael R. Green

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UAP56 couples piRNA clusters to the perinuclear transposon silencing machinery, Fan Zhang, Jie Wang, Jia Xu, Zhao Zhang, Birgit S. Koppetsch, Nadine Schultz, Thom Vreven, Carine Meignin, Ilan Davis, Phillip D. Zamore, Zhiping Weng, and William E. Theurkauf

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The Blk pathway functions as a tumor suppressor in chronic myeloid leukemia stem cells, Haojian Zhang, Cong Peng, Yiguo Hu, Huawei Li, Zhi Sheng, Yaoyu Chen, Con Sullivan, Jan Cerny, Lloyd Hutchinson, Anne Higgins, Patricia M. Miron, Xueqing Zhang, Michael A. Brehm, Dongguang Li, Michael R. Green, and Shaoguang Li

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Strand-specific libraries for high throughput RNA sequencing (RNA-Seq) prepared without poly(A) selection, Zhao Zhang, William E. Theurkauf, Zhiping Weng, and Phillip D. Zamore

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Chondrolectin mediates growth cone interactions of motor axons with an intermediate target, Zhen Zhong, Jochen Ohnmacht, Michell M. Reimer, Ingolf Bach, Thomas C. Becker, and Catherina G. Becker

Publications from 2011

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Genomics in 2011: challenges and opportunities, David J. Adams, Bonnie Berger, Olivier Harismendy, Curtis Huttenhower, X. Shirley Liu, Chad L. Myers, Alicia Oshlack, John L. Rinn, and Albertha J. M. Walhout

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A stele-enriched gene regulatory network in the Arabidopsis root, Siobhan M. Brady, Lifang Zhang, Molly Megraw, Natalia Julia Martinez, Eric Jiang, Charles S. Yi, Weilin Liu, Anna Zeng, Mallorie Taylor-Teeples, Dahae Kim, Sebastian Ahnert, Uwe Ohler, Doreen Ware, Albertha J. M. Walhout, and Philip N. Benfey

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The cilia protein IFT88 is required for spindle orientation in mitosis, Benedicte Delaval, Alison Bright, Nathan D. Lawson, and Stephen J. Doxsey

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Centrin depletion causes cyst formation and other ciliopathy-related phenotypes in zebrafish, Benedicte Delaval, Laurence D. Covassin, Nathan D. Lawson, and Stephen J. Doxsey

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Using a structural and logics systems approach to infer bHLH-DNA binding specificity determinants, Federico De Masi, Christian A. Grove, Anastasia Vedenko, Andreu Alibés, Stephen S. Gisselbrecht, Luis Serrano, Martha L. Bulyk, and Albertha J. M. Walhout

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Endoplasmic reticulum stress and pancreatic beta-cell death, Sonya G. Fonseca, Jesper Gromada, and Fumihiko Urano

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Enhanced Y1H assays for Arabidopsis, Allison Gaudinier, Lifang Zhang, John S. Reece-Hoyes, Mallorie Taylor-Teeples, Li Pu, Zhijie Liu, Ghislain Breton, Jose L. Pruneda-Paz, Dahae Kim, Steve A. Kay, Albertha J. M. Walhout, Doreen Ware, and Siobhan M. Brady

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Body mass index-independent inflammation in omental adipose tissue associated with insulin resistance in morbid obesity, Olga T. Hardy, Richard A. Perugini, Sarah M. Nicoloro, Karen A. Gallagher-Dorval, Vishwajeet Puri, Juerg R. Straubhaar, and Michael P. Czech

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A unified taxonomy for ciliary dyneins, Erik F. Y. Hom, George B. Witman, Elizabeth H. Harris, Susan K. Dutcher, Ritsu Kamiya, David R. Mitchell, Gregory J. Pazour, Mary E. Porter, Winfield S. Sale, Maureen Wirschell, Toshiki Yagi, and Stephen M. King

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The COPI vesicle complex binds and moves with survival motor neuron within axons, Cyril P. Jayakumar, Matthew C. Evans, Venugopal Thayanithy, Naoko Taniguchi-Ishigaki, Ingolf Bach, Adrianne L. Kolpak, Gary J. Bassell, Rossoll Wilfried, Christian L. Lorson, Zheng-Zheng Bao, and Elliot J. Androphy

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Genome surveyor 2.0: cis-regulatory analysis in Drosophila, Majid Kazemian, Michael H. Brodsky, and Saurabh Sinha

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Adaptation to P element transposon invasion in Drosophila melanogaster, Jaspreet S. Khurana, Jie Wang, Jia Xu, Birgit S. Koppetsch, Travis Thomson, Anetta Nowosielska, Chengjian Li, Phillip D. Zamore, Zhiping Weng, and William E. Theurkauf

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Genotypic and functional properties of early infant HIV-1 envelopes, Michael G. Kishko, Mohan Somasundaran, Frank E. Brewster, John L. Sullivan, Paul R. Clapham, and Katherine Luzuriaga

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Midbody accumulation through evasion of autophagy contributes to cellular reprogramming and tumorigenicity, Tse-Chun Kuo, Chun-Ting Chen, Desiree Baron, Tamer T. Onder, Sabine Loewer, Sandra Almeida, Cara M. Weismann, Ping Xu, JeanMarie Houghton, Fen-Biao Gao, George Q. Daley, and Stephen J. Doxsey

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Gene regulatory networks and the role of robustness and stochasticity in the control of gene expression, Lesley T. MacNeil and Albertha J. M. Walhout

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Dicer is required for the formation of white but not brown adipose tissue, Rajini R. Mudhasani, Vishwajeet Puri, Kathleen Hoover, Michael P. Czech, Anthony N. Imbalzano, and Stephen N. Jones

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A conserved determinant in the V1 loop of HIV-1 modulates the V3 loop to prime low CD4 use and macrophage infection, Thomas A. Musich, Paul J. Peters, Maria J. Duenas-Decamp, Maria Paz Gonzalez-Perez, James E. Robinson, Susan Zolla-Pazner, Jonathan K. Ball, Katherine Luzuriaga, and Paul R. Clapham

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PDP-1 Links the TGF-β and IIS Pathways to Regulate Longevity, Development, and Metabolism, Sri Devi Narasimhan, Kelvin Yen, Ankita Bansal, Eun-Soo Kwon, Srivatsan Padmanabhan, and Heidi A. Tissenbaum

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The Plasma Membrane-Associated GTPase Rin Interacts with the Dopamine Transporter and Is Required for Protein Kinase C-Regulated Dopamine Transporter Trafficking, Deanna M. Navaroli, Zachary H. Stevens, Zeljko Uzelac, Luke Gabriel, Michael J. King, Lawrence M. Lifshitz, Harald H. Sitte, and Haley E. Melikian

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Effect of therapeutic HIV recombinant poxvirus vaccines on the size of the resting CD4+ T-cell latent HIV reservoir, Deborah Persaud, Katherine Luzuriaga, Carrie Ziemniak, Petronella Muresan, Thomas Greenough, Terry Fenton, Amanda Blackford, Kimberly Ferguson, Natalie Neu, and Coleen K. Cunningham

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Yeast one-hybrid assays for gene-centered human gene regulatory network mapping, John S. Reece-Hoyes, A. Rasim Barutcu, Rachel Patton McCord, Jun Seop Jeong, Lizhi Jiang, Andrew Macwilliams, Xinping Yang, Kourosh Salehi-Ashtiani, David E. Hill, Seth Blackshaw, Heng Zhu, Job Dekker, and Albertha J. M. Walhout

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Enhanced yeast one-hybrid assays for high-throughput gene-centered regulatory network mapping, John S. Reece-Hoyes, Alos Diallo, Bryan R. Lajoie, Amanda Kent, Shaleen Shrestha, Sreenath Kadreppa, Colin Pesyna, Job Dekker, Chad L. Myers, and Albertha J. M. Walhout

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BCR-ABL suppresses autophagy through ATF5-mediated regulation of mTOR transcription, Zhi Sheng, Leyuan Ma, Jiaoyuan Sun, Lihua Julie Zhu, and Michael R. Green

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Transcription factor Lhx2 is necessary and sufficient to suppress astrogliogenesis and promote neurogenesis in the developing hippocampus, Lakshmi Subramanian, Anindita Sarkar, Ashwin S. Shetty, Bhavana Muralidharan, Hari Padmanabhan, Michael Piper, Edwin S. Monuki, Ingolf Bach, Richard M. Gronostajski, Linda J. Richards, and Shubha Tole

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Chromosome-Biased Binding and Gene Regulation by the Caenorhabditis elegans DRM Complex, Tomoko M. Tabuchi, Bart Deplancke, Naoki Osato, Lihua Julie Zhu, Inmaculada M. Barrasa, Melissa M. Harrison, Robert H. Horvitz, Albertha J. M. Walhout, and Kirsten A. Hagstrom

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Glucan particles for selective delivery of siRNA to phagocytic cells in mice, Gregory J. Tesz, Myriam Aouadi, Matthieu Prot, Sarah M. Nicoloro, Emilie Boutet, Shinya U. Amano, Anca Goller, Mengxi Wang, Chang-An Guo, William E. Salomon, Joseph V. Virbasius, Rebecca A. Baum, Mark J. O'Connor, Ernesto Soto, Gary R. Ostroff, and Michael P. Czech

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The IRE1alpha-XBP1 pathway is essential for osteoblast differentiation through promoting transcription of Osterix, Takahide Tohmonda, Yoshiteru Miyauchi, Rajarshi Ghosh, Masaki Yoda, Shinichi Uchikawa, Jiro Takito, Hideo Morioka, Masaya Nakamura, Takao Iwawaki, Kazuhiro Chiba, Yoshiaki Toyama, Fumihiko Urano, and Keisuke Horiuchi

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Thoughts on aneuploidy, Eduardo M. Torres, Bret R. Williams, Yun-Chi Tang, and Angelika Amon

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Gene-centered regulatory network mapping, Albertha J. M. Walhout

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What does biologically meaningful mean? A perspective on gene regulatory network validation, Albertha J. M. Walhout

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RNF34 is a cold-regulated E3 ubiquitin ligase for PGC-1alpha and modulates brown fat cell metabolism, Ping Wei, Dongning Pan, Chunxiao Mao, and Yong-Xu Wang

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MicroRNA-regulated, systemically delivered rAAV9: a step closer to CNS-restricted transgene expression, Jun Xie, Qing Xie, Hongwei Zhang, Stefan L. Ameres, Jui-Hung Hung, Qin Su, Ran He, Xin Mu, Seemin Seher Ahmed, Soyeon Park, Hiroki Kato, Chengjian Li, Christian Mueller, Craig C. Mello, Zhiping Weng, Terence R. Flotte, Phillip D. Zamore, and Guangping Gao

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Mbd3/NURD complex regulates expression of 5-hydroxymethylcytosine marked genes in embryonic stem cells, Ozlem Yildirim, Ruowang Li, Jui-Hung Hung, Poshen B. Chen, Xianjun Dong, Ly-Sha Ee, Zhiping Weng, Oliver J. Rando, and Thomas G. Fazzio

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Sphingosine kinases and their metabolites modulate endolysosomal trafficking in photoreceptors, Ikuko Yonamine, Takeshi Bamba, Niraj K. Nirala, Nahid Jesmin, Teresa Kosakowska-Cholody, Kunio Nagashima, Eiichiro Fukasaki, Jairaj K. Acharya, and Usha Acharya

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Heterotypic piRNA Ping-Pong requires qin, a protein with both E3 ligase and Tudor domains, Zhao Zhang, Jia Xu, Birgit S. Koppetsch, Jie Wang, Cindy Tipping, Shengmei Ma, Zhiping Weng, William E. Theurkauf, and Phillip D. Zamore

Publications from 2010

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In the tradition of science: an interview with Victor Ambros, Victor R. Ambros

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Alterations in urine, serum and brain metabolomic profiles exhibit sexual dimorphism during malaria disease progression, Angika Basant, Mayuri Rege, Shobhona Sharma, and Haripalsingh M. Sonawat

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Human immune system development and rejection of human islet allografts in spontaneously diabetic NOD-Rag1null IL2rgammanull Ins2Akita mice, Michael A. Brehm, Rita Bortell, Philip J. Diiorio, Jean H. Leif, Joseph Laning, Amy Cuthbert, Chaoxing Yang, Mary Herlihy, Lisa M. Burzenski, Bruce Gott, Oded Foreman, Alvin C. Powers, Dale L. Greiner, and Leonard D. Shultz

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Parameters for establishing humanized mouse models to study human immunity: analysis of human hematopoietic stem cell engraftment in three immunodeficient strains of mice bearing the IL2rgamma(null) mutation, Michael A. Brehm, Amy Cuthbert, Chaoxing Yang, David M. Miller, Philip J. Diiorio, Joseph Laning, Lisa M. Burzenski, Bruce Gott, Oded Foreman, Anoop Kavirayani, Mary Herlihy, Aldo A. Rossini, Leonard D. Shultz, and Dale L. Greiner

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Argonautes ALG-3 and ALG-4 are required for spermatogenesis-specific 26G-RNAs and thermotolerant sperm in Caenorhabditis elegans., Colin C. Conine, Pedro J. Batista, Weifeng Gu, Julie M. Claycomb, Daniel A. Chaves, Masaki Shirayama, and Craig C. Mello

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miR-21 and miR-31 Converge on TIAM1 to Regulate Migration and Invasion of Colon Carcinoma Cells, Charisa L. Cottonham, Satoshi Kaneko, and Lan Xu

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Wolfram syndrome 1 gene negatively regulates ER stress signaling in rodent and human cells, Sonya G. Fonseca, Shinsuke Ishigaki, Christine M. Oslowski, Simin Lu, Kathryn L. Lipson, Rajarshi Ghosh, Emiko Hayashi, Hisamitsu Ishihara, Yoshitomo Oka, M. Alan Permutt, and Fumihiko Urano

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Transcriptional regulation of VEGF-A by the unfolded protein response pathway, Rajarshi Ghosh, Kathryn L. Lipson, Karen E. Sargent, Arthur M. Mercurio, Joan S. Hunt, David Ron, and Fumihiko Urano

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Programmed Death-1 expression on Epstein Barr virus specific CD8+ T cells varies by stage of infection, epitope specificity, and T-cell receptor usage, Thomas C. Greenough, Shalyn C. Campellone, Robin M. Brody, Surbhi Jain, Victor Sanchez-Merino, Mohan Somasundaran, and Katherine Luzuriaga

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p53 represses class switch recombination to IgG2a through its antioxidant function, Jeroen E. J. Guikema, Carol E. Schrader, Michael H. Brodsky, Erin K. Linehan, Adam Richards, Nahla El Falaky, Daniel H. LI, Hayla Karen Sluss, Eva Szomolanyi-Tsuda, and Janet Stavnezer

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AATF mediates an antiapoptotic effect of the unfolded protein response through transcriptional regulation of AKT1, Shinsuke Ishigaki, Sonya G. Fonseca, Christine M. Oslowski, Agata Jurczyk, Jeffrey R. Shearstone, Lihua Julie Zhu, M. A. Permutt, Dale L. Greiner, Fumihiko Urano, and Rita Bortell

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Setdb1 histone methyltransferase regulates mood-related behaviors and expression of the NMDA receptor subunit NR2B, Yan Jiang, Mira Jakovcevski, Rahul Bharadwaj, Caroline M. Connor, Frederick Albert Schroeder, Cong L. Lin, Juerg R. Straubhaar, Gilles E. Martin, and Schahram Akbarian

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CPEB4 is a cell survival protein retained in the nucleus upon ischemia or endoplasmic reticulum calcium depletion, Ming-Chung Kan, Aparna Oruganty-Das, Amalene Cooper-Morgan, Guang Jin, Sharon A. Swanger, Gary J. Bassell, Harvey M. Florman, Klaus van Leyen, and Joel D. Richter

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Modulation of HIV-1 macrophage-tropism among R5 envelopes occurs before detection of neutralizing antibodies, Kathryn H. Richards, Marlen M.I. Aasa-Chapman, Aine McKnight, and Paul R. Clapham

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Maternal Rnf12/RLIM is required for imprinted X-chromosome inactivation in mice, JongDae Shin, Michael Bossenz, Young Chung, Hong Ma, Meg Byron, Naoko Taniguchi-Ishigaki, Xiaochun Zhu, Jiao Baowei, Lisa L. Hall, Michael R. Green, Stephen N. Jones, Irm Hermans-Borgmeyer, Jeanne B. Lawrence, and Ingolf Bach

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Identification of aneuploidy-tolerating mutations, Eduardo M. Torres, Noah Dephoure, Amudha Panneerselvam, Cheryl M. Tucker, Charles A. Whittaker, Steven P. Gygi, Maitreya J. Dunham, and Angelika Amon

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Role for IGFBP7 in senescence induction by BRAF., Narendra Wajapeyee, Ryan W. Serra, Xiaochun Zhu, Meera Mahalingam, and Michael R. Green

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Senescence induction in human fibroblasts and hematopoietic progenitors by leukemogenic fusion proteins., Narendra Wajapeyee, Shu-Zong Wang, Ryan W. Serra, Peter D. Solomon, Arvindhan Nagarajan, Xiaochun Zhu, and Michael R. Green

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Inhibiting miRNA in Caenorhabditis elegans using a potent and selective antisense reagent, Genhua Zheng, Victor R. Ambros, and Wen-hong Li

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ChIPpeakAnno: a Bioconductor package to annotate ChIP-seq and ChIP-chip data, Lihua Julie Zhu, Claude Gazin, Nathan D. Lawson, Herve Pages, Simon M. Lin, David S. Lapointe, and Michael R. Green

Publications from 2009

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Depletion of the programmed death-1 receptor completely reverses established clonal anergy in CD4(+) T lymphocytes via an interleukin-2-dependent mechanism, Kenneth D. Bishop, John E. Harris, John P. Mordes, Dale L. Greiner, Aldo A. Rossini, Michael P. Czech, and Nancy E. Phillips

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Induction of hepatitis by JNK-mediated expression of TNF-alpha, Madhumita Das, Guadalupe Sabio, Feng Jiang, Mercedes Rincon, Richard A. Flavell, and Roger J. Davis

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nhl-2 Modulates microRNA activity in Caenorhabditis elegans, Christopher M. Hammell, Isabella Lubin, Peter R. Boag, T. Keith Blackwell, and Victor R. Ambros

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The Chlamydomonas reinhardtii BBSome is an IFT cargo required for export of specific signaling proteins from flagella, Karl-Ferdinand Lechtreck, Eric C. Johnson, Tsuyoshi Sakai, Deborah A. Cochran, Bryan A. Ballif, John Rush, Gregory J. Pazour, Mitsuo Ikebe, and George B. Witman

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Suppression of Ca2+ syntillas increases spontaneous exocytosis in mouse adrenal chromaffin cells, Jason J. Lefkowitz, Kevin E. Fogarty, Lawrence M. Lifshitz, Karl D. Bellve, Richard A. Tuft, Ronghua ZhuGe, John V. Walsh Jr., and Valerie De Crescenzo

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Mcl-1 integrates the opposing actions of signaling pathways that mediate survival and apoptosis, Caroline Morel, Scott M. Carlson, Forest M. White, and Roger J. Davis

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A PP2A regulatory subunit regulates C. elegans insulin/IGF-1 signaling by modulating AKT-1 phosphorylation., Srivatsan Padmanabhan, Arnab Mukhopadhyay, Sri Devi Narasimhan, Gregory J. Tesz, Michael P. Czech, and Heidi A. Tissenbaum

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Signal transduction cross talk mediated by Jun N-terminal kinase-interacting protein and insulin receptor substrate scaffold protein complexes, Claire L. Standen, Norman J. Kennedy, Richard A. Flavell, and Roger J. Davis

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Systematic analysis of dynamic miRNA-target interactions during C. elegans development, Liang Zhang, Molly Hammell, Brian A. Kudlow, Victor R. Ambros, and Min Han

Publications from 2008

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PRG-1 and 21U-RNAs interact to form the piRNA complex required for fertility in C. elegans, Pedro J. Batista, J. Graham Ruby, Julie M. Claycomb, H. Rosaria Chiang, Noah Fahlgren, Kristin D. Kasschau, Daniel A. Chaves, Weifeng Gu, Jessica J. Vasale, Shenghua Duan, Darryl Conte, Shujun Luo, Gary P. Schroth, James C. Carrington, David P. Bartel, and Craig C. Mello

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The insulator binding protein CTCF positions 20 nucleosomes around its binding sites across the human genome, Yutao Fu, Manisha Sinha, Craig L. Peterson, and Zhiping Weng

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A Rictor-Myo1c complex participates in dynamic cortical actin events in 3T3-L1 adipocytes, G. Nana Hagan, Yenshou Lin, Mark A. Magnuson, Joseph Avruch, and Michael P. Czech

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Multisite phosphorylation regulates Bim stability and apoptotic activity, Anette Hubner, Tamera Barrett, Richard A. Flavell, and Roger J. Davis

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Sorting of EGF and transferrin at the plasma membrane and by cargo-specific signaling to EEA1-enriched endosomes, Deborah Leonard, Akira Hayakawa, Deirdre C. Lawe, David G. Lambright, Karl D. Bellve, Clive Standley, Lawrence M. Lifshitz, Kevin E. Fogarty, and Silvia Corvera

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The role of IRE1alpha in the degradation of insulin mRNA in pancreatic beta-cells, Kathryn L. Lipson, Rajarshi Ghosh, and Fumihiko Urano