Publications from 2009
Mcl-1 integrates the opposing actions of signaling pathways that mediate survival and apoptosis, Caroline Morel, Scott M. Carlson, Forest M. White, and Roger J. Davis
A PP2A regulatory subunit regulates C. elegans insulin/IGF-1 signaling by modulating AKT-1 phosphorylation., Srivatsan Padmanabhan, Arnab Mukhopadhyay, Sri Devi Narasimhan, Gregory J. Tesz, Michael P. Czech, and Heidi A. Tissenbaum
Signal transduction cross talk mediated by Jun N-terminal kinase-interacting protein and insulin receptor substrate scaffold protein complexes, Claire L. Standen, Norman J. Kennedy, Richard A. Flavell, and Roger J. Davis
Systematic analysis of dynamic miRNA-target interactions during C. elegans development, Liang Zhang, Molly Hammell, Brian A. Kudlow, Victor R. Ambros, and Min Han
Publications from 2008
PRG-1 and 21U-RNAs interact to form the piRNA complex required for fertility in C. elegans, Pedro J. Batista, J. Graham Ruby, Julie M. Claycomb, H. Rosaria Chiang, Noah Fahlgren, Kristin D. Kasschau, Daniel A. Chaves, Weifeng Gu, Jessica J. Vasale, Shenghua Duan, Darryl Conte, Shujun Luo, Gary P. Schroth, James C. Carrington, David P. Bartel, and Craig C. Mello
A Rictor-Myo1c complex participates in dynamic cortical actin events in 3T3-L1 adipocytes, G. Nana Hagan, Yenshou Lin, Mark A. Magnuson, Joseph Avruch, and Michael P. Czech
Multisite phosphorylation regulates Bim stability and apoptotic activity, Anette Hubner, Tamera Barrett, Richard A. Flavell, and Roger J. Davis
Sorting of EGF and transferrin at the plasma membrane and by cargo-specific signaling to EEA1-enriched endosomes, Deborah Leonard, Akira Hayakawa, Deirdre C. Lawe, David G. Lambright, Karl D. Bellve, Clive Standley, Lawrence M. Lifshitz, Kevin E. Fogarty, and Silvia Corvera
The role of IRE1alpha in the degradation of insulin mRNA in pancreatic beta-cells, Kathryn L. Lipson, Rajarshi Ghosh, and Fumihiko Urano
A C. elegans genome-scale microRNA network contains composite feedback motifs with high flux capacity, Natalia Julia Martinez, Maria C. Ow, M. Inmaculada Barrasa, Molly Hammell, Reynaldo Sequerra, Lynn Doucette-Stamm, Frederick P. Roth, Victor R. Ambros, and Albertha J. M. Walhout
Genome-scale spatiotemporal analysis of Caenorhabditis elegans microRNA promoter activity, Natalia Julia Martinez, Maria C. Ow, John S. Reece-Hoyes, M. Inmaculada Barrasa, Victor R. Ambros, and Albertha J. M. Walhout
The FLYWCH transcription factors FLH-1, FLH-2, and FLH-3 repress embryonic expression of microRNA genes in C. elegans, Maria C. Ow, Natalia Julia Martinez, Philip H. Olsen, Howard S. Silverman, M. Inmaculada Barrasa, Barbara Conradt, Albertha J. M. Walhout, and Victor R. Ambros
Lipid droplets: FSP27 knockout enhances their sizzle, Vishwajeet Puri and Michael P. Czech
Cidea is associated with lipid droplets and insulin sensitivity in humans, Vishwajeet Puri, Srijana Ranjit, Silvana Konda, Sarah M. Nicoloro, Juerg R. Straubhaar, Anil Chawla, My T. Chouinard, Chenyi Lin, Alison Burkart, Silvia Corvera, Richard A. Perugini, and Michael P. Czech
A stress signaling pathway in adipose tissue regulates hepatic insulin resistance, Guadalupe Sabio, Madhumita Das, Alfonso Mora, Zhiyou Zhang, John Y. Jun, Hwi Jin Ko, Tamera Barrett, Jason K. Kim, and Roger J. Davis
Paradoxical effect of mitochondrial respiratory chain impairment on insulin signaling and glucose transport in adipose cells, Xiarong Shi, Alison Burkart, Sarah M. Nicoloro, Michael P. Czech, Juerg R. Straubhaar, and Silvia Corvera
Akt substrate TBC1D1 regulates GLUT1 expression through the mTOR pathway in 3T3-L1 adipocytes, Qiong L. Zhou, Zhen Y. Jiang, John Holik, Anil Chawla, G. Nana Hagan, John D. Leszyk, and Michael P. Czech
Publications from 2007
Stearoyl-CoA desaturase 2 is required for peroxisome proliferator-activated receptor gamma expression and adipogenesis in cultured 3T3-L1 cells, Jennifer L. Christianson, Sarah M. Nicoloro, Juerg R. Straubhaar, and Michael P. Czech
Suppression of p53-dependent senescence by the JNK signal transduction pathway, Madhumita Das, Feng Jiang, Hayla Karen Sluss, Chao Zhang, Kevan M. Shokat, Richard A. Flavell, and Roger J. Davis
Structural basis for Rab GTPase activation by VPS9 domain exchange factors, Anna M. Delprato and David G. Lambright
Structural basis and mechanism of autoregulation in 3-phosphoinositide-dependent Grp1 family Arf GTPase exchange factors, Jonathan P. DiNitto, Anna M. Delprato, Meng-Tse Gabe Lee, Thomas Charles Cronin, Shaohui Huang, Adilson L. Guilherme, Michael P. Czech, and David G. Lambright
Evolutionarily conserved structural and functional roles of the FYVE domain, Akira Hayakawa, Susan J. Hayes, Deborah Marie Leonard, David G. Lambright, and Silvia Corvera
Insulin stimulates membrane fusion and GLUT4 accumulation in clathrin coats on adipocyte plasma membranes, Shaohui Huang, Lawrence M. Lifshitz, Christine Jones, Karl D. Bellve, Clive Standley, Sonya G. Fonseca, Silvia Corvera, Kevin E. Fogarty, and Michael P. Czech
Metabolic stress signaling mediated by mixed-lineage kinases, Anja Jaeschke and Roger J. Davis
A radical role for p38 MAPK in tumor initiation, Norman J. Kennedy, Cristina Arrigo Cellurale, and Roger J. Davis
Structural insights into the interaction of the evolutionarily conserved ZPR1 domain tandem with eukaryotic EF1A, receptors, and SMN complexes, Ashwini K. Mishra, Laxman Gangwani, Roger J. Davis, and David G. Lambright
Fat-specific protein 27, a novel lipid droplet protein that enhances triglyceride storage, Vishwajeet Puri, Silvana Konda, Srijana Ranjit, Myriam Aouadi, Anil Chawla, My T. Chouinard, Abhijit Chakladar, and Michael P. Czech
Tumor necrosis factor alpha (TNFalpha) stimulates Map4k4 expression through TNFalpha receptor 1 signaling to c-Jun and activating transcription factor 2, Gregory J. Tesz, Adilson L. Guilherme, Kalyani V. P. Guntur, Andrea C. Hubbard, Xiaoqing Tang, Anil Chawla, and Michael P. Czech
Publications from 2006
Deficiency of the zinc finger protein ZPR1 causes neurodegeneration, Beth Doran, Norberto G. Gherbesi, Gregory M. Hendricks, Richard A. Flavell, Roger J. Davis, and Laxman Gangwani
Functional proteomics reveals the biochemical niche of C. elegans DCR-1 in multiple small-RNA-mediated pathways, Thomas F. Duchaine, James A. Wohlschlegel, Scott Kennedy, Yanxia Bei, Darryl Conte, Ka Ming Pang, Daniel R. Brownell, Sandra Harding, Shohei Mitani, Gary Ruvkun, John R. Yates, and Craig C. Mello
The Intraflagellar Transport Protein IFT20 Is Associated with the Golgi Complex and Is Required for Cilia Assembly, John A. Follit, Richard A. Tuft, Kevin E. Fogarty, and Gregory J. Pazour
Control of cellular senescence by CPEB, Irina Groisman, Maria Ivshina, Veronica Marin, Norman J. Kennedy, Roger J. Davis, and Joel D. Richter
The WD40 and FYVE domain containing protein 2 defines a class of early endosomes necessary for endocytosis, Akira Hayakawa, Deborah Marie Leonard, Stephanie Murphy, Susan J. Hayes, Martha C. Soto, Kevin E. Fogarty, Clive Standley, Karl D. Bellve, David G. Lambright, Craig C. Mello, and Silvia Corvera
RNAi-based gene silencing in primary mouse and human adipose tissues, Vishwajeet Puri, Abhijit Chakladar, Joseph V. Virbasius, Silvana Konda, Aimee M. Powelka, My T. Chouinard, G. Nana Hagan, Richard A. Perugini, and Michael P. Czech
An RNA interference-based screen identifies MAP4K4/NIK as a negative regulator of PPARgamma, adipogenesis, and insulin-responsive hexose transport, Xiaoqing Tang, Adilson L. Guilherme, Abhijit Chakladar, Aimee M. Powelka, Silvana Konda, Joseph V. Virbasius, Sarah M. Nicoloro, Juerg R. Straubhaar, and Michael P. Czech
Analysis of the C. elegans Argonaute family reveals that distinct Argonautes act sequentially during RNAi, Erbay Yigit, Pedro J. Batista, Yanxia Bei, Ka Ming Pang, Chun-Chieh G. Chen, Niraj H. Tolia, Leemor Joshua-Tor, Shohei Mitani, Martin J. Simard, and Craig C. Mello
Publications from 2005
Role of MLK3 in the regulation of mitogen-activated protein kinase signaling cascades, Deborah Marie Brancho, Juan-Jose Ventura, Anja Jaeschke, Beth Doran, Richard A. Flavell, and Roger J. Davis
A member of the polymerase beta nucleotidyltransferase superfamily is required for RNA interference in C. elegans, Chun-Chieh G. Chen, Martin J. Simard, Hiroaki Tabara, Daniel R. Brownell, Jennifer A. McCollough, and Craig C. Mello
The anaphase promoting complex: a critical target for viral proteins and anti-cancer drugs, Destin W. Heilman, Michael R. Green, and Jose G. Teodoro
Effects of HMGN1 on chromatin structure and SWI/SNF-mediated chromatin remodeling, David A. Hill, Craig L. Peterson, and Anthony N. Imbalzano
Disruption of the Jnk2 (Mapk9) gene reduces destructive insulitis and diabetes in a mouse model of type I diabetes, Anja Jaeschke, Mercedes Rincon, Beth Doran, Judith Reilly, Donna S. Neuberg, Dale L. Greiner, Leonard D. Shultz, Aldo A. Rossini, Richard A. Flavell, and Roger J. Davis
Wnt signaling drives WRM-1/beta-catenin asymmetries in early C. elegans embryos, Tatsuya Nakamura, Soyoung Kim, Takao Ishidate, Yanxia Bei, Ka Ming Pang, Masaki Shirayama, Chris Trzepacz, Daniel R. Brownell, and Craig C. Mello
HIV-1-specific CD8+ T cell responses and viral evolution in women and infants, Victor Sanchez-Merino, Siwei Nie, and Katherine Luzuriaga
The Conserved Kinases CDK-1, GSK-3, KIN-19, and MBK-2 Promote OMA-1 Destruction to Regulate the Oocyte-to-Embryo Transition in C. elegans, Masaki Shirayama, Martha C. Soto, Takao Ishidate, Soyoung Kim, Kuniaki Nakamura, Yanxia Bei, Sander van den Heuvel, and Craig C. Mello
Publications from 2004
The Caenorhabditis elegans IMPAS gene, imp-2, is essential for development and is functionally distinct from related presenilins, Anastasia P. Grigorenko, Yuri K. Moliaka, Martha C. Soto, Craig C. Mello, and Evgeny I. Rogaev
Phosphatidylinositol-4,5-bisphosphate-rich plasma membrane patches organize active zones of endocytosis and ruffling in cultured adipocytes, Shaohui Huang, Lawrence M. Lifshitz, Varsha Patki, Richard A. Tuft, Kevin E. Fogarty, and Michael P. Czech
Sequence-specific inhibition of small RNA function, Gyorgy Hutvagner, Martin J. Simard, Craig C. Mello, and Phillip D. Zamore
Publications from 2003
MEP-1 and a homolog of the NURD complex component Mi-2 act together to maintain germline-soma distinctions in C. elegans, Yingdee Unhavaithaya, Tae Ho Shin, Nicholas B. Miliaras, Jungsoon Lee, Tomoko Oyama, and Craig C. Mello
Publications from 2002
SRC-1 and Wnt signaling act together to specify endoderm and to control cleavage orientation in early C. elegans embryos, Yanxia Bei, Jennifer Hogan, Laura A. Berkowitz, Martha C. Soto, Christian Ernest Rocheleau, Ka Ming Pang, John J. Collins, and Craig C. Mello
RNAi (Nematodes: Caenorhabditis elegans), Alla Grishok and Craig C. Mello
The GEX-2 and GEX-3 proteins are required for tissue morphogenesis and cell migrations in C. elegans, Martha C. Soto, Hiroshi Qadota, Katsuhisa Kasuya, Makiko Inoue, Daisuke Tsuboi, Craig C. Mello, and Kozo Kaibuchi
Publications from 2001
Genes and mechanisms related to RNA interference regulate expression of the small temporal RNAs that control C. elegans developmental timing, Alla Grishok, Amy E. Pasquinelli, Darryl Conte Jr., Na Li, Susan Parrish, Ilho Ha, David L. Baillie, Andrew Z. Fire, Gary Ruvkun, and Craig C. Mello
HAT activity is essential for CBP-1-dependent transcription and differentiation in Caenorhabditis elegans, Martin Victor, Yanxia Bei, Frederique Gay, Dominica Calvo, Craig C. Mello, and Yang Shi
Publications from 2000
Genetic requirements for inheritance of RNAi in C. elegans, Alla Grishok, Hiroaki Tabara, and Craig C. Mello
Publications from 1999
The mesoderm determinant snail collaborates with related zinc-finger proteins to control Drosophila neurogenesis, Shovon Imtiaz Ashraf, Xiaodi Hu, John Roote, and Y. Tony Ip
WRM-1 activates the LIT-1 protein kinase to transduce anterior/posterior polarity signals in C. elegans, Christian Ernest Rocheleau, Jun Yasuda, Tae Ho Shin, Rueyling Lin, Hitoshi Sawa, Hideyuki Okano, James R. Priess, Roger J. Davis, and Craig C. Mello
MOM-4, a MAP kinase kinase kinase-related protein, activates WRM-1/LIT-1 kinase to transduce anterior/posterior polarity signals in C. elegans, Tae Ho Shin, Jun Yasuda, Christian Ernest Rocheleau, Rueyling Lin, Martha C. Soto, Yanxia Bei, Roger J. Davis, and Craig C. Mello
The rde-1 gene, RNA interference, and transposon silencing in C. elegans, Hiroaki Tabara, Madathia Sarkissian, William G. Kelly, Jamie Fleenor, Alla Grishok, Lisa Timmons, Andrew Z. Fire, and Craig C. Mello
Publications from 1998
RNAi in C. elegans: soaking in the genome sequence, Hiroaki Tabara, Alla Grishok, and Craig C. Mello
Publications from 1997
Wnt signaling and an APC-related gene specify endoderm in early C. elegans embryos, Christian Ernest Rocheleau, William D. Downs, Rueyling Lin, Claudia Wittman, Yanxia Bei, Yoon-Hee Cha, Mussa Ali, James R. Priess, and Craig C. Mello