Title

A PH Domain with Dual Phospholipid Binding Sites Regulates the ARF GAP, ASAP1

UMMS Affiliation

Program in Molecular Medicine; Department of Biochemistry and Molecular Pharmacology

Date

11-3-2015

Document Type

Article

Disciplines

Biochemistry | Molecular Biology | Structural Biology

Abstract

In this issue of Structure, Jian et al. (2015) report the crystal structures of the apo- and dibutyryl-PI(4,5)P2 bound forms of the PH domain from the ARF GAP, ASAP1. This PH domain has two anionic phospholipid binding sites proposed to work in concert to regulate ASAP1 GAP activity.

Rights and Permissions

Citation: Structure. 2015 Nov 3;23(11):1971-3. doi: 10.1016/j.str.2015.10.002. Link to article on publisher's site

Related Resources

Link to Article in PubMed

PubMed ID

26536378