Developmental decline in neuronal regeneration by the progressive change of two intrinsic timers
Document Type
Journal ArticlePublication Date
2013-04-19Keywords
AgingAnimals
Axons
Caenorhabditis elegans
Caenorhabditis elegans Proteins
MicroRNAs
Microtubules
Nerve Regeneration
Neurogenesis
Neurons
RNA-Binding Proteins
Transcription Factors
Biochemistry
Developmental Biology
Developmental Neuroscience
Molecular Biology
Molecular Genetics
Metadata
Show full item recordAbstract
Like mammalian neurons, Caenorhabditis elegans neurons lose axon regeneration ability as they age, but it is not known why. Here, we report that let-7 contributes to a developmental decline in anterior ventral microtubule (AVM) axon regeneration. In older AVM axons, let-7 inhibits regeneration by down-regulating LIN-41, an important AVM axon regeneration-promoting factor. Whereas let-7 inhibits lin-41 expression in older neurons through the lin-41 3' untranslated region, lin-41 inhibits let-7 expression in younger neurons through Argonaute ALG-1. This reciprocal inhibition ensures that axon regeneration is inhibited only in older neurons. These findings show that a let-7-lin-41 regulatory circuit, which was previously shown to control timing of events in mitotic stem cell lineages, is reutilized in postmitotic neurons to control postdifferentiation events.Source
Science. 2013 Apr 19;340(6130):372-6. doi: 10.1126/science.1231321. Link to article on publisher's site
DOI
10.1126/science.1231321Permanent Link to this Item
http://hdl.handle.net/20.500.14038/44433PubMed ID
23599497Related Resources
Link to Article in PubMedae974a485f413a2113503eed53cd6c53
10.1126/science.1231321