The Program in Molecular Medicine at the University of Massachusetts Medical School was established in a new research building in 1989. Faculty include both clinical investigators and basic scientists, many of whom focus their research on human disease processes. The laboratory groups and core facilities that compose Molecular Medicine represent many disciplines in the bio-medical sciences: biochemistry and molecular biology, cell biology, medicine, immunology, molecular genetics and microbiology, pediatrics, pharmacology, physiology, genomics, bioinformatics and proteomics. This diverse scientific environment makes the Program an exceptional training ground for graduate students and postdoctoral fellows, who in turn contribute much to its vitality and excitement. This collection showcases publications and presentations written by faculty and researchers of the Program in Molecular Medicine.

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Publications from 2017

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Metabolic network modeling with model organisms, L. Safak Yilmaz and Albertha J. M. Walhout (Current opinion in chemical biology)

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C. elegans and its bacterial diet as a model for systems-level understanding of host-microbiota interactions, Jing Zhang, Amy D. Holdorf, and Albertha J. M. Walhout (Current opinion in biotechnology)

Publications from 2016

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A Modular Assembly Platform for Rapid Generation of DNA Constructs, Elliot Akama-Garren, Nik Joshi, Tuomas Tammela, Gregory P. Chang, Bethany L. Wagner, Da-Yae Lee, William M. Rideout Iii, Thales Papagiannakopoulos, Wen Xue, and Tyler Jacks

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In vivo correction of anaemia in beta-thalassemic mice by gammaPNA-mediated gene editing with nanoparticle delivery, Raman Bahal, Dale L. Greiner, Michael A. Brehm, and Peter M. Glazer

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Factors influencing survival among Kenyan children diagnosed with endemic Burkitt lymphoma between 2003 and 2011: A historical cohort study, Geoffrey C. Buckle, Louise Maranda, Jodi Skiles, John Michael Ong'echa, Joslyn Foley, Mara M. Epstein, Terry A. Vik, Andrew Schroeder, Jennifer Lemberger, Alan G. Rosmarin, Scot C. Remick, Jeffrey A. Bailey, John Vulule, Juliana A. Otieno, and Ann M. Moormann

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ASM Journals Eliminate Impact Factor Information from Journal Websites, Arturo Casadevall, Roger J. Davis, and ASM Journal Editors and Leadership

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Evolutionary analysis across mammals reveals distinct classes of long non-coding RNAs, Jenny Chen, Alexander A. Shishkin, Xiaopeng Zhu, Sabah Kadri, Itay Maza, Mitchell Guttman, Jacob H. Hanna, Aviv Regev, and Manuel Garber

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HIV-1 capsid is involved in post-nuclear entry steps, Nan-Yu Chen, Lihong Zhou, Paul J. Gane, Silvana Opp, Neil J. Ball, Giuseppe Nicastro, Madeleine Zufferey, Cindy Buffone, Jeremy Luban, David Selwood, Felipe Diaz-Griffero, Ian Taylor, and Ariberto Fassati

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Peptide- and Amine-Modified Glucan Particles for the Delivery of Therapeutic siRNA, Jessica L. Cohen, Yuefei Shen, Myriam Aouadi, Pranitha Vangala, Michaela Tencerova, Shinya U. Amano, Sarah M. Nicoloro, Joseph Yawe, and Michael P. Czech

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Multipolar mitosis and aneuploidy after chrysotile treatment: a consequence of abscission failure and cytokinesis regression, Beatriz Araujo Cortez, Paula Rezende-Teixeira, Sambra D. Redick, Stephen J. Doxsey, and Glaucia Maria Machado-Santelli

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Combined Activities of JNK1 and JNK2 in Hepatocytes Protect Against Toxic Liver Injury, Francisco Javier Cubero, Miguel Eugenio Zoubek, Wei Hu, Jin Peng, Gang Zhao, Yulia A. Nevzorova, Malika Al Masaoudi, Lars P. Bechmann, Mark V. Boekschoten, Michael Muller, Christian Preisinger, Nikolaus Gassler, Ali E. Canbay, Tom Luedde, Roger J. Davis, Christian Liedtke, and Christian Trautwein

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The Effects of Interleukin-10 on Skeletal Muscle Insulin Resistance and Myogenesis, Sezin Dagdeviren

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IL-10 prevents aging-associated inflammation and insulin resistance in skeletal muscle, Sezin Dagdeviren, Dae Young Jung, Randall H. Friedline, Hye Lim Noh, Jong Hun Kim, Payal R. Patel, Nicholas Tsitsilianos, Kunikazu Inashima, Duy A. Tran, Xiaodi Hu, Marilia M. Loubato, Siobhan M. Craige, Jung Yeon Kwon, Ki Won. Lee, and Jason K. Kim

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Altered Interleukin-10 Signaling in Skeletal Muscle Regulates Obesity-Mediated Inflammation and Insulin Resistance, Sezin Dagdeviren, Dae Young Jung, Eunjung Lee, Randall H. Friedline, Hye Lim Noh, Jong Hun. Kim, Payal R. Patel, Nicholas Tsitsilianos, Andrew V. Tsitsilianos, Duy A. Tran, George H. Tsougranis, Caitlyn C. Kearns, Cecilia P. Uong, Jung Yeon. Kwon, Werner Muller, Ki Won. Lee, and Jason K. Kim

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The pesticidal Cry6Aa toxin from Bacillus thuringiensis is structurally similar to HlyE-family alpha pore-forming toxins, Alexey Dementiev, Anand Sitaram, Yan Hu, Raffi V. Aroian, and Colin Berry

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End Sequence Analysis ToolKit (ESAT) expands the extractable from single cell RNA-seq experiments, Alan G. Derr, Chaoxing Yang, Rapolas Zilionis, Alexey Sergushichev, David Blodgett, Sambra D. Redick, Rita Bortell, Jeremy Luban, David Harlan, Sebastian Kadener, Dale L. Greiner, Allon Klein, Maxim Artyomov, and Manuel Garber

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Adipocyte-specific Hypoxia-inducible gene 2 promotes fat deposition and diet-induced insulin resistance, Marina DiStefano, Rachel J. Roth Flach, Ozlem Senol-Cosar, Laura V. Danai, Joseph V. Virbasius, Sarah M. Nicoloro, Juerg R. Straubhaar, Sezin Dagdeviren, Martin Wabitsch, Olga T. Gupta, Jason K. Kim, and Michael P. Czech

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Dietary Betaine Supplementation Increases Fgf21 Levels to Improve Glucose Homeostasis and Reduce Hepatic Lipid Accumulation in Mice, Asma Ejaz, Jason K. Kim, Mary-Elizabeth Patti, and Carles Lerin

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Emerging evidence for beneficial macrophage functions in atherosclerosis and obesity-induced insulin resistance, Timothy P. Fitzgibbons and Michael P. Czech

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Genetic ablation of lymphocytes and cytokine signaling in nonobese diabetic mice prevents diet-induced obesity and insulin resistance, Randall H. Friedline, Hwi Jin Ko, Dae Young Jung, Yongjin Lee, Rita Bortell, Sezin Dagdeviren, Payal R. Patel, Xiaodi Hu, Kunikazu Inashima, Caitlyn C. Kearns, Nicholas Tsitsilianos, Umber Shafiq, Dale L. Greiner, and Jason K. Kim

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A gene-centered C. elegans protein-DNA interaction network provides a framework for functional predictions, Juan Fuxman Bass, Carles Pons, Lucie Kozlowski, John S. Reece-Hoyes, Shaleen Shrestha, Amy D. Holdorf, Akihiro Mori, Chad L. Myers, and Albertha J. M. Walhout

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Gene-Centered Yeast One-Hybrid Assays, Juan Fuxman Bass, John S. Reece-Hoyes, and Albertha J. Walhout M (Cold Spring Harbor protocols)

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Colony Lift Colorimetric Assay for beta-Galactosidase Activity, Juan Fuxman Bass, John S. Reece-Hoyes, and Albertha J. M. Walhout (Cold Spring Harbor protocols)

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Generating Bait Strains for Yeast One-Hybrid Assays, Juan Fuxman Bass, John S. Reece-Hoyes, and Albertha J. M. Walhout (Cold Spring Harbor protocols)

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Performing Yeast One-Hybrid Library Screens, Juan Fuxman Bass, John S. Reece-Hoyes, and Albertha J. M. Walhout (Cold Spring Harbor protocols)

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Zymolyase-Treatment and Polymerase Chain Reaction Amplification from Genomic and Plasmid Templates from Yeast, Juan Fuxman Bass, John S. Reece-Hoyes, and Albertha J. M. Walhout (Cold Spring Harbor protocols)

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Increased Glucose-induced Secretion of Glucagon-like Peptide-1 in Mice Lacking the Carcinoembryonic Antigen-related Cell Adhesion Molecule 2 (CEACAM2), Simona S. Ghanem, Dae Young Jung, Yongjin Lee, Jason K. Kim, and Sonia M. Najjar

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TNFalpha-Mediated Cytotoxic Responses to IAP Inhibition Are Limited by the p38alpha MAPK Pathway, Nomeda Girnius and Roger J. Davis

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The RNA-binding protein ATX-2 regulates cytokinesis through PAR-5 and ZEN-4, Megan M. Gnazzo, Eva-Maria E. Uhlemann, Alex R. Villarreal, Masaki Shirayama, Eddie G. Dominguez, and Ahna R. Skop

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P-Rex1 Promotes Resistance to VEGF/VEGFR-Targeted Therapy in Prostate Cancer, Hira Lal Goel, Bryan M. Pursell, Leonard D. Shultz, Dale L. Greiner, Rolf A. Brekken, Craig W. Vander Kooi, and Arthur M. Mercurio

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Inflammation Mediated by JNK in Myeloid Cells Promotes the Development of Hepatitis and Hepatocellular Carcinoma, Myoung Souk Han, Tamera Barrett, Michael A. Brehm, and Roger J. Davis

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Cell Signaling and Stress Responses, Gokhan S. Hotamisligil and Roger J. Davis

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The Mother Centriole Appendage Protein Cenexin Modulates Lumen Formation through Spindle Orientation, Hui-Fan Hung, Heidi Hehnly, and Stephen J. Doxsey

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Cardiac-Specific Disruption of GH Receptor Alters Glucose Homeostasis While Maintaining Normal Cardiac Performance in Adult Male Mice, Adam Jara, Xingbo Liu, Don Sim, Chance M. Benner, Silvana Duran-Ortiz, Yanrong Qian, Edward O. List, Darlene E. Berryman, Jason K. Kim, and John J. Kopchick

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Methionine deprivation suppresses triple-negative breast cancer metastasis in vitro and in vivo, Hyein Jeon, Jae Hwan Kim, Eunjung Lee, Young Jin Jang, Joe Eun Son, Jung Yeon Kwon, Tae-Gyu Lim, Sunghoon Kim, Jung Han Yoon Park, Jong-Eun Kim, and Ki Won Lee

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Frontline Science: Splenic progenitors aid in maintaining high neutrophil numbers at sites of sterile chronic inflammation, Siddharth Jhunjhunwala, David Alvarez, Stephanie Aresta-DaSilva, Katherine Tang, Benjamin C. Tang, Dale Greiner, Peter E. Newburger, Ulrich H. von Andrian, Robert Langer, and Daniel G. Anderson

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ChREBP Regulates Fructose-induced Glucose Production Independently of Insulin Signaling, Mi-Sung Kim, Sarah A. Krawczyk, Ludivine Doridot, Alan J. Fowler, Jennifer X. Wang, Sunia A. Trauger, Hye Lim Noh, Hee Joon Kang, John K. Meissen, Matthew Blatnik, Jason K. Kim, Michelle Lai, and Mark A. Herman

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Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition), Daniel J. Klionsky, Roger J. Davis, Fen-Biao Gao, and Panagiotis D. Velentzas

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Raptor/mTORC1 loss in adipocytes causes progressive lipodystrophy and fatty liver disease, Peter L. Lee, Yuefeng Tang, Huawei Li, and David A. Guertin

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Transcriptional activation of follistatin by Nrf2 protects pulmonary epithelial cells against silica nanoparticle-induced oxidative stress, Chen Lin, Xinyuan Zhao, Desen Sun, Lingda Zhang, Wenpan Fang, Tingjia Zhu, Qiang Wang, Botao Liu, Saisai Wei, Guangdi Chen, Zhengping Xu, and Xiangwei Gao

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Activation of mTORC1 is essential for beta-adrenergic stimulation of adipose browning, Dianxin Liu, Marica Bordicchia, Chaoying Zhang, Huafeng Fang, Wan Wei, Jian-Liang Li, Adilson L. Guilherme, Kalyani V. P. Guntur, Michael P. Czech, and Sheila Collins

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Tead and AP1 Coordinate Transcription and Motility, Xiangfan Liu, Huapeng Li, Mihir S. Rajurkar, Qi Li, Jennifer L. Cotton, Jianhong Ou, Lihua J. Zhu, Hira L. Goel, Arthur M. Mercurio, Joo-Seop Park, Roger J. Davis, and Junhao Mao

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DNAH6 and Its Interactions with PCD Genes in Heterotaxy and Primary Ciliary Dyskinesia, You Li, Hisato Yagi, Gregory M. Hendricks, Gregory J. Pazour, and Cecilia W. Lo

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Closing the net on retroviruses, Jeremy Luban

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alphavbeta6 Integrin Promotes Castrate-Resistant Prostate Cancer through JNK1-Mediated Activation of Androgen Receptor, Huimin Lu, Tao Wang, Zhong Jiang, Roger J. Davis, Thomas J. Fitzgerald, and Lucia R. Languino

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Early Combination Antiretroviral Therapy Limits Exposure to HIV-1 Replication and Cell-Associated HIV-1 DNA Levels in Infants, Margaret M. McManus, Eric O. Mick, Richard W. Hudson Jr., Lynne M. Mofenson, John L. Sullivan, Mohan Somasundaran, Katherine Luzuriaga, and PACTG 356 Investigators

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The Origin of Human White, Brown, and Brite/Beige Adipocytes, So Yun Min

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Human 'brite/beige' adipocytes develop from capillary networks, and their implantation improves metabolic homeostasis in mice, So Yun Min, Jamie Kady, Minwoo Nam, Raziel Rojas-Rodriguez, Aaron Berkenwald, Jong Hun Kim, Hye Lim Noh, Jason K. Kim, Marcus P. Cooper, Timothy P. Fitzgibbons, Michael A. Brehm, and Silvia Corvera

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Cellular perception and misperception: Internal models for decision-making shaped by evolutionary experience, Amir Mitchell and Wendell Lim (BioEssays : news and reviews in molecular, cellular and developmental biology)

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Malaria - how this parasitic infection aids and abets EBV-associated Burkitt lymphomagenesis, Ann M. Moormann and Jeffrey A. Bailey

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Distinct Differences on Neointima Formation in Immunodeficient and Humanized Mice after Carotid or Femoral Arterial Injury, Jill Moser, Joris van Ark, Marcory C. van Dijk, Dale L. Greiner, Leonard D. Shultz, Harry van Goor, and Jan-Luuk Hillebrands

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CPEB1 mediates epithelial-to-mesenchyme transition and breast cancer metastasis, Kentaro Nagaoka, K. Fujii, H. Zhang, K. Usuda, G. Watanabe, Maria Ivshina, and Joel D. Richter

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A novel ICK mutation causes ciliary disruption and lethal endocrine-cerebro-osteodysplasia syndrome, Machteld M. Oud, Gregory J. Pazour, Bruno Reversade, and Heleen H. Arts

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Suppression of ischemia in arterial occlusive disease by JNK-promoted native collateral artery development, Kasmir Ramo, Koichi Sugamura, Siobhan M. Craige, John F. Keaney Jr., and Roger J. Davis

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Staufen Negatively Modulates microRNA Activity in Caenorhabditis elegans, Zhiji Ren, Isana Veksler-Lublinsky, David Morrissey, and Victor R. Ambros

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Impact of Plasmodium falciparum Coinfection on Longitudinal Epstein-Barr Virus Kinetics in Kenyan Children, Arnold Reynaldi, Timothy E. Schlub, Kiprotich Chelimo, Peter Odada Sumba, Erwan Piriou, Sidney Ogolla, Ann M. Moormann, Rosemary A. Rochford, and Miles P. Davenport

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Protein Kinase Mitogen-activated Protein Kinase Kinase Kinase Kinase 4 (MAP4K4) Promotes Obesity-induced Hyperinsulinemia, Rachel J. Roth Flach, Laura V. Danai, Marina DiStefano, Mark Kelly, Lorena Garcia Menendez, Agata Jurczyk, Rohit B. Sharma, Dae Young Jung, Jong Hun Kim, Jason K. Kim, Rita Bortell, Laura C. Alonso, and Michael P. Czech

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Endothelial Mitogen-Activated Protein Kinase Kinase Kinase Kinase 4 Is Critical for Lymphatic Vascular Development and Function, Rachel J. Roth Flach, Chang-An Guo, Laura V. Danai, Joseph C. Yawe, Sharvari Gujja, Yvonne J.K. Edwards, and Michael P. Czech

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Genetic link between renal birth defects and congenital heart disease, Jovenal T. San Agustin, Nikolai Klena, Kristi Granath, Ashok Panigrahy, Eileen Stewart, William Devine, Lara Strittmatter, Julie A. Jonassen, Xiaoqin Liu, Cecilia W. Lo, and Gregory J. Pazour

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Emerging Complexities in Adipocyte Origins and Identity, Joan Sanchez-Gurmaches, Chien-Min Hung, and David A. Guertin

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beta1 integrin- and JNK-dependent tumor growth upon hypofractionated radiation, Aejaz Sayeed, Huimin Lu, Qin Liu, David Deming Ii, Alexander Duffy, Peter McCue, Adam P. Dicker, Roger J. Davis, Dmitry Gabrilovich, Ulrich Rodeck, Dario C. Altieri, and Lucia R. Languino

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Tenomodulin promotes human adipocyte differentiation and beneficial visceral adipose tissue expansion, Ozlem Senol-Cosar, Rachel J. Roth Flach, Marina DiStefano, Anil K. Chawla, Sarah M. Nicoloro, Juerg R. Straubhaar, Olga T. Hardy, Hye Lim Noh, Jason K. Kim, Martin Wabitsch, Philipp E. Scherer, and Michael P. Czech

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Association between First Trimester Pregnancy Associated Plasma Protein–A (PAPP-A) and Gestational Diabetes Mellitus Development, Aylin Sert, Katherine Leung, Molly E. Waring, Raziel Rojas-Rodriguez, Silvia Corvera, and Tiffany A. Moore Simas

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Biogenesis and function of tRNA fragments during sperm maturation and fertilization in mammals, Upasna Sharma, Colin C. Conine, Jeremy Shea, Ana Boskovic, Alan G. Derr, Xin Y. Bing, Clemence Belleannee, Alper Kucukural, Ryan W. Serra, Fengyun Sun, Lina Song, Benjamin R. Carone, Emiliano P. Ricci, Xin Z. Li, Lucas Fauquier, Melissa J. Moore, Robert Sullivan, Craig C. Mello, Manuel Garber, and Oliver J. Rando

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Impaired neurodevelopment by the low complexity domain of CPEB4 reveals a convergent pathway with neurodegeneration, Jihae Shin, Johnny S. Salameh, and Joel D. Richter

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Cholesterol-Independent SREBP-1 Maturation Is Linked to ARF1 Inactivation, Lorissa J. Smulan, Wei Ding, Elizaveta Freinkman, Sharvari Gujja, Yvonne J. Edwards K, and Amy K. Walker

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The RNase PARN-1 Trims piRNA 3' Ends to Promote Transcriptome Surveillance in C. elegans, Wen Tang, Shikui Tu, Heng-Chi Lee, Zhiping Weng, and Craig C. Mello

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Adipose tissue mTORC2 regulates ChREBP-driven de novo lipogenesis and hepatic glucose metabolism, Yuefeng Tang, Martina Wallace, Joan Sanchez-Gurmaches, Wen-Yu Hsiao, Huawei Li, Peter L. Lee, Santiago Vernia, Christian M. Metallo, and David A. Guertin

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Comparison of RNA isolation and associated methods for extracellular RNA detection by high-throughput quantitative polymerase chain reaction, Kahraman Tanriverdi, Alper Kucukural, Ekaterina Mikhalev, Selim E. Tanriverdi, Rosalind Lee, Victor R. Ambros, and Jane Freedman

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Inactivation of nuclear GSK3beta by Ser(389) phosphorylation promotes lymphocyte fitness during DNA double-strand break response, Tina M. Thornton, Pilar Delgado, Liang Chen, Beatriz Salas, Dimitry Krementsov, Miriam Fernandez, Santiago Vernia, Roger J. Davis, Ruth Heimann, Cory Teuscher, Michael S. Krangel, Almudena R. Ramiro, and Mercedes Rincon

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Fibroblast Growth Factor 21 Mediates Glycemic Regulation by Hepatic JNK, Santiago Vernia, Julie Cavanagh-Kyros, Tamera Barrett, Cathy Tournier, and Roger J. Davis

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An alternative splicing program promotes adipose tissue thermogenesis, Santiago Vernia, Yvonne J. K. Edwards, Myoung Souk Han, Julie Cavanagh-Kyros, Tamera Barrett, Jason K. Kim, and Roger J. Davis

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Excitatory transmission onto AgRP neurons is regulated by cJun NH2-terminal kinase 3 in response to metabolic stress, Santiago Vernia, Caroline Morel, Joseph C. Madara, Julie Cavanagh-Kyros, Tamera Barrett, Kathryn O. Chase, Norman J. Kennedy, Dae Young Jung, Jason K. Kim, Neil Aronin, Richard A. Flavell, Bradford B. Lowell, and Roger J. Davis

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Human basal body basics, Anastassiia Vertii, Hui-Fang Hung, Heidi Hehnly, and Stephen J. Doxsey

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Map4k4 Signaling Nodes in Metabolic and Cardiovascular Diseases, Joseph V. Virbasius and Michael P. Czech

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Metagenomic Sequencing with Strain-Level Resolution Implicates Uropathogenic E. coli in Necrotizing Enterocolitis and Mortality in Preterm Infants, Doyle V. Ward, Matthias Scholz, Moreno Zolfo, Diana H. Taft, Kurt R. Schibler, Adrian Tett, Nicola Segata, and Ardythe L. Morrow

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Metabolic network rewiring of propionate flux compensates vitamin B12 deficiency in C. elegans, Emma Watson, Viridiana Olin-Sandoval, Michael J. Hoy, Chi-Hua Li, Timo Louisse, Victoria Yao, Akihiro Mori, Amy D. Holdorf, Olga G. Troyanskaya, Markus Ralser, and Albertha J. M. Walhout

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Multisite phosphorylation by MAPK, Alan J. Whitmarsh and Roger J. Davis

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Macrophages Are Regulators of Whole Body Metabolism: A Dissertation, Joseph C. Yawe

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A Caenorhabditis elegans Genome-Scale Metabolic Network Model, L. Safak Yilmaz and Albertha J. M. Walhout (Cell systems)

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RNA polymerase II depletion promotes transcription of alternative mRNA species, Lijian Yu, Mayuri Rege, Craig L. Peterson, and Michael R. Volkert

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The molecular basis of the genesis of basal tone in internal anal sphincter, Cheng-Hai Zhang, Donghai Lui, Ping Lu, Kaizhi Zheng, Siobhan M. Craige, Lawrence Lifshitz, John F. Keaney Jr., Kevin E. Fogarty, Ronghua Zhuge, and Min-Sheng Zhu

Publications from 2015

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The p53R172H Mutant Does Not Enhance Hepatocellular Carcinoma Development and Progression, Leanne G. Ahronian, David R. Driscoll, David S. Klimstra, and Brian C. Lewis

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Biodistribution and function of extracellular miRNA-155 in mice, Shashi Bala, Timea Csak, Fatemeh Momen-Heravi, Dora Lippai, Karen Kodys, Donna Catalano, Abhishek Satishchandran, Victor R. Ambros, and Gyongyi Szabo

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Uncoupling lifespan and healthspan in Caenorhabditis elegans longevity mutants, Ankita Bansal, Lihua Julie Zhu, Kelvin Yen, and Heidi A. Tissenbaum

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SWI/SNF recruitment to a DNA double-strand break by the NuA4 and Gcn5 histone acetyltransferases, Gwendolyn M. Bennett and Craig L. Peterson

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Novel Observations From Next-Generation RNA Sequencing of Highly Purified Human Adult and Fetal Islet Cell Subsets, David M. Blodgett, Anetta Nowosielska, Shaked Afik, Susanne Pechhold, Anthony J. Cura, Norman J. Kennedy, Soyoung Kim, Alper Kucukural, Roger J. Davis, Sally C. Kent, Dale L. Greiner, Manuel Garber, David M. Harlan, and Philip J. diLorio Jr.

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The ssDNA Mutator APOBEC3A Is Regulated by Cooperative Dimerization, Markus-Frederik Bohn, Shivender Shandilya, Tania V. Silvas, Ellen A. Nalivaika, Takahide Kouno, Brian Kelch, Sean P. Ryder, Nese Kurt Yilmaz, Mohan Somasundaran, and Celia A. Schiffer

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DNA-binding-domain fusions enhance the targeting range and precision of Cas9, Mehmet Fatih Bolukbasi, Ankit Gupta, Sarah Oikemus, Alan G. Derr, Manuel Garber, Michael H. Brodsky, Lihua Julie Zhu, and Scot A. Wolfe

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Robust Distal Tip Cell Pathfinding in the Face of Temperature Stress Is Ensured by Two Conserved microRNAS in Caenorhabditis elegans, Samantha L. Burke, Molly Hammell, and Victor R. Ambros

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A laminin 511 matrix is regulated by TAZ and functions as the ligand for the alpha6Bbeta1 integrin to sustain breast cancer stem cells, Cheng Chang, Hira Lal Goel, Huijie Gao, Bryan M. Pursell, Leonard D. Shultz, Dale L. Greiner, Sulev Ingerpuu, Manuel Patarroyo, Shiliang Cao, Elgene Lim, Junhao Mao, Karen Kulju. McKee, Peter D. Yurchenco, and Arthur M. Mercurio

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Alternatively Activated M2 Macrophages Improve Autologous Fat Graft Survival in a Mouse Model through Induction of Angiogenesis, Ava Chappell, Jorge Lujan-Hernandez, Dylan Perry, Silvia Corvera, and Janice F. Lalikos

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R loops regulate promoter-proximal chromatin architecture and cellular differentiation, Poshen B. Chen, Hsiuyi V. Chen, Diwash Acharya, Oliver J. Rando, and Thomas G. Fazzio

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RNA Interference in Caenorhabditis elegans, Darryl Conte Jr., Lesley T. MacNeil, Albertha J. M. Walhout, and Craig C. Mello (Current protocols in molecular biology / edited by Frederick M. Ausubel ... [et al.])

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Haematopoietic cell-derived Jnk1 is crucial for chronic inflammation and carcinogenesis in an experimental model of liver injury, Francisco Javier Cubero, Gang Zhao, Yulia A. Nevzorova, Maximilian Hatting, Malika Al Masaoudi, Julien Verdier, Jin Peng, Frederik M. Schaefer, Nadine Hermanns, Mark V. Boekschoten, Christoph Grouls, Nikolaus Gassler, Fabian Kiessling, Michael Muller, Roger J. Davis, Christian Liedtke, and Christian Trautwein

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Novel Jbts17 mutant mouse model of Joubert syndrome with cilia transition zone defects and cerebellar and other ciliopathy related anomalies, Rama Rao Damerla, Cheng Cui, George C. Gabriel, Xiaoqin Liu, Branch Craige, Brian C. Gibbs, Richard Francis, You Li, Bishwanath Chatterjee, Jovenal T. San Agustin, Thibaut Eguether, Ramiah Subramanian, George B. Witman, Jacques L. Michaud, Gregory J. Pazour, and Cecilia W. Lo (Human molecular genetics)

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Inducible Deletion of Protein Kinase Map4k4 in Obese Mice Improves Insulin Sensitivity in Liver and Adipose Tissues, Laura V. Danai, Rachel J. Roth Flach, Joseph V Virbasius, Lorena Garcia Menendez, Dae Young Jung, Jong Hun Kim, Jason K. Kim, and Michael P. Czech

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Plasmodium falciparum Protein Microarray Antibody Profiles Correlate With Protection From Symptomatic Malaria in Kenya, Arlene E. Dent, Rie Nakajima, Li Liang, Elisabeth Baum, Ann M. Moormann, Peter Odada Sumba, John Vulule, Denise Babineau, Arlo Randall, D. Huw Davies, Philip L. Felgner, and James W. Kazura

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s-Adenosylmethionine Levels Govern Innate Immunity through Distinct Methylation-Dependent Pathways, Wei Ding, Lorissa J. Smulan, Nicole S. Hou, Stefan Taubert, Jennifer L. Watts, and Amy K. Walker

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The Lipid Droplet Protein Hypoxia-inducible Gene 2 Promotes Hepatic Triglyceride Deposition by Inhibiting Lipolysis, Marina T. DiStefano, Laura V. Danai, Rachel J. Roth Flach, Anil K. Chawla, David J. Pedersen, Adilson L. Guilherme, and Michael P. Czech