The Program in Molecular Medicine at the University of Massachusetts Medical School was established in a new research building in 1989. Faculty include both clinical investigators and basic scientists, many of whom focus their research on human disease processes. The laboratory groups and core facilities that compose Molecular Medicine represent many disciplines in the bio-medical sciences: biochemistry and molecular biology, cell biology, medicine, immunology, molecular genetics and microbiology, pediatrics, pharmacology, physiology, genomics, bioinformatics and proteomics. This diverse scientific environment makes the Program an exceptional training ground for graduate students and postdoctoral fellows, who in turn contribute much to its vitality and excitement. This collection showcases publications and presentations written by faculty and researchers of the Program in Molecular Medicine.

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Publications from 2015

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A laminin 511 matrix is regulated by TAZ and functions as the ligand for the alpha6Bbeta1 integrin to sustain breast cancer stem cells, Cheng Chang, Hira Lal Goel, Huijie Gao, Bryan M. Pursell, Leonard D. Shultz, Dale L. Greiner, Sulev Ingerpuu, Manuel Patarroyo, Shiliang Cao, Elgene Lim, Junhao Mao, Karen Kulju. McKee, Peter D. Yurchenco, and Arthur M. Mercurio

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RNA Interference in Caenorhabditis elegans, Darryl Conte Jr., Lesley T. MacNeil, Albertha J. M. Walhout, and Craig C. Mello

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Suppression of pervasive noncoding transcription in embryonic stem cells by esBAF, Sarah J. Hainer, Weifeng Gu, Benjamin R. Carone, Benjamin D. Landry, Oliver J. Rando, Craig C. Mello, and Thomas G. Fazzio

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Control of stem cell self-renewal and differentiation by the heterochronic genes and the cellular asymmetry machinery in Caenorhabditis elegans, Omid F. Harandi and Victor R. Ambros

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Research resource: Monitoring endoplasmic reticulum membrane integrity in beta-cells at the single-cell level, Kohsuke Kanekura, Jianhong Ou, Takashi Hara, Lihua (Julie) Zhu, and Fumihiko Urano

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Prostate Tumorigenesis Induced by PTEN Deletion Involves Estrogen Receptor beta Repression, Paul Mak, Jianrong Li, Sanjoy Samanta, Cheng Chang, D. Joseph Jerry, Roger J. Davis, Irwin Leav, and Arthur M. Mercurio

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Precision cancer mouse models through genome editing with CRISPR-Cas9, Haiwei Mou, Zachary Kennedy, Daniel G. Anderson, Hao Yin, and Wen Xue

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Effect of transmission intensity and age on subclass antibody responses to Plasmodium falciparum pre-erythrocytic and blood-stage antigens, Gregory S. Noland, Paul Jansen, John M. Vulule, Gregory S. Park, Bartholomew N. Ondigo, James W. Kazura, Ann M. Moormann, and Chandy C. John

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An efficient and sensitive method for preparing cDNA libraries from scarce biological samples, Catherine H. Sterling, Isana Veksler-Lublinsky, and Victor R. Ambros

Publications from 2014

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NPHP4 controls ciliary trafficking of membrane proteins and large soluble proteins at the transition zone, Junya Awata, Saeko Takada, Clive Standley, Karl-Ferdinand Lechtreck, Karl D. Bellve, Gregory J. Pazour, Kevin E. Fogarty, and George B. Witman

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Transcriptional regulation of Caenorhabditis elegans FOXO/DAF-16 modulates lifespan, Ankita Bansal, Eun-Soo Kwon, Darryl Conte Jr., Haibo Liu, Michael J. Gilchrist, Lesley T. MacNeil, and Heidi A. Tissenbaum

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Gammaretroviral pol sequences act in cis to direct polysome loading and NXF1/NXT-dependent protein production by gag-encoded RNA, Hanni Bartels and Jeremy Luban

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Genetic and pharmacological reactivation of the mammalian inactive X chromosome, Sanchita Bhatnagar, Xiaochun Zhu, Jianhong Ou, Ling Lin, Lynn Chamberlain, Lihua Julie Zhu, Narendra Wajapeyee, and Michael R. Green

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PSF contacts exon 7 of SMN2 pre-mRNA to promote exon 7 inclusion, Sunghee Cho, Heegyum Moon, Tiing Jen Loh, Hyun Kyung Oh, Darren Reese Williams, D. Joshua Liao, Jianhua Zhou, Michael R. Green, Xuexiu Zheng, and Haihong Shen

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Adipose tissue angiogenesis: impact on obesity and type-2 diabetes, Silvia Corvera and Olga Gaelekman

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Distinct functions for IFT140 and IFT20 in opsin transport, Jacquelin A. Crouse, Vanda S. Lopes, Jovenal T. San Agustin, Brian T. Keady, David S. Williams, and Gregory J. Pazour

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Cyclophilin A promotes HIV-1 reverse transcription but its effect on transduction correlates best with its effect on nuclear entry of viral cDNA, Alberto De Iaco and Jeremy Luban

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Differentiation between temporary and real non-clearability of biotinylated IgG antibody by avidin in mice, Shuping Dou, John Virostko, Mary Rusckowski, Dale L. Greiner, Alvin C. Powers, and Guozheng Liu

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Comparison between two labeled agents in mice using a coinjection-ratio approach in contrast to a conventional group approach, Shuping Dou, Yuzhen Wang, Bruce A. Barton, Ling Chen, Mary Rusckowski, Leonard D. Shultz, Dale L. Greiner, and Guozheng Liu

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The BRAF oncoprotein functions through the transcriptional repressor MAFG to mediate the CpG Island Methylator phenotype, Minggang Fang, Jianhong Ou, Lloyd Hutchinson, and Michael R. Green

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Arf4 is required for Mammalian development but dispensable for ciliary assembly, John A. Follit, Jovenal T. San Agustin, Julie A. Jonassen, Tingting Huang, Jaime A. Rivera-Perez, Kimberly D. Tremblay, and Gregory J. Pazour

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Transcription factor binding to Caenorhabditis elegans first introns reveals lack of redundancy with gene promoters, Juan I. Fuxman Bass, Alex M. Tamburino, Akihiro Mori, Nathan Beittel, Matthew T. Weirauch, John S. Reece-Hoyes, and Albertha J. M. Walhout

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A single vertebrate DNA virus protein disarms invertebrate immunity to RNA virus infection, Don B. Gammon, Sophie Duraffour, Daniel K. Rozelle, Heidi Hehnly, Rita Sharma, Michael E. Sparks, Cara C. West, Ying Chen, James J. Moresco, Graciela Andrei, John H. Connor, Darryl Conte Jr., Dawn E. Gundersen-Rindal, William L. Marshall, John R. Yates, Neal S. Silverman, and Craig C. Mello

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Regulated splicing of the alpha6 integrin cytoplasmic domain determines the fate of breast cancer stem cells, Hira Lal Goel, Tatiana Gritsko, Bryan Pursell, Cheng Chang, Leonard D. Shultz, Dale L. Greiner, Jens Henrik Norum, Rune Toftgard, Leslie M. Shaw, and Arthur M. Mercurio

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Synergistic tumor suppression by combined inhibition of telomerase and CDKN1A, Romi Gupta, Yuying Dong, Peter D. Solomon, Hiromi I. Wettersten, Christopher J. Cheng, JIn-Na Min, Jeremy Henson, Shaillay Kumar Dogra, Sung H. Hwang, Bruce D. Hammock, Lihua Julie Zhu, Roger R. Reddel, W. Mark Saltzman, Robert H. Weiss, Sandy Chang, Michael R. Green, and Narendra Wajapeyee

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Rab11 endosomes contribute to mitotic spindle organization and orientation, Heidi Hehnly and Stephen J. Doxsey

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The machinery at endoplasmic reticulum-plasma membrane contact sites contributes to spatial regulation of multiple Legionella effector proteins, Andree Hubber, Kohei Arasaki, Fubito Nakatsu, Camille Hardiman, David G. Lambright, Pietro De Camilli, Hiroki Nagai, and Craig R. Roy

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Rictor/mTORC2 Loss in the Myf5 Lineage Reprograms Brown Fat Metabolism and Protects Mice against Obesity and Metabolic Disease, Chien-Min Hung, Camila Martinez Calejman, Joan Sanchez-Gurmaches, Huawei Li, Clary B. Clish, Simone Hettmer, Amy J. Wagers, and David A. Guertin

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Exon 9 skipping of apoptotic caspase-2 pre-mRNA is promoted by SRSF3 through interaction with exon 8, Ha Na Jang, Minho Lee, Tiing Jen Loh, Seung-Woo Choi, Hyun Kyung Oh, Heegyum Moon, Sunghee Cho, Seong-Eui Hong, Do Han Kim, Zhi Sheng, Michael R. Green, Daeho Park, Xuexiu Zheng, and Haihong Shen

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A population of Langerin-positive dendritic cells in murine Peyer's patches involved in sampling beta-glucan microparticles, Magdia De Jesus, Gary R. Ostroff, Stuart M. Levitz, Toni R. Bartling, and Nicholas J. Mantis

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Cas9 effector-mediated regulation of transcription and differentiation in human pluripotent stem cells, Nicola A. Kearns, Ryan M. J. Genga, Metewo Selase Enuameh, Manuel Garber, Scot A. Wolfe, and Rene Maehr

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Blockade of the programmed death-1 (PD1) pathway undermines potent genetic protection from type 1 diabetes, Nora M. Kochupurakkal, Annie J. Kruger, Sudipta Tripathi, Bing Zhu, La Tonya Adams, Daniel B. Rainbow, Aldo A. Rossini, Dale L. Greiner, Mohamed H. Sayegh, Linda S. Wicker, and Indira Guleria

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Regulation of a transcription factor network by Cdk1 coordinates late cell cycle gene expression, Benjamin D. Landry, Claudine E. Mapa, Heather E. Arsenault, Kristin E. Poti, and Jennifer A. Benanti

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A Large-Scale RNAi-Based Mouse Tumorigenesis Screen Identifies New Lung Cancer Tumor Suppressors that Repress FGFR Signaling, Ling Lin, Lynn Chamberlain, Magnolia L. Pak, Arvindhan Nagarajan, Romi Gupta, Lihua Julie Zhu, Casey M. Wright, Kwun M. Fong, Narendra Wajapeyee, and Michael R. Green

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Cancer-Relevant Splicing Factor CAPERalpha Engages the Essential Splicing Factor SF3b155 in a Specific Ternary Complex, Sarah Loerch, Alexandre Maucuer, Valerie Manceau, Michael R. Green, and Clara L. Kielkopf

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A therapeutically targetable mechanism of BCR-ABL-independent imatinib resistance in chronic myeloid leukemia, Leyuan Ma, Yi Shan, Robert Bai, Liting Xue, Christopher A. Eide, Jianhong Ou, Lihua Julie Zhu, Lloyd Hutchinson, Jan Cerny, Hanna Jean Khoury, Zhi Sheng, Brian J. Druker, Shaoguang Li, and Michael R. Green

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The embryonic mir-35 family of microRNAs promotes multiple aspects of fecundity in Caenorhabditis elegans, Katherine McJunkin and Victor R. Ambros

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SRSF2 promotes splicing and transcription of exon 11 included isoform in Ron proto-oncogene, Heegyum Moon, Sunghee Cho, Tiing Jen Loh, Hyun Kyung Oh, Ha Na Jang, Jianhua Zhou, Young-Soo Kwon, D. Joshua Liao, Youngsoo Jun, Soohyun Eom, Claudia Ghigna, Giuseppe Biamonti, Michael R. Green, Xuexiu Zheng, and Haihong Shen

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The hunt for protective correlates of immunity to Plasmodium falciparum malaria, Ann M. Moormann and V. Ann Stewart

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IL-1 signaling in obesity-induced hepatic lipogenesis and steatosis, Kimberly A. Negrin, Rachel J. Roth Flach, Marina T. DiStefano, Anouch Matevossian, Randall H. Friedline, Dae Young Jung, Jason K. Kim, and Michael P. Czech

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miR-14 Regulates Autophagy during Developmental Cell Death by Targeting ip3-kinase 2, Charles Nelson, Victor R. Ambros, and Eric H. Baehrecke

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MicroRNA-378 controls classical brown fat expansion to counteract obesity, Dongning Pan, Chunxiao Mao, Brian Quattrochi, Randall H. Friedline, Lihua Julie Zhu, Dae Young Jung, Jason K. Kim, Brian C. Lewis, and Yong-Xu Wang

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Diversity and expression of microRNAs in the filarial parasite, Brugia malayi, Catherine B. Poole, Weifeng Gu, Sanjay Kumar, Jingmin Jin, Paul J. Davis, David Bauche, and Larry A. McReynolds

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Drosophila Sirt2/mammalian SIRT3 deacetylates ATP synthase beta and regulates complex V activity, Motiur Rahman, Niraj K. Nirala, Alka Singh, Lihua Julie Zhu, Kaori Taguchi, Takeshi Bamba, Eiichiro Fukusaki, Leslie M. Shaw, David G. Lambright, Jairaj K. Acharya, and Usha R. Acharya

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Vpx rescue of HIV-1 from the antiviral state in mature dendritic cells is independent of the intracellular deoxynucleotide concentration, Christian Reinhard, Dario Bottinelli, Baek Kim, and Jeremy Luban

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Epstein-barr virus latent membrane protein 1 genetic variability in peripheral blood B cells and oropharyngeal fluids, Nicholas Renzette, Mohan Somasundaran, Frank E. Brewster, James Coderre, Eric R. Weiss, Margaret M. McManus, Thomas C. Greenough, Barbara Tabak, Manuel Garber, Timothy F. Kowalik, and Katherine Ruiz De Luzuriaga

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Adipocyte lineages: tracing back the origins of fat, Joan Sanchez-Gurmaches and David A. Guertin

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A KRAS-directed transcriptional silencing pathway that mediates the CpG island methylator phenotype, Ryan W. Serra, Minggang Fang, Sung Mi Park, Lloyd Hutchinson, and Michael R. Green

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RLIM is dispensable for X-chromosome inactivation in the mouse embryonic epiblast, JongDae Shin, Mary C. Wallingford, Judith Gallant, Chelsea Marcho, Baowei Jiao, Meg Byron, Michael Bossenz, Jeanne B. Lawrence, Stephen N. Jones, Jesse Mager, and Ingolf Bach

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A separable domain of the p150 subunit of human Chromatin Assembly Factor-1 promotes protein and chromosome associations with nucleoli, Corey L. Smith, Timothy D. Matheson, Daniel J. Trombly, Xiaoming Sun, Eric Campeau, Xuemei Han, John R. Yates III, and Paul D. Kaufman

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Single point mutation in Rabenosyn-5 in a female with intractable seizures and evidence of defective endocytotic trafficking, Sylvia Stockler, Silvia Corvera, David G. Lambright, Kevin E. Fogarty, Ekaterina Nosova, Deborah Marie Leonard, Robert Steinfeld, Cameron Ackerley, Casper Shyr, Nicolas Au, Kathrin Selby, Margot van Allen, Hilary Vallance, Ron Wevers, David Watkins, David Rosenblatt, Colin J. Ross, Elizabeth Conibear, Wyeth Wasserman, and Clara van Karnebeek

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The Nef-like effect of murine leukemia virus glycosylated gag on HIV-1 infectivity is mediated by its cytoplasmic domain and depends on the AP-2 adaptor complex, Yoshiko Usami, Sergei Popov, and Heinrich G. Gottlinger

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Resistance to vemurafenib resulting from a novel mutation in the BRAFV600E kinase domain, Timothy R. Wagenaar, Leyuan Ma, Benjamin P. Roscoe, Sung Mi Park, Daniel N. Bolon, and Michael R. Green

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Genetic adaptation to diet preserves longevity, Albertha J. M. Walhout

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Circulating microRNA profiles in human patients with acetaminophen hepatotoxicity or ischemic hepatitis, Jeanine Ward, Chitra Kanchagar, Isana Veksler-Lublinsky, Rosalind C. Lee, Mitchell R. McGill, Hartmut Jaeschke, Steven C. Curry, and Victor R. Ambros

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Evolutionary dynamics and tissue specificity of human long noncoding RNAs in six mammals, Stefan Washietl, Manolis Kellis, and Manuel Garber

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Interspecies Systems Biology Uncovers Metabolites Affecting C. elegans Gene Expression and Life History Traits, Emma Watson, Lesley T. MacNeil, Ashlyn D. Ritter, L. Safak Yilmaz, Adam P. Rosebrock, Amy A. Caudy, and Albertha J. M. Walhout

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Caenorhabditis elegans metabolic gene regulatory networks govern the cellular economy, Emma Watson and Albertha J. M. Walhout

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Determination and inference of eukaryotic transcription factor sequence specificity, Matthew T. Weirauch, Ally Yang, Mihai Albu, Atina G. Cote, Alejandro Montenegro-Montero, Philipp Drewe, Hamed S. Najafabadi, Samuel A. Lambert, Ishminder Mann, Kate Cook, Hong Zheng, Alejandra Goity, Harm van Bakel, Jean-Claude Lozano, Mary Galli, Mathew G. Lewsey, Eryong Huang, Tuhin Mukherjee, Xiaoting Chen, John S. Reece-Hoyes, Sridhar Govindarajan, Gad Shaulsky, Albertha J. M. Walhout, Francois-Yves Bouget, Gunnar Ratsch, Luis F. Larrondo, Joseph R. Ecker, and Timothy R. Hughes

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Worms, bacteria, and micronutrients: an elegant model of our diet, L. Safak Yilmaz and Albertha J. M. Walhout

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CRISPRseek: A Bioconductor Package to Identify Target-Specific Guide RNAs for CRISPR-Cas9 Genome-Editing Systems, Lihua Julie Zhu, Benjamin R. Holmes, Neil Aronin, and Michael H. Brodsky

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Mutations in conserved residues of the C. elegans microRNA Argonaute ALG-1 identify separable functions in ALG-1 miRISC loading and target repression, Anna Y. Zinovyeva, Samir Bouasker, Martin J. Simard, Christopher M. Hammell, and Victor R. Ambros

Publications from 2013

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Nucleosome dynamics regulates DNA processing, Nicholas L. Adkins, Hengyao Niu, Patrick Sung, and Craig L. Peterson

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Victor Ambros: the broad scope of microRNAs. Interview by Caitlin Sedwick, Victor R. Ambros

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Gene silencing in adipose tissue macrophages regulates whole-body metabolism in obese mice, Myriam Aouadi, Michaela Tencerova, Pranitha Vangala, Joseph Yawe, Sarah M. Nicoloro, Shinya U. Amano, Jessica L. Cohen, and Michael P. Czech

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The decapping scavenger enzyme DCS-1 controls microRNA levels in Caenorhabditis elegans, Gabriel D. Bosse, Stefan Ruegger, Maria C. Ow, Alejandro Vasquez-Rifo, Evelyne L. Rondeau, Victor R. Ambros, Helge Grosshans, and Martin J. Simard

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Humanized mice for the study of infectious diseases, Michael A. Brehm, Nathalie Jouvet, Dale L. Greiner, and Leonard D. Shultz

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Resurrecting remnants: the lives of post-mitotic midbodies, Chun-Ting Chen, Andreas W. Ettinger, Wieland B. Huttner, and Stephen J. Doxsey

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Gudu, an Armadillo repeat-containing protein, is required for spermatogenesis in Drosophila, Wei Cheng, Y. Tony Ip, and Zuoshang Xu

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Hdac6 regulates Tip60-p400 function in stem cells, Poshen B. Chen, Jui-Hung Hung, Taylor L. Hickman, Andrew H. Coles, James F. Carey, Zhiping Weng, Feixia Chu, and Thomas G. Fazzio

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p16 Stimulates CDC42-Dependent Migration of Hepatocellular Carcinoma Cells, Ya-Wen Chen, Hsiao-Chien Chu, Ze-Shiang Lin, Wei-Jyh Shiah, Chen-Pin Chou, David S. Klimstra, and Brian C. Lewis

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Novel strategies to enhance vaccine immunity against coccidioidomycosis, Garry T. Cole, Chiung-Yu Hung, Sam D. Sanderson, Brady J. Hurtgen, Marcel Wuthrich, Bruce S. Klein, George S. Deepe, Gary R. Ostroff, and Stuart M. Levitz

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Obesity Notches up fatty liver, Michael P. Czech

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Insulin signalling mechanisms for triacylglycerol storage, Michael P. Czech, Michaela Tencerova, David J. Pedersen, and Myriam Aouadi

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Translational control of cell growth and malignancy by the CPEBs, Andrea D'Ambrogio, Kentaro Nagaoka, and Joel D. Richter

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Map4k4 suppresses Srebp-1 and adipocyte lipogenesis independent of JNK signaling, Laura V. Danai, Adilson L. Guilherme, Kalyani V. P. Guntur, Juerg R. Straubhaar, Sarah M. Nicoloro, and Michael P. Czech

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TNPO3 protects HIV-1 replication from CPSF6-mediated capsid stabilization in the host cell cytoplasm, Alberto De Iaco, Federico A. Santoni, Anne Vannier, Michel Guipponi, Stylianos E. Antonarakis, and Jeremy Luban

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Global analysis of Drosophila Cys2-His2 zinc finger proteins reveals a multitude of novel recognition motifs and binding determinants, Metewo Selase Enuameh, Yuna Asriyan, Adam Richards, Ryan G. Christensen, Victoria L. Hall, Majid Kazemian, Cong Zhu, Hannah Pham, Qiong Cheng, Charles Blatti, Jessie A. Brasefield, Matthew D. Basciotta, Jianhong Ou, Joseph C. McNulty, Lihua Julie Zhu, Susan E. Celniker, Saurabh Sinha, Gary D. Stormo, Michael H. Brodsky, and Scot A. Wolfe

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Toward Understanding the Outer Membrane Uptake of Small Molecules by Pseudomonas aeruginosa, Elif Eren, Jamie Parkin, Ayodele Adelanwa, Belete R. Cheneke, Liviu Movileanu, Syma Khalid, and Bert Van den Berg

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MEN1 is a Melanoma Tumor Suppressor that Preserves Genomic Integrity by Stimulating Transcription of Genes that Promote Homologous Recombination-Directed DNA Repair, Minggang Fang, Fen Xia, Meera Mahalingam, Ching-Man A. Virbasius, Narendra Wajapeyee, and Michael R. Green

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Analysis of ciliary membrane protein dynamics using SNAP technology, John A. Follit and Gregory J. Pazour

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Using networks to measure similarity between genes: association index selection, Juan I. Fuxman Bass, Alos Diallo, Justin Nelson, Juan M. Soto, Chad L. Myers, and Albertha J. M. Walhout

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GLI1 regulates a novel neuropilin-2/alpha6beta1 integrin based autocrine pathway that contributes to breast cancer initiation, Hira Lal Goel, Bryan M. Pursell, Cheng Chang, Leslie M. Shaw, Junhao Mao, Karl Simin, Prashant Kumar, Craig W. Vander Kooi, Leonard D. Shultz, Dale L. Greiner, Jens Henrik Norum, Rune Toftgard, Charlotte Kuperwasser, and Arthur M. Mercurio

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beta1 integrins mediate resistance to ionizing radiation in vivo by inhibiting c-Jun amino terminal kinase1, Hira Lal Goel, Aejaz Sayeed, Michael Breen, Matthew J. Zarif, David S. Garlick, Irwin Leav, Roger J. Davis, Thomas J. Fitzgerald, Andea Morrione, Chung-Cheng Hsieh, Qin Liu, Adam P. Dicker, Dario C. Altieri, and Lucia R. Languino

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Targeted chromosomal deletions and inversions in zebrafish, Ankit Gupta, Victoria L. Hall, Fatma O. Kok, Masahiro Shin, Joseph C. McNulty, Nathan D. Lawson, and Scot A. Wolfe

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JNK expression by macrophages promotes obesity-induced insulin resistance and inflammation, Myoung Souk Han, Dae Young Jung, Caroline Morel, Saquib A. Lakhani, Jason K. Kim, Richard A. Flavell, and Roger J. Davis

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One among many: ODF2 isoform 9, a.k.a. Cenexin-1, is required for ciliogenesis, Heidi Hehnly, Hui-Fan Hung, and Stephen J. Doxsey

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Cardiac expression of human type 2 iodothyronine deiodinase increases glucose metabolism and protects against doxorubicin-induced cardiac dysfunction in male mice, Eun-Gyoung Hong, Brian W. Kim, Dae Young Jung, Jong Hun Kim, Tim Yu, Wagner Seixas Da Silva, Randall H. Friedline, Suzy D. Bianco, Stephen P. Seslar, Hiroko Wakimoto, Charles I. Berul, Kerry S. Russell, Ki Won Lee, P. Reed Larsen, Antonio C. Bianco, and Jason K. Kim

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Epigenetics in the human brain, Isaac B. Houston, Cyril J. Peter, Amanda C. Mitchell, Juerg R. Straubhaar, Evgeny I. Rogaev, and Schahram Akbarian

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Characterization and optimization of the glucan particle-based vaccine platform, Haibin Huang, Gary R. Ostroff, Chrono K. Lee, Charles A. Specht, and Stuart M. Levitz

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Inductive asymmetric cell division: The WRM leads the way, Takao Ishidate, Soyoung Kim, Craig C. Mello, and Masaki Shirayama

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U2AF65 adapts to diverse pre-mRNA splice sites through conformational selection of specific and promiscuous RNA recognition motifs, Jermaine L. Jenkins, Anant A. Agrawal, Ankit Gupta, Michael R. Green, and Clara L. Kielkopf

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Functional activity of RLIM/Rnf12 is regulated by phosphorylation-dependent nucleo-cytoplasmic shuttling, Baowei Jiao, Naoko Taniguchi-Ishigaki, Cenap Gungor, Marvin A. Peters, Ya-Wen Chen, Sabine Riethdorf, Alexander Drung, Leanne G. Ahronian, JongDae Shin, Rachna Pagnis, Klaus Pantel, Taro Tachibana, Brian C. Lewis, Steven A. Johnsen, and Ingolf Bach

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Activation of the Nlrp3 inflammasome in infiltrating macrophages by endocannabinoids mediates beta cell loss in type 2 diabetes, Tony Jourdan, Grzegorz Godlewski, Resat Cinar, Adeline Bertola, Gergo Szanda, Jie Liu, Joseph Tam, Tiffany Han, Bani Mukhopadhyay, Monica C. Skarulis, Cynthia Ju, Myriam Aouadi, Michael P. Czech, and George Kunos

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KLF15 is a molecular link between endoplasmic reticulum stress and insulin resistance, Dae Young Jung, UmaDevi Chalasani, Ning Pan, Randall H. Friedline, Domenick A. Prosdocimo, Minwoo Nam, Yoshihiro Azuma, Rajanikanth Maganti, Kristine Yu, Ashish Velagapudi, Bryan O'Sullivan-Murphy, Juliano L. Sartoretto, Mukesh K. Jain, Marcus P. Cooper, Fumihiko Urano, Jason K. Kim, and Susan Gray

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Role of the mixed-lineage protein kinase pathway in the metabolic stress response to obesity, Shashi Kant, Tamera Barrett, Anastassiia Vertii, Yun Hee Noh, Dae Young Jung, Jason K. Kim, and Roger J. Davis

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Widespread evidence of cooperative DNA binding by transcription factors in Drosophila development, Majid Kazemian, Hannah Pham, Scot A. Wolfe, Michael H. Brodsky, and Saurabh Sinha

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Generation of organized anterior foregut epithelia from pluripotent stem cells using small molecules, Nicola A. Kearns, Ryan M. J. Genga, Michael Ziller, Kristina Kapinas, Heiko Peters, Michael A. Brehm, Alexander Meissner, and Rene Maehr

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Wnt and CDK-1 regulate cortical release of WRM-1/beta-catenin to control cell division orientation in early Caenorhabditis elegans embryos, Soyoung Kim, Takao Ishidate, Rita Sharma, Martha C. Soto, Darryl Conte Jr., Craig C. Mello, and Masaki Shirayama

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Engrafted human cells generate adaptive immune responses to Mycobacterium bovis BCG infection in humanized mice, Jinhee Lee, Michael A. Brehm, Dale L. Greiner, Leonard D. Shultz, and Hardy Kornfeld