The Program in Molecular Medicine at the University of Massachusetts Medical School was established in a new research building in 1989. Faculty include both clinical investigators and basic scientists, many of whom focus their research on human disease processes. The laboratory groups and core facilities that compose Molecular Medicine represent many disciplines in the bio-medical sciences: biochemistry and molecular biology, cell biology, medicine, immunology, molecular genetics and microbiology, pediatrics, pharmacology, physiology, genomics, bioinformatics and proteomics. This diverse scientific environment makes the Program an exceptional training ground for graduate students and postdoctoral fellows, who in turn contribute much to its vitality and excitement. This collection showcases publications and presentations written by faculty and researchers of the Program in Molecular Medicine.

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Publications from 2014

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Distinct functions for IFT140 and IFT20 in opsin transport, Jacquelin A. Crouse, Vanda S. Lopes, Jovenal T. San Agustin, Brian T. Keady, David S. Williams, and Gregory J. Pazour

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Arf4 is required for Mammalian development but dispensable for ciliary assembly, John A. Follit, Jovenal T. San Agustin, Julie A. Jonassen, Tingting Huang, Jaime A. Rivera-Perez, Kimberly D. Tremblay, and Gregory J. Pazour

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Transcription factor binding to Caenorhabditis elegans first introns reveals lack of redundancy with gene promoters, Juan I. Fuxman Bass, Alex M. Tamburino, Akihiro Mori, Nathan Beittel, Matthew T. Weirauch, John S. Reece-Hoyes, and Albertha J. M. Walhout

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Rab11 endosomes contribute to mitotic spindle organization and orientation, Heidi Hehnly and Stephen J. Doxsey

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Cas9 effector-mediated regulation of transcription and differentiation in human pluripotent stem cells, Nicola A. Kearns, Ryan M. J. Genga, Metewo Selase Enuameh, Manuel Garber, Scot A. Wolfe, and Rene Maehr

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Vpx rescue of HIV-1 from the antiviral state in mature dendritic cells is independent of the intracellular deoxynucleotide concentration, Christian Reinhard, Dario Bottinelli, Baek Kim, and Jeremy Luban

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Epstein-barr virus latent membrane protein 1 genetic variability in peripheral blood B cells and oropharyngeal fluids, Nicholas Renzette, Mohan Somasundaran, Frank E. Brewster, James Coderre, Eric R. Weiss, Margaret M. McManus, Thomas C. Greenough, Barbara Tabak, Manuel Garber, Timothy F. Kowalik, and Katherine Ruiz De Luzuriaga

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A KRAS-directed transcriptional silencing pathway that mediates the CpG island methylator phenotype, Ryan W. Serra, Minggang Fang, Sung Mi Park, Lloyd Hutchinson, and Michael R. Green

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Genetic adaptation to diet preserves longevity, Albertha J. M. Walhout

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Interspecies Systems Biology Uncovers Metabolites Affecting C. elegans Gene Expression and Life History Traits, Emma Watson, Lesley T. MacNeil, Ashlyn D. Ritter, L. Safak Yilmaz, Adam P. Rosebrock, Amy A. Caudy, and Albertha J. M. Walhout

Publications from 2013

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Gene silencing in adipose tissue macrophages regulates whole-body metabolism in obese mice, Myriam Aouadi, Michaela Tencerova, Pranitha Vangala, Joseph Yawe, Sarah M. Nicoloro, Shinya U. Amano, Jessica L. Cohen, and Michael P. Czech

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Resurrecting remnants: the lives of post-mitotic midbodies, Chun-Ting Chen, Andreas W. Ettinger, Wieland B. Huttner, and Stephen J. Doxsey

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Gudu, an Armadillo repeat-containing protein, is required for spermatogenesis in Drosophila, Wei Cheng, Y. Tony Ip, and Zuoshang Xu

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Hdac6 regulates Tip60-p400 function in stem cells, Poshen B. Chen, Jui-Hung Hung, Taylor L. Hickman, Andrew H. Coles, James F. Carey, Zhiping Weng, Feixia Chu, and Thomas G. Fazzio

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p16 Stimulates CDC42-Dependent Migration of Hepatocellular Carcinoma Cells, Ya-Wen Chen, Hsiao-Chien Chu, Ze-Shiang Lin, Wei-Jyh Shiah, Chen-Pin Chou, David S. Klimstra, and Brian C. Lewis

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Insulin signalling mechanisms for triacylglycerol storage, Michael P. Czech, Michaela Tencerova, David J. Pedersen, and Myriam Aouadi

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Translational control of cell growth and malignancy by the CPEBs, Andrea D'Ambrogio, Kentaro Nagaoka, and Joel D. Richter

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TNPO3 protects HIV-1 replication from CPSF6-mediated capsid stabilization in the host cell cytoplasm, Alberto De Iaco, Federico A. Santoni, Anne Vannier, Michel Guipponi, Stylianos E. Antonarakis, and Jeremy Luban

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Global analysis of Drosophila Cys2-His2 zinc finger proteins reveals a multitude of novel recognition motifs and binding determinants, Metewo Selase Enuameh, Yuna Asriyan, Adam Richards, Ryan G. Christensen, Victoria L. Hall, Majid Kazemian, Cong Zhu, Hannah Pham, Qiong Cheng, Charles Blatti, Jessie A. Brasefield, Matthew D. Basciotta, Jianhong Ou, Joseph C. McNulty, Lihua Julie Zhu, Susan E. Celniker, Saurabh Sinha, Gary D. Stormo, Michael H. Brodsky, and Scot A. Wolfe

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Toward Understanding the Outer Membrane Uptake of Small Molecules by Pseudomonas aeruginosa, Elif Eren, Jamie Parkin, Ayodele Adelanwa, Belete R. Cheneke, Liviu Movileanu, Syma Khalid, and Bert Van den Berg

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MEN1 is a Melanoma Tumor Suppressor that Preserves Genomic Integrity by Stimulating Transcription of Genes that Promote Homologous Recombination-Directed DNA Repair, Minggang Fang, Fen Xia, Meera Mahalingam, Ching-Man A. Virbasius, Narendra Wajapeyee, and Michael R. Green

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Analysis of ciliary membrane protein dynamics using SNAP technology, John A. Follit and Gregory J. Pazour

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Using networks to measure similarity between genes: association index selection, Juan I. Fuxman Bass, Alos Diallo, Justin Nelson, Juan M. Soto, Chad L. Myers, and Albertha J. M. Walhout

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GLI1 regulates a novel neuropilin-2/alpha6beta1 integrin based autocrine pathway that contributes to breast cancer initiation, Hira Lal Goel, Bryan M. Pursell, Cheng Chang, Leslie M. Shaw, Junhao Mao, Karl Simin, Prashant Kumar, Craig W. Vander Kooi, Leonard D. Shultz, Dale L. Greiner, Jens Henrik Norum, Rune Toftgard, Charlotte Kuperwasser, and Arthur M. Mercurio

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beta1 integrins mediate resistance to ionizing radiation in vivo by inhibiting c-Jun amino terminal kinase1, Hira Lal Goel, Aejaz Sayeed, Michael Breen, Matthew J. Zarif, David S. Garlick, Irwin Leav, Roger J. Davis, Thomas J. Fitzgerald, Andea Morrione, Chung-Cheng Hsieh, Qin Liu, Adam P. Dicker, Dario C. Altieri, and Lucia R. Languino

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Targeted chromosomal deletions and inversions in zebrafish, Ankit Gupta, Victoria L. Hall, Fatma O. Kok, Masahiro Shin, Joseph C. McNulty, Nathan D. Lawson, and Scot A. Wolfe

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JNK expression by macrophages promotes obesity-induced insulin resistance and inflammation, Myoung Souk Han, Dae Young Jung, Caroline Morel, Saquib A. Lakhani, Jason K. Kim, Richard A. Flavell, and Roger J. Davis

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One among many: ODF2 isoform 9, a.k.a. Cenexin-1, is required for ciliogenesis, Heidi Hehnly, Hui-Fan Hung, and Stephen J. Doxsey

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Epigenetics in the human brain, Isaac B. Houston, Cyril J. Peter, Amanda C. Mitchell, Juerg R. Straubhaar, Evgeny I. Rogaev, and Schahram Akbarian

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U2AF65 adapts to diverse pre-mRNA splice sites through conformational selection of specific and promiscuous RNA recognition motifs, Jermaine L. Jenkins, Anant A. Agrawal, Ankit Gupta, Michael R. Green, and Clara L. Kielkopf

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Functional activity of RLIM/Rnf12 is regulated by phosphorylation-dependent nucleo-cytoplasmic shuttling, Baowei Jiao, Naoko Taniguchi-Ishigaki, Cenap Gungor, Marvin A. Peters, Ya-Wen Chen, Sabine Riethdorf, Alexander Drung, Leanne G. Ahronian, JongDae Shin, Rachna Pagnis, Klaus Pantel, Taro Tachibana, Brian C. Lewis, Steven A. Johnsen, and Ingolf Bach

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KLF15 is a molecular link between endoplasmic reticulum stress and insulin resistance, Dae Young Jung, UmaDevi Chalasani, Ning Pan, Randall H. Friedline, Domenick A. Prosdocimo, Minwoo Nam, Yoshihiro Azuma, Rajanikanth Maganti, Kristine Yu, Ashish Velagapudi, Bryan O'Sullivan-Murphy, Juliano L. Sartoretto, Mukesh K. Jain, Marcus P. Cooper, Fumihiko Urano, Jason K. Kim, and Susan Gray

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Role of the mixed-lineage protein kinase pathway in the metabolic stress response to obesity, Shashi Kant, Tamera Barrett, Anastassiia Vertii, Yun Hee Noh, Dae Young Jung, Jason K. Kim, and Roger J. Davis

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Widespread evidence of cooperative DNA binding by transcription factors in Drosophila development, Majid Kazemian, Hannah Pham, Scot A. Wolfe, Michael H. Brodsky, and Saurabh Sinha

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Wnt and CDK-1 regulate cortical release of WRM-1/beta-catenin to control cell division orientation in early Caenorhabditis elegans embryos, Soyoung Kim, Takao Ishidate, Rita Sharma, Martha C. Soto, Darryl Conte Jr., Craig C. Mello, and Masaki Shirayama

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Engrafted human cells generate adaptive immune responses to Mycobacterium bovis BCG infection in humanized mice, Jinhee Lee, Michael A. Brehm, Dale L. Greiner, Leonard D. Shultz, and Hardy Kornfeld

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Expression of ITGB8 in Epicardial Adipose Tissue is Highly and Directly Correlated with the Severity of Coronary Atherosclerosis, Nancy Lee, Sarah M. Nicoloro, Juerg R. Straubhaar, Melinda Darrigo, Stanley Tam, Michael P. Czech, and Timothy P. Fitzgibbons

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Expression of the Integrin Beta 8 Gene (ITGB8) in Epicardial Adipose Tissue is Highly and Directly Correlated with the Degree of Coronary Atherosclerosis, Nancy Lee, Sarah M. Nicoloro, Juerg R. Straubhaar, Melinda Darrigo, Stanley Tam, Michael P. Czech, and Timothy P. Fitzgibbons

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A small molecule inhibitor of fungal histone acetyltransferase Rtt109, Jessica Lopes da Rosa Spiegler, Vineeta Bajaj, James Spoonamore, and Paul D. Kaufman

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Diet-Induced Developmental Acceleration Independent of TOR and Insulin in C. elegans, Lesley T. MacNeil, Emma Watson, H. Efsun Arda, Lihua Julie Zhu, and Albertha J. M. Walhout

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Structural basis for membrane recruitment and allosteric activation of cytohesin family Arf GTPase exchange factors, Andrew W. Malaby, Bert van den Berg, and David G. Lambright

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Releasing the brakes on a chromatin-remodeling enzyme, Benjamin J. Manning and Craig L. Peterson

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Adipose Tissue Architecture and Gestational Weight Gain in Normoglycemic Pregnancies, Tiffany A. Moore Simas, Olga Gaelekman, Ningning Zhang, Milagros C. Rosal, Mary M. Lee, and Silvia Corvera

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An unusual two-step control of CPEB destruction by Pin1, Morris Nechama, Chien-Ling Lin, and Joel D. Richter

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Survival response to increased ceramide involves metabolic adaptation through novel regulators of glycolysis and lipolysis, Niraj K. Nirala, Motiur Rahman, Stanley M. Walls, Alka Singh, Lihua Julie Zhu, Takeshi Bamba, Eiichiro Fukusaki, Sargur M. Srideshikan, Greg L. Harris, Y. Tony Ip, Rolf Bodmer, and Usha Acharya

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Efficiency of bridging-sheet recruitment explains HIV-1 R5 envelope glycoprotein sensitivity to soluble CD4 and macrophage tropism, Olivia J. O'Connell, Alexander Repik, Jacqueline D. Reeves, Maria Paz Gonzalez-Perez, Briana Quitadamo, Elizabeth D. Anton, Maria J. Duenas-Decamp, Paul J. Peters, Rongheng Lin, Susan Zolla-Pazner, Davide Corti, Aaron Wallace, Shixia Wang, Xiang-Peng Kong, Shan Lu, and Paul R. Clapham

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Transposition-driven genomic heterogeneity in the Drosophila brain, Paola N. Perrat, Shamik DasGupta, Jie Wang, William E. Theurkauf, Zhiping Weng, Michael Rosbash, and Scott Waddell

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Absence of detectable HIV-1 viremia after treatment cessation in an infant, Deborah Persaud, Hannah Gay, Carrie Ziemniak, Ya Hui Chen, Michael Piatak Jr., Tae-Wook Chun, Matthew Strain, Douglas Richman, and Katherine Ruiz De Luzuriaga

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Human immunodeficiency viruses: propagation, quantification, and storage, Paul J. Peters, Kathryn H. Richards, and Paul R. Clapham

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Complex expression dynamics and robustness in C. elegans insulin networks, Ashlyn D. Ritter, Yuan Shen, Juan Fuxman Bass, Sankarganesh Jeyaraj, Bart Deplancke, Arnab Mukhopadjay, Jian Xu, Monica Driscoll, Heidi A. Tissenbaum, and Albertha J. M. Walhout

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beta3-Adrenergic receptor stimulation induces E-selectin-mediated adipose tissue inflammation, Rachel J. Roth Flach, Anouch Matevossian, Thomas E. Akie, Kimberly A. Negrin, Marina T. Paul, and Michael P. Czech

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Endocytic transport and cytokinesis: from regulation of the cytoskeleton to midbody inheritance, John Schiel, Carly Childs, and Rytis Prekeris

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UPF1 is Crucial for the Infectivity of Human Immunodeficiency Virus type 1 Progeny Virions, Anna Kristina Serquina, Suman R. Das, Elena Popova, Ogooluwa A. Ojelabi, Christian K. Roy, and Heinrich G. Gottlinger

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The C. elegans CSR-1 argonaute pathway counteracts epigenetic silencing to promote germline gene expression, Meetu Seth, Masaki Shirayama, Weifeng Gu, Takao Ishidate, Darryl Conte Jr., and Craig C. Mello

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Accurate identification of polyadenylation sites from 3' end deep sequencing using a naive Bayes classifier, Sarah E. Sheppard, Nathan D. Lawson, and Lihua Julie Zhu

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Recurrent and recent selective sweeps in the piRNA pathway, Alfred Simkin, Alex Wong, Yu-Ping Poh, William E. Theurkauf, and Jeffrey D. Jensen

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Jumping over the fence: RNA nuclear export revisited, Caterina Strambio-De-Castilla

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Dendritic GluN2A Synthesis Mediates Activity-Induced NMDA Receptor Insertion, Sharon A. Swanger, Yuncan A. He, Joel D. Richter, and Gary J. Bassell

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A compendium of Caenorhabditis elegans RNA binding proteins predicts extensive regulation at multiple levels, Alex M. Tamburino, Sean P. Ryder, and Albertha J. M. Walhout

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Genetic and acute CPEB1 depletion ameliorate fragile X pathophysiology, Tsuyoshi Udagawa, Natalie G. Farny, Mira Jakovcevski, Hanoch Kaphzan, Juan Marcos Alarcon, Shobha Anilkumar, Maria Ivshina, Jessica A. Hurt, Kentaro Nagaoka, Vijayalaxmi C. Nalavadi, Lori J. Lorenz, Gary J. Bassell, Schahram Akbarian, Sumantra Chattarji, Eric Klann, and Joel D. Richter

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Diet-induced obesity mediated by the JNK/DIO2 signal transduction pathway, Santiago Vernia, Julie Cavanagh-Kyros, Tamera Barrett, Dae Young Jung, Jason K. Kim, and Roger J. Davis

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Resistance to vemurafenib resulting from a novel mutation in the BRAFV600E kinase domain, Timothy R. Wagenaar, Leyuan Ma, Benjamin P. Roscoe, Sung Mi Park, Daniel N. Bolon, and Michael R. Green

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Identification of Map4k4 as a novel suppressor of skeletal muscle differentiation, Mengxi Wang, Shinya U. Amano, Rachel J. Roth Flach, Anil Chawla, Myriam Aouadi, and Michael P. Czech

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A histone acetylation switch regulates H2A.Z deposition by the SWR-C remodeling enzyme, Shinya Watanabe, Marta Radman-Livaja, Oliver J. Rando, and Craig L. Peterson

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Integration of Metabolic and Gene Regulatory Networks Modulates the C. elegans Dietary Response, Emma Watson, Lesley T. MacNeil, H. Efsun Arda, Lihua Julie Zhu, and Albertha J. M. Walhout

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Evidence for biphasic uncoating during HIV-1 infection from a novel imaging assay, Hongzhan Xu, Tamera Franks, Gregory Gibson, Kelly Huber, Nadia Rahm, Caterina Strambio De Castilla, Jeremy Luban, Christopher Aiken, Simon Watkins, Nicolas Sluis-Cremer, and Zandrea Ambrose

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Salicylate prevents virus-induced type 1 diabetes in the BBDR rat, Chaoxing Yang, Agata Jurczyk, Philip J. diIorio, Elaine Norowski, Michael A. Brehm, Christian W. Grant, Dennis L. Guberski, Dale L. Greiner, and Rita Bortell

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GABP transcription factor is required for development of chronic myelogenous leukemia via its control of PRKD2, Zhongfa Yang, Haojian Zhang, Leyuan Ma, Cong Peng, Yaoyu Chen, Junling Wang, Michael R. Green, Shaoguang Li, and Alan G. Rosmarin

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Integrative Analysis of ChIP-Chip and ChIP-Seq Dataset, Lihua Julie Zhu

Publications from 2012

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Cytoplasmic polyadenylation element binding protein deficiency stimulates PTEN and Stat3 mRNA translation and induces hepatic insulin resistance, Ilya M. Alexandrov, Maria Ivshina, Dae Young Jung, Randall H. Friedline, Hwi Jin Ko, Mei Xu, Bryan O'Sullivan-Murphy, Rita Bortell, Yen-Tsung Huang, Fumihiko Urano, Jason K. Kim, and Joel D. Richter

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Releasing the break on X chromosome inactivation: Rnf12/RLIM targets REX1 for degradation, Ingolf Bach

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Coordination of cell growth and division by the ubiquitin-proteasome system, Jennifer A. Benanti

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Engraftment of human HSCs in nonirradiated newborn NOD-scid IL2rgamma null mice is enhanced by transgenic expression of membrane-bound human SCF, Michael A. Brehm, Racki J. Waldemar, Jean H. Leif, Lisa M. Burzenski, Vishnu Hosur, Amber Wetmore, Bruce Gott, Mary Herlihy, Ronald A. Ignotz, Raymond M. Dunn, Leonard D. Shultz, and Dale L. Greiner

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Role of JNK in mammary gland development and breast cancer, Cristina Arrigo Cellurale, Nomeda Girnius, Feng Jiang, Julie Cavanagh-Kyros, Shaolei Lu, David S. Garlick, Arthur M. Mercurio, and Roger J. Davis

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Recognition models to predict DNA-binding specificities of homeodomain proteins, Ryan G. Christensen, Metewo Selase Enuameh, Marcus Blaine Noyes, Michael H. Brodsky, Scot A. Wolfe, and Gary D. Stormo

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Exploring the DNA-recognition potential of homeodomains, Stephanie W. Chu, Marcus Blaine Noyes, Ryan G. Christensen, Brian G. Pierce, Lihua Julie Zhu, Zhiping Weng, Gary D. Stormo, and Scot A. Wolfe

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Maternal immune activation alters behavior in adult offspring, with subtle changes in the cortical transcriptome and epigenome, Caroline M. Connor, Aslihan Dincer, Juerg R. Straubhaar, Janina R. Galler, Isaac B. Houston, and Schahram Akbarian

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The role of retrograde intraflagellar transport in flagellar assembly, maintenance, and function, Benjamin D. Engel, Hiroaki Ishikawa, Kimberly A. Wemmer, Stefan Geimer, Ken-ichi Wakabayashi, Masafumi Hirono, Branch Craige, Gregory J. Pazour, George B. Witman, Ritsu Kamiya, and Wallace F. Marshall

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Novel paths to antifungal therapeutics, Ahmed Fazly, Charu Jain, Reeta Prusty Rao, and Paul D. Kaufman

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NURDs are required for diversity, Thomas G. Fazzio and Oliver J. Rando

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A regulatory cascade of three transcription factors in a single specific neuron, DVC, in Caenorhabditis elegans, Huiyun Feng, John S. Reece-Hoyes, Albertha J. M. Walhout, and Ian A. Hope

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VEGF/Neuropilin-2 Regulation of Bmi-1 and Consequent Repression of IGF-IR Define a Novel Mechanism of Aggressive Prostate Cancer, Hira Lal Goel, Cheng Chang, Bryan M. Pursell, Irwin Leav, Stephen Lyle, Hualin Simon Xi, Chung-Cheng Hsieh, Helty Adisetiyo, Pradip Roy-Burman, Ilsa M. Coleman, Peter S. Nelson, Robert L. Vessella, Roger J. Davis, Stephen R. Plymate, and Arthur M. Mercurio

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The Iddm14 gene is Tcrbv-13S1A1: Prevention of Autoimmune Diabetes in the Rat with an Allele-Specific Depleting Antibody That Recognizes the Vβ13a T Cell Receptor Beta Chain, Michael Habib, Ryan Eberwine, Zhijun Liu, Thomas Herrmann, Dale Greiner, Laura Cort, Elizabeth P. Blankenhorn, and John P. Mordes

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What causes the insulin resistance underlying obesity?, Olga T. Hardy, Michael P. Czech, and Silvia Corvera

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Paternal RLIM/Rnf12 Is a Survival Factor for Milk-Producing Alveolar Cells, Baowei Jiao, Hong Ma, Maxim N. Shokhirev, Alexander Drung, Qin Yang, JongDae Shin, Shaolei Lu, Meg Byron, Sundeep Kalantry, Arthur M. Mercurio, Jeanne B. Lawrence, Alexander Hoffmann, and Ingolf Bach

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Disruption of IFT Complex A Causes Cystic Kidneys without Mitotic Spindle Misorientation, Julie A. Jonassen, Jovenal T. San Agustin, Stephen P. Baker, and Gregory J. Pazour

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First-in-class small molecule inhibitors of the single-strand DNA cytosine deaminase APOBEC3G, Ming Li, Shivender Shandilya, Michael A. Carpenter, Anurag Rathore, William L. Brown, Angela L. Perkins, Daniel A. Harki, Jonathan Solberg, Derek J. Hook, Krishan K. Pandey, Michael A. Parniak, Jeffrey R. Johnson, Nevan J. Krogan, Mohan Somasundaran, Akbar Ali, Celia A. Schiffer, and Reuben S. Harris

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Analysis of Gal4-directed transcription activation using Tra1 mutants selectively defective for interaction with Gal4, Ling Lin, Lynn Chamberlain, Lihua Julie Zhu, and Michael R. Green

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Characterization of Enhancer Function from Genome-Wide Analyses, Glenn A. Maston, Stephen G. Landt, Michael Snyder, and Michael R. Green

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Non-canonical TAF complexes regulate active promoters in human embryonic stem cells, Glenn A. Maston, Lihua Julie Zhu, Lynn Chamberlain, Ling Lin, Minggang Fang, and Michael R. Green

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Circulating microRNAs are associated with Paroxysmal or Persistent Atrial Fibrillation, David D. McManus, Jeanine Ward, Amir Y. Shaikh, Khushleen Jaggi, Victor R. Ambros, Jane Freedman, and John F. Keaney Jr.

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Rabenosyn-5 Defines the Fate of the Transferrin Receptor Following Clathrin-mediated Endocytosis, Deanna M. Navaroli, Karl D. Bellve, Clive Standley, Lawrence M. Lifshitz, James Cardia, David Lambright, Deborah Leonard, Kevin E. Fogarty, and Silvia Corvera

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Translational control of mitochondrial energy production mediates neuron morphogenesis, Aparna Oruganty-Das, Teclise Ng, Tsuyoshi Udagawa, Eyleen L. K. Goh, and Joel D. Richter

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ER stress as a trigger for beta-cell dysfunction and autoimmunity in type 1 diabetes, Bryan M. O'Sullivan-Murphy and Fumihiko Urano

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The histone demethylase jhdm1a regulates hepatic gluconeogenesis, Dongning Pan, Chunxiao Mao, Tie Zou, Annie Y. Yao, Marcus P. Cooper, Victor L. Boyartchuk, and Yong-Xu Wang

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Integration of beta-Catenin, Sirtuin, and FOXO Signaling Protects from Mutant Huntingtin Toxicity, J. Alex Parker, Rafael P. Vazquez-Manrique, Cendrine Tourette, Francesca Farina, Nicolas Offner, Arnab Mukhopadhyay, Anne-Marie Orfila, Aurelie Darbois, Sophie Menet, Heidi A. Tissenbaum, and Christian Neri

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Dynamics of the resting CD4(+) T-cell latent HIV reservoir in infants initiating HAART less than 6 months of age, Deborah Persaud, Paul E. Palumbo, Carrie Ziemniak, Michael D. Hughes, Carmelita G. Alvero, Katherine Luzuriaga, Ram Yogev, Edmund V. Capparelli, and Ellen Gould Chadwick

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The activity of Gli transcription factors is essential for Kras-induced pancreatic tumorigenesis, Mihir Rajurkar, Wilfredo E. De Jesus-Monge, David R. Driscoll, Victoria A. Appleman, He Huang, Jennifer L. Cotton, David S. Klimstra, Lihua Julie Zhu, Karl Simin, Lan Xu, Andrew P. McMahon, Brian C. Lewis, and Junhao Mao

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Gene-centered yeast one-hybrid assays, John S. Reece-Hoyes and Albertha J. M. Walhout

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PTEN Loss in the Myf5 Lineage Redistributes Body Fat and Reveals Subsets of White Adipocytes that Arise from Myf5 Precursors, Joan Sanchez-Gurmaches, Chien-Min Hung, Cynthia A. Sparks, Yuefeng Tang, Huawei Li, and David A. Guertin