The Program in Molecular Medicine at the University of Massachusetts Medical School was established in a new research building in 1989. Faculty include both clinical investigators and basic scientists, many of whom focus their research on human disease processes. The laboratory groups and core facilities that compose Molecular Medicine represent many disciplines in the bio-medical sciences: biochemistry and molecular biology, cell biology, medicine, immunology, molecular genetics and microbiology, pediatrics, pharmacology, physiology, genomics, bioinformatics and proteomics. This diverse scientific environment makes the Program an exceptional training ground for graduate students and postdoctoral fellows, who in turn contribute much to its vitality and excitement. This collection showcases publications and presentations written by faculty and researchers of the Program in Molecular Medicine.

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Publications from 2017

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Nucleosomes influence multiple steps during replication initiation, Ishara F. Azmi, Shinya Watanabe, Michael F. Maloney, Sukhyun Kang, Jason A. Belsky, David M. MacAlpine, Craig L. Peterson, and Stephen P. Bell

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Delineating CD4 dependency of HIV-1: Adaptation to infect low level CD4 expressing target cells widens cellular tropism but severely impacts on envelope functionality, David Beauparlant, Peter Rusert, Carsten Magnus, Claus Kadelka, Jacqueline Weber, Therese Uhr, Osvaldo Zagordi, Corinna Oberle, Maria J. Duenas-Decamp, Paul R. Clapham, Karin J. Metzner, Huldrych F. Gunthard, and Alexandra Trkola

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Fifteen years of research on oral-facial-digital syndromes: from 1 to 16 causal genes, Ange-Line Bruel, Thibaut Eguether, Gregory J. Pazour, and Christel Thauvin-Robinet

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Systemic insulin sensitivity is regulated by GPS2 inhibition of AKT ubiquitination and activation in adipose tissue, Carly T. Cederquist, Claudia Lentucci, Camila Martinez Calejman, Vanessa Hayashi, Joseph Orofino, David A. Guertin, Susan K. Fried, Mi-Jeong Lee, M. Dafne Cardamone, and Valentina Perissi

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An SMC-like protein binds and regulates Caenorhabditis elegans condensins, Lucy Fang-I Chao, Meha Singh, James Thompson, John R. Yates 3rd, and Kirsten A. Hagstrom

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HLH-30/TFEB-mediated autophagy functions in a cell-autonomous manner for epithelium intrinsic cellular defense against bacterial pore-forming toxin in C. elegans, Huan-Da Chen, Raffi V. Aroian, and Chang-Shi Chen

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Nrg4 promotes fuel oxidation and a healthy adipokine profile to ameliorate diet-induced metabolic disorders, Zhimin Chen, Guo-Xiao Wang, Sara L. Ma, Dae Young Jung, Hyekyung Ha, Tariq Altamimi, Xu-Yun Zhao, Liang Guo, Peng Zhang, Chun-Rui Hu, Ji-Xin Cheng, Gary D. Lopaschuk, Jason K. Kim, and Jiandie D. Lin

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JNKs function as CDK4-activating kinases by phosphorylating CDK4 and p21, B. Colleoni, S. Paternot, J. M. Pita, X. Bisteau, K. Coulonval, Roger J. Davis, E. Raspe, and P. P. Roger

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Insulin action and resistance in obesity and type 2 diabetes, Michael P. Czech

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Melanoma mystery, Roger J. Davis

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Gene Therapy with an Adeno-Associated Viral Vector Expressing Human Interleukin-2 Alters Immune System Homeostasis in Humanized Mice, Philip A. Durost, Ken-Edwin Aryee, Fatima Manzoor, Roland M. Tisch, Christian Mueller, Agata Jurczyk, Leonard D. Shultz, and Michael A. Brehm

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High pathogen burden in childhood promotes the development of unconventional innate-like CD8+ T cells, Yves T. Falanga, Michela Frascoli, Yasin Kaymaz, Catherine Forconi, John Michael Ong'echa, Jeffrey A. Bailey, Leslie J. Berg, and Ann M. Moormann

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Impaired osteogenesis of T1DM bone marrow-derived stromal cells and periosteum-derived cells and their differential in-vitro responses to growth factor rescue, Tera M. Filion, Jordan D. Skelly, Henry Huang, Dale L. Greiner, David C. Ayers, and Jie Song

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Bacterial Metabolism Affects the C. elegans Response to Cancer Chemotherapeutics, Aurian Garcia-Gonzalez, Ashlyn D. Ritter, Shaleen Shrestha, Erik C. Andersen, L. Safak Yilmaz, and Albertha J. M. Walhout

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Adipocyte lipid synthesis coupled to neuronal control of thermogenic programming, Adilson L. Guilherme, David J. Pedersen, Elizabeth Henchey, Felipe S. Henriques, Laura V. Danai, Yuefei Shen, Batuhan Yenilmez, Dae Young Jung, Jason K. Kim, Irfan J. Lodhi, Clay F. Semenkovich, and Michael P. Czech

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Loading of Extracellular Vesicles with Chemically Stabilized Hydrophobic siRNAs for the Treatment of Disease in the Central Nervous System, Reka A. Haraszti, Andrew H. Coles, Neil Aronin, Anastasia Khvorova, and Marie C. Didiot

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The Oxidative Stress Response in Caenorhabditis elegans Requires the GATA Transcription Factor ELT-3 and SKN-1/Nrf2, Queenie Hu, Dayana R. D'Amora, Lesley T. MacNeil, Albertha J. M. Walhout, and Terrance J. Kubiseski (Genetics, 6-9-2017)

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Regulation of Alloreactive CD8 T Cell Responses by Costimulation and Inflammation, Sonal Jangalwe

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Developmental Role of Macrophage Cannabinoid-1 Receptor Signaling in Type 2 Diabetes, Tony Jourdan, Gergo Szanda, Resat Cinar, Grzegorz Godlewski, David J. Holovac, Joshua K. Park, Sarah M. Nicoloro, Yuefei Shen, Jie Liu, Avi Z. Rosenberg, Ziyi Liu, Michael P. Czech, and George Kunos

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Comprehensive Transcriptome and Mutational Profiling of Endemic Burkitt Lymphoma Reveals EBV Type-Specific Differences., Yasin Kaymaz, Cliff I. Oduor, Hongbo Yu, Juliana A. Otieno, John Michael Ong'echa, Ann M. Moormann, and Jeffrey A. Bailey

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Airway smooth muscle dysfunction in Pompe (Gaa-/-) mice, Allison M. Keeler, Donghai Lui, Marina Zieger, Lang Xiong, Jeffrey Salemi, Karl D. Bellve, Barry J. Byrne, David D. Fuller, Ronghua ZhuGe, and Mai K. Elmallah

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The chemical evolution of oligonucleotide therapies of clinical utility, Anastasia Khvorova and Jonathan K. Watts

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Crystal structure of APOBEC3A bound to single-stranded DNA reveals structural basis for cytidine deamination and specificity, Takahide Kouno, Tania V. Silvas, Brendan J. Hilbert, Shivender Shandilya, Markus-Frederik Bohn, Brian A. Kelch, William E. Royer, Mohan Somasundaran, Nese Kurt Yilmaz, Hiroshi Matsuo, and Celia A. Schiffer

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Setting the (Scientific) Record Straight: Molecular and Cellular Biology Responds to Postpublication Review, Amy L. Kullas and Roger J. Davis

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mRNA-mediated glycoengineering ameliorates deficient homing of human stem cell-derived hematopoietic progenitors, Jungmin Lee, Brad Dykstra, Joel A. Spencer, Laurie L. Kenney, Dale L. Greiner, Leonard D. Shultz, Michael A. Brehm, Charles P. Lin, Robert Sackstein, and Derrick J. Rossi

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The Complex Roles of Mechanistic Target of Rapamycin in Adipocytes and Beyond, Peter L. Lee, Su Myung Jung, and David A. Guertin

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Value of circulating cell-free DNA analysis as a diagnostic tool for breast cancer: a meta-analysis, Ziqiang Lin, James Neiswender, Bin Fang, Xuelei Ma, Jing Zhang, and Xiuying Hu

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Visualization of self-delivering hydrophobically modified siRNA cellular internalization, Socheata Ly, Deanna M. Navaroli, Marie-Claire Didiot, James Cardia, Lakshmipathi Pandarinathan, Julia F. Alterman, Kevin E. Fogarty, Clive Standley, Lawrence Lifshitz, Karl D. Bellve, Matthieu Prot, Dimas Echeverria, Silvia Corvera, and Anastasia Khvorova

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Hypothalamic AMPK-ER Stress-JNK1 Axis Mediates the Central Actions of Thyroid Hormones on Energy Balance, Noelia Martinez-Sanchez, Roger J. Davis, and Miguel Lopez

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Human white adipocytes convert into "rainbow" adipocytes in vitro, Giulia Maurizi, Antonella Poloni, Silvia Corvera, and Saverio Cinti

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Regulation of Local Translation, Synaptic Plasticity, and Cognitive Function by CNOT7, Rhonda L. McFleder

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Dynamic Control of Dendritic mRNA Expression by CNOT7 Regulates Synaptic Efficacy and Higher Cognitive Function, Rhonda L. McFleder, Fernanda Mansur, and Joel D. Richter

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A microRNA family exerts maternal control on sex determination in C. elegans, Katherine McJunkin and Victor R. Ambros

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Allele-Selective Suppression of Mutant Huntingtin in Primary Human Blood Cells, James R. C. Miller, Edith L. Pfister, Wanzhao Liu, Ralph Andre, Ulrike Trager, Lori A. Kennington, Kimberly Lo, Sipke Dijkstra, Douglas Macdonald, Gary R. Ostroff, Neil Aronin, and Sarah J. Tabrizi

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Genetic disruption of oncogenic Kras sensitizes lung cancer cells to Fas receptor-mediated apoptosis, Haiwei Mou, Jill Moore, Sunil K. Malonia, Yingxiang Li, Deniz M. Ozata, Soren Hough, Chun-Qing Song, Jordan L. Smith, Andrew H. Fischer, Zhiping Weng, Michael R. Green, and Wen Xue

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CRISPR/Cas9-mediated genome editing induces exon skipping by alternative splicing or exon deletion, Haiwei Mou, Jordan L. Smith, Lingtao Peng, Jill Moore, Xiao-Ou Zhang, Chun-Qing Song, Ankur Sheel, Deniz M. Ozata, Yingxiang Li, Charles P. Emerson Jr., Erik J. Sontheimer, Melissa J. Moore, Zhiping Weng, and Wen Xue

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Ror2 signaling regulates Golgi structure and transport through IFT20 for tumor invasiveness, Michiru Nishita, Seung-Yeol Park, Tadashi Nishio, Koki Kamizaki, ZhiChao Wang, Kota Tamada, Toru Takumi, Ryuju Hashimoto, Hiroki Otani, Gregory J. Pazour, Victor W. Hsu, and Yasuhiro Minami

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Human and Epstein-Barr Virus miRNA Profiling as Predictive Biomarkers for Endemic Burkitt Lymphoma, Cliff I. Oduor, Mercedeh Movassagh, Yasin Kaymaz, Kiprotich Chelimo, Juliana A. Otieno, John M. Ong'echa, Ann M. Moormann, and Jeffrey A. Bailey

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Loss of Arf4 causes severe degeneration of the exocrine pancreas but not cystic kidney disease or retinal degeneration, Jillian N. Pearring, Jovenal T. San Agustin, Ekaterina S. Lobanova, Christopher J. Gabriel, Eric C. Lieu, William J. Monis, Michael W. Stuck, Lara Strittmatter, Samer M. Jaber, Vadim Y. Arshavsky, and Gregory J. Pazour

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Paucity of Intact Non-Induced Provirus with Early, Long-Term Antiretroviral Therapy of Perinatal HIV Infection, Kaitlin Rainwater-Lovett, Carrie Ziemniak, Douglas Watson, Katherine Luzuriaga, George Siberry, Ann Petru, YaHui Chen, Priyanka Uprety, Margaret M. McManus, Ya-Chi Ho, Susanna L. Lamers, and Deborah Persaud

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MAP4K4 impairs energy metabolism in endothelial cells and promotes insulin resistance in obesity, Rachel J. Roth Flach, Marina T. DiStefano, Laura V. Danai, Ozlem Senol-Cosar, Joseph C. Yawe, Mark Kelly, Lorena Garcia Menendez, and Michael P. Czech

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Joint analysis of left ventricular expression and circulating plasma levels of Omentin after myocardial ischemia, Louis A. Saddic, Sarah M. Nicoloro, Olga T. Gupta, Michael P. Czech, Joshua Gorham, Stanton K. Shernan, Christine E. Seidman, Jon G. Seidman, Sary F. Aranki, Simon C. Body, Timothy P. Fitzgibbons, and Jochen D. Muehlschlegel

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Amplification of Adipogenic Commitment by VSTM2A, Blandine Secco, Peter L. Lee, David A. Guertin, and Mathieu Laplante

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miRNAs cooperate in apoptosis regulation during C. elegans development, Ryan Sherrard, Sebastian Luehr, Heinke Holzkamp, Katherine McJunkin, Nadin Memar, and Barbara Conradt

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Essential role for non-canonical poly(A) polymerase GLD4 in cytoplasmic polyadenylation and carbohydrate metabolism, Jihae Shin, Ki Young Paek, Mariya Ivshina, Emily E. Stackpole, and Joel D. Richter

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Hyper- and hypo- nutrition studies of the hepatic transcriptome and epigenome suggest that PPARα regulates anaerobic glycolysis, Anthony R. Soltis, Shmulik Motola, Santiago Vernia, Christopher W. Ng, Norman J. Kennedy, Simona Dalin, Bryan J. Matthews, Roger J. Davis, and Ernest Fraenkel

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Genome-Wide CRISPR Screen Identifies Regulators of Mitogen-Activated Protein Kinase as Suppressors of Liver Tumors in Mice, Chun-Qing Song, Yingxiang Li, Haiwei Mou, Jill Moore, Angela I. Park, Soren Hough, Zachary Kennedy, Andrew H. Fischer, Darryl Conte Jr., Zhiping Weng, and Wen Xue

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Gingerenone A, a polyphenol present in ginger, suppresses obesity and adipose tissue inflammation in high-fat diet-fed mice, Sujin Suk, Gyoo Taik Kwon, Eunjung Lee, Woo Jung Jang, Hee Yang, Jong Hun Kim, N. R. Thimmegowda, Min-Yu Chung, Jung Yeon Kwon, Seunghee Yang, Jason K. Kim, Jung Han Park Yoon, and Ki Won Lee

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PRIMA: a gene-centered, RNA-to-protein method for mapping RNA-protein interactions, Alex M. Tamburino, Ebru Kaymak, Shaleen Shrestha, Amy D. Holdorf, Sean P. Ryder, and Albertha J. M. Walhout (Translation (Austin, Tex.), 2-28-2017)

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Kupffer Cell-Derived Tnf Triggers Cholangiocellular Tumorigenesis through JNK due to Chronic Mitochondrial Dysfunction and ROS, Technische Universitat München, Roger J. Davis, and Mathias Heikenwalder

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Humanized Mouse Models of Clinical Disease, Nicole C. Walsh, Laurie L. Kenney, Sonal Jangalwe, Ken-Edwin Aryee, Dale L. Greiner, Michael A. Brehm, and Leonard D. Shultz

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c-Jun N-terminal kinases (JNKs) are critical mediators of osteoblast activity in vivo, Ren Xu, Chao Zhang, Dong Yeon Shin, Jung-Min Kim, Sarfaraz Lalani, Na Li, Yeon-Suk Yang, Yifang Liu, Mark Eiseman, Roger J. Davis, Jae-Hyuck Shim, and Matthew B. Greenblatt

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Metabolic network modeling with model organisms, L. Safak Yilmaz and Albertha J. M. Walhout (Current opinion in chemical biology, 2-1-2017)

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C. elegans and its bacterial diet as a model for systems-level understanding of host-microbiota interactions, Jing Zhang, Amy D. Holdorf, and Albertha J. M. Walhout (Current opinion in biotechnology, 2-8-2017)

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Bitter taste receptors as targets for tocolytics in preterm labor therapy, Kaizhi Zheng, Ping Lu, Ellen Delpapa, Karl D. Bellve, Ruitang Deng, Jennifer C. Condon, Kevin E. Fogarty, Lawrence M. Lifshitz, Tiffany A. Moore Simas, Fangxiong Shi, and Ronghua ZhuGe

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GUIDEseq: a bioconductor package to analyze GUIDE-Seq datasets for CRISPR-Cas nucleases, Lihua Julie Zhu, Michael Lawrence, Ankit Gupta, Herve Pages, Alper Kucukural, Manuel Garber, and Scot A. Wolfe

Publications from 2016

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A Modular Assembly Platform for Rapid Generation of DNA Constructs, Elliot Akama-Garren, Nik Joshi, Tuomas Tammela, Gregory P. Chang, Bethany L. Wagner, Da-Yae Lee, William M. Rideout Iii, Thales Papagiannakopoulos, Wen Xue, and Tyler Jacks

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Examination of Huntington's disease with atypical clinical features in a Bangladeshi family tree, Md Mahfuz Al-Mamun, Suprovath Kumar Sarker, Syeda Kashfi Qadri, Tahmina Shirin, Quazi Deen Mohammad, Regina LaRocque, Elinor K. Karlsson, Narayan Saha, Muhammad Asaduzzaman, Firdausi Qadri, and Md Kaiissar Mannoor

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In vivo correction of anaemia in beta-thalassemic mice by gammaPNA-mediated gene editing with nanoparticle delivery, Raman Bahal, Dale L. Greiner, Michael A. Brehm, and Peter M. Glazer

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Platelet functional and transcriptional changes induced by intralipid infusion, Lea M. Beaulieu, Olga Vitseva, Kahraman Tanriverdi, Alper Kucukural, Eric O. Mick, Naomi Hamburg, Joseph Vita, and Jane E. Freedman

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Longevity of Genotype-Specific Immune Responses to Plasmodium falciparum Merozoite Surface Protein 1 in Kenyan Children from Regions of Different Malaria Transmission Intensity, Natalie M. Bowman, Jonathan J. Juliano, Cynthia J. Snider, Oksana Kharabora, Steven R. Meshnick, John Vulule, Chandy C. John, and Ann M. Moormann

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Tissue Compartmentalization and Tropism of HIV-1: A Dissertation, Robin L. Brese

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Factors influencing survival among Kenyan children diagnosed with endemic Burkitt lymphoma between 2003 and 2011: A historical cohort study, Geoffrey C. Buckle, Louise Maranda, Jodi Skiles, John Michael Ong'echa, Joslyn Foley, Mara M. Epstein, Terry A. Vik, Andrew Schroeder, Jennifer Lemberger, Alan G. Rosmarin, Scot C. Remick, Jeffrey A. Bailey, John Vulule, Juliana A. Otieno, and Ann M. Moormann

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ASM Journals Eliminate Impact Factor Information from Journal Websites, Arturo Casadevall, Roger J. Davis, and ASM Journal Editors and Leadership

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A Novel SMC-Like Protein Modulates C. Elegans Condensin Functions: A Dissertation, Lucy F. Chao

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Evolutionary analysis across mammals reveals distinct classes of long non-coding RNAs, Jenny Chen, Alexander A. Shishkin, Xiaopeng Zhu, Sabah Kadri, Itay Maza, Mitchell Guttman, Jacob H. Hanna, Aviv Regev, and Manuel Garber

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HIV-1 capsid is involved in post-nuclear entry steps, Nan-Yu Chen, Lihong Zhou, Paul J. Gane, Silvana Opp, Neil J. Ball, Giuseppe Nicastro, Madeleine Zufferey, Cindy Buffone, Jeremy Luban, David Selwood, Felipe Diaz-Griffero, Ian Taylor, and Ariberto Fassati

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Peptide- and Amine-Modified Glucan Particles for the Delivery of Therapeutic siRNA, Jessica L. Cohen, Yuefei Shen, Myriam Aouadi, Pranitha Vangala, Michaela Tencerova, Shinya U. Amano, Sarah M. Nicoloro, Joseph Yawe, and Michael P. Czech

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Multipolar mitosis and aneuploidy after chrysotile treatment: a consequence of abscission failure and cytokinesis regression, Beatriz Araujo Cortez, Paula Rezende-Teixeira, Sambra D. Redick, Stephen J. Doxsey, and Glaucia Maria Machado-Santelli

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Combined Activities of JNK1 and JNK2 in Hepatocytes Protect Against Toxic Liver Injury, Francisco Javier Cubero, Miguel Eugenio Zoubek, Wei Hu, Jin Peng, Gang Zhao, Yulia A. Nevzorova, Malika Al Masaoudi, Lars P. Bechmann, Mark V. Boekschoten, Michael Muller, Christian Preisinger, Nikolaus Gassler, Ali E. Canbay, Tom Luedde, Roger J. Davis, Christian Liedtke, and Christian Trautwein

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The Effects of Interleukin-10 on Skeletal Muscle Insulin Resistance and Myogenesis, Sezin Dagdeviren

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IL-10 prevents aging-associated inflammation and insulin resistance in skeletal muscle, Sezin Dagdeviren, Dae Young Jung, Randall H. Friedline, Hye Lim Noh, Jong Hun Kim, Payal R. Patel, Nicholas Tsitsilianos, Kunikazu Inashima, Duy A. Tran, Xiaodi Hu, Marilia M. Loubato, Siobhan M. Craige, Jung Yeon Kwon, Ki Won. Lee, and Jason K. Kim

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Altered Interleukin-10 Signaling in Skeletal Muscle Regulates Obesity-Mediated Inflammation and Insulin Resistance, Sezin Dagdeviren, Dae Young Jung, Eunjung Lee, Randall H. Friedline, Hye Lim Noh, Jong Hun. Kim, Payal R. Patel, Nicholas Tsitsilianos, Andrew V. Tsitsilianos, Duy A. Tran, George H. Tsougranis, Caitlyn C. Kearns, Cecilia P. Uong, Jung Yeon. Kwon, Werner Muller, Ki Won. Lee, and Jason K. Kim

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The pesticidal Cry6Aa toxin from Bacillus thuringiensis is structurally similar to HlyE-family alpha pore-forming toxins, Alexey Dementiev, Anand Sitaram, Yan Hu, Raffi V. Aroian, and Colin Berry

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End Sequence Analysis ToolKit (ESAT) expands the extractable from single cell RNA-seq experiments, Alan G. Derr, Chaoxing Yang, Rapolas Zilionis, Alexey Sergushichev, David Blodgett, Sambra D. Redick, Rita Bortell, Jeremy Luban, David Harlan, Sebastian Kadener, Dale L. Greiner, Allon Klein, Maxim Artyomov, and Manuel Garber

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Ebola Virus Glycoprotein with Increased Infectivity Dominated the 2013-2016 Epidemic, William E. Diehl, Kyusik Kim, Pyae Phyo Kyawe, Sean M. McCauley, Elisa Donnard, Alper Kucukural, Patrick E. McDonel, Manuel Garber, and Jeremy Luban

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Adipocyte-specific Hypoxia-inducible gene 2 promotes fat deposition and diet-induced insulin resistance, Marina DiStefano, Rachel J. Roth Flach, Ozlem Senol-Cosar, Laura V. Danai, Joseph V. Virbasius, Sarah M. Nicoloro, Juerg R. Straubhaar, Sezin Dagdeviren, Martin Wabitsch, Olga T. Gupta, Jason K. Kim, and Michael P. Czech

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A Role for the Lipid Droplet Protein HIG2 in Promoting Lipid Deposition in Liver and Adipose Tissue: A Dissertation, Marina T. DiStefano

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Saturation Mutagenesis of the HIV-1 Envelope CD4 Binding Loop Reveals Residues Controlling Distinct Trimer Conformations, Maria J. Duenas-Decamp, Li Jiang, Daniel N. Bolon, and Paul R. Clapham

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Dietary Betaine Supplementation Increases Fgf21 Levels to Improve Glucose Homeostasis and Reduce Hepatic Lipid Accumulation in Mice, Asma Ejaz, Jason K. Kim, Mary-Elizabeth Patti, and Carles Lerin

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Emerging evidence for beneficial macrophage functions in atherosclerosis and obesity-induced insulin resistance, Timothy P. Fitzgibbons and Michael P. Czech

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Genetic ablation of lymphocytes and cytokine signaling in nonobese diabetic mice prevents diet-induced obesity and insulin resistance, Randall H. Friedline, Hwi Jin Ko, Dae Young Jung, Yongjin Lee, Rita Bortell, Sezin Dagdeviren, Payal R. Patel, Xiaodi Hu, Kunikazu Inashima, Caitlyn C. Kearns, Nicholas Tsitsilianos, Umber Shafiq, Dale L. Greiner, and Jason K. Kim

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A gene-centered C. elegans protein-DNA interaction network provides a framework for functional predictions, Juan Fuxman Bass, Carles Pons, Lucie Kozlowski, John S. Reece-Hoyes, Shaleen Shrestha, Amy D. Holdorf, Akihiro Mori, Chad L. Myers, and Albertha J. M. Walhout

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Colony Lift Colorimetric Assay for beta-Galactosidase Activity, Juan Fuxman Bass, John S. Reece-Hoyes, and Albertha J. M. Walhout (Cold Spring Harbor protocols, 12-1-2016)

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Gene-Centered Yeast One-Hybrid Assays, Juan Fuxman Bass, John S. Reece-Hoyes, and Albertha J. M. Walhout (Cold Spring Harbor protocols, 12-1-2016)

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Generating Bait Strains for Yeast One-Hybrid Assays, Juan Fuxman Bass, John S. Reece-Hoyes, and Albertha J. M. Walhout (Cold Spring Harbor protocols, 12-1-2016)

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Performing Yeast One-Hybrid Library Screens, Juan Fuxman Bass, John S. Reece-Hoyes, and Albertha J. M. Walhout (Cold Spring Harbor protocols, 12-1-2016)

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Zymolyase-Treatment and Polymerase Chain Reaction Amplification from Genomic and Plasmid Templates from Yeast, Juan Fuxman Bass, John S. Reece-Hoyes, and Albertha J. M. Walhout (Cold Spring Harbor protocols, 12-1-2016)

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Increased Glucose-induced Secretion of Glucagon-like Peptide-1 in Mice Lacking the Carcinoembryonic Antigen-related Cell Adhesion Molecule 2 (CEACAM2), Simona S. Ghanem, Dae Young Jung, Yongjin Lee, Jason K. Kim, and Sonia M. Najjar

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TNFalpha-Mediated Cytotoxic Responses to IAP Inhibition Are Limited by the p38alpha MAPK Pathway, Nomeda Girnius and Roger J. Davis

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The RNA-binding protein ATX-2 regulates cytokinesis through PAR-5 and ZEN-4, Megan M. Gnazzo, Eva-Maria E. Uhlemann, Alex R. Villarreal, Masaki Shirayama, Eddie G. Dominguez, and Ahna R. Skop

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P-Rex1 Promotes Resistance to VEGF/VEGFR-Targeted Therapy in Prostate Cancer, Hira Lal Goel, Bryan M. Pursell, Leonard D. Shultz, Dale L. Greiner, Rolf A. Brekken, Craig W. Vander Kooi, and Arthur M. Mercurio

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Inflammation Mediated by JNK in Myeloid Cells Promotes the Development of Hepatitis and Hepatocellular Carcinoma, Myoung Souk Han, Tamera Barrett, Michael A. Brehm, and Roger J. Davis

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High-resolution proteomic and lipidomic analysis of exosomes and microvesicles from different cell sources, Reka A. Haraszti, Marie-Cecile Didiot, Ellen Sapp, John D. Leszyk, Scott A. Shaffer, Hannah E. Rockwell, Fei Gao, Niven R. Narain, Marian DiFiglia, Michael A. Kiebish, Neil Aronin, and Anastasia Khvorova

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Mechanism of early dissemination and metastasis in Her2+ mammary cancer, Kathryn L. Harper, Maria Soledad Sosa, Nomeda Girnius, Roger J. Davis, and Julio A. Aguirre-Ghiso

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Cell Signaling and Stress Responses, Gokhan S. Hotamisligil and Roger J. Davis

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mTORC2 Promotes Lipid Storage and Suppresses Thermogenesis in Brown Adipose Tissue in Part Through AKT-Independent Regulation of FoxO1: A Dissertation, Chien-Min Hung

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Roles of the Mother Centriole Appendage Protein Cenexin in Microtubule Organization during Cell Migration and Cell Division: A Dissertation, Hui-Fang Hung

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The Mother Centriole Appendage Protein Cenexin Modulates Lumen Formation through Spindle Orientation, Hui-Fan Hung, Heidi Hehnly, and Stephen J. Doxsey

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Improved B cell development in humanized NOD-scid IL2Rgammanull mice transgenically expressing human stem cell factor, granulocyte-macrophage colony-stimulating factor and interleukin-3, Sonal Jangalwe, Leonard D. Shultz, Anuja Mathew, and Michael A. Brehm