The Program in Molecular Medicine at the University of Massachusetts Medical School was established in a new research building in 1989. Faculty include both clinical investigators and basic scientists, many of whom focus their research on human disease processes. The laboratory groups and core facilities that compose Molecular Medicine represent many disciplines in the bio-medical sciences: biochemistry and molecular biology, cell biology, medicine, immunology, molecular genetics and microbiology, pediatrics, pharmacology, physiology, genomics, bioinformatics and proteomics. This diverse scientific environment makes the Program an exceptional training ground for graduate students and postdoctoral fellows, who in turn contribute much to its vitality and excitement. This collection showcases publications and presentations written by faculty and researchers of the Program in Molecular Medicine.

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Publications from 2015

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The p53R172H Mutant Does Not Enhance Hepatocellular Carcinoma Development and Progression, Leanne G. Ahronian, David R. Driscoll, David S. Klimstra, and Brian C. Lewis

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Biodistribution and function of extracellular miRNA-155 in mice, Shashi Bala, Timea Csak, Fatemeh Momen-Heravi, Dora Lippai, Karen Kodys, Donna Catalano, Abhishek Satishchandran, Victor R. Ambros, and Gyongyi Szabo

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SWI/SNF recruitment to a DNA double-strand break by the NuA4 and Gcn5 histone acetyltransferases, Gwendolyn M. Bennett and Craig L. Peterson

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Novel Observations From Next-Generation RNA Sequencing of Highly Purified Human Adult and Fetal Islet Cell Subsets, David M. Blodgett, Anetta Nowosielska, Shaked Afik, Susanne Pechhold, Anthony J. Cura, Norman J. Kennedy, Soyoung Kim, Alper Kucukural, Roger J. Davis, Sally C. Kent, Dale L. Greiner, Manuel Garber, David M. Harlan, and Philip J. diLorio Jr.

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The ssDNA Mutator APOBEC3A Is Regulated by Cooperative Dimerization, Markus-Frederik Bohn, Shivender Shandilya, Tania V. Silvas, Ellen A. Nalivaika, Takahide Kouno, Brian Kelch, Sean P. Ryder, Nese Kurt Yilmaz, Mohan Somasundaran, and Celia A. Schiffer

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DNA-binding-domain fusions enhance the targeting range and precision of Cas9, Mehmet Fatih Bolukbasi, Ankit Gupta, Sarah Oikemus, Alan G. Derr, Manuel Garber, Michael H. Brodsky, Lihua (Julie) Zhu, and Scot A. Wolfe

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DNA-binding-domain fusions enhance the targeting range and precision of Cas9, Mehmet Fatih Bolukbasi, Ankit Gupta, Sarah Oikemus, Alan G. Derr, Manuel Garber, Michael H. Brodsky, Lihua Julie Zhu, and Scot A. Wolfe

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Robust Distal Tip Cell Pathfinding in the Face of Temperature Stress Is Ensured by Two Conserved microRNAS in Caenorhabditis elegans, Samantha L. Burke, Molly Hammell, and Victor R. Ambros

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A laminin 511 matrix is regulated by TAZ and functions as the ligand for the alpha6Bbeta1 integrin to sustain breast cancer stem cells, Cheng Chang, Hira Lal Goel, Huijie Gao, Bryan M. Pursell, Leonard D. Shultz, Dale L. Greiner, Sulev Ingerpuu, Manuel Patarroyo, Shiliang Cao, Elgene Lim, Junhao Mao, Karen Kulju. McKee, Peter D. Yurchenco, and Arthur M. Mercurio

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R loops regulate promoter-proximal chromatin architecture and cellular differentiation, Poshen B. Chen, Hsiuyi V. Chen, Diwash Acharya, Oliver J. Rando, and Thomas G. Fazzio

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RNA Interference in Caenorhabditis elegans, Darryl Conte Jr., Lesley T. MacNeil, Albertha J. M. Walhout, and Craig C. Mello

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Novel Jbts17 mutant mouse model of Joubert syndrome with cilia transition zone defects and cerebellar and other ciliopathy related anomalies, Rama Rao Damerla, Cheng Cui, George C. Gabriel, Xiaoqin Liu, Branch Craige, Brian C. Gibbs, Richard Francis, You Li, Bishwanath Chatterjee, Jovenal T. San Agustin, Thibaut Eguether, Ramiah Subramanian, George B. Witman, Jacques L. Michaud, Gregory J. Pazour, and Cecilia W. Lo

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The Lipid Droplet Protein Hypoxia-inducible Gene 2 Promotes Hepatic Triglyceride Deposition by Inhibiting Lipolysis, Marina T. DiStefano, Laura V. Danai, Rachel J. Roth Flach, Anil K. Chawla, David J. Pedersen, Adilson L. Guilherme, and Michael P. Czech

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Human gene-centered transcription factor networks for enhancers and disease variants, Juan Fuxman Bass, Nidhi Sahni, Shaleen Shrestha, Aurian Garcia-Gonzalez, Akihiro Mori, Numana Bhat, Song Yi, David E. Hill, Marc Vidal, and Albertha J. M. Walhout

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Viral infection of engrafted human islets leads to diabetes, Glen R. Gallagher, Michael A. Brehm, Robert W. Finberg, Bruce A. Barton, Leonard D. Shultz, Dale L. Greiner, Rita Bortell, and Jennifer P. Wang

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Glycolytic enzymes localize to ribonucleoprotein granules in Drosophila germ cells, bind Tudor and protect from transposable elements, Ming Gao, Travis Thomson, T Michael Creed, Shikui Tu, Sudan N. Loganathan, Christina A. Jackson, Patrick McCluskey, Yanyan Lin, Scott E. Collier, Zhiping Weng, Paul Lasko, Melanie D. Ohi, and Alexey L. Arkov

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Reduced frequencies of polyfunctional CMV-specific T cell responses in infants with congenital CMV infection, Laura L. Gibson, Constance Barysauskas, Margaret M. McManus, Sheryl Dooley, Daniele Lilleri, Donna Fisher, Tumul Srivastava, Don J. Diamond, and Katherine Ruiz De Luzuriaga

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A Gene Expression Signature That Correlates with CD8+ T Cell Expansion in Acute EBV Infection, Thomas C. Greenough, Juerg R. Straubhaar, Larisa Kamga, Eric R. Weiss, Robin M. Brody, Margaret M. McManus, Linda K. Lambrecht, Mohan Somasundaran, and Katherine Ruiz De Luzuriaga

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Influenza A virus preferentially snatches noncoding RNA caps, Weifeng Gu, Glen R. Gallagher, Weiwei Dai, Ping Liu, Ruidong Li, Melanie I. Trombly, Don B. Gammon, Craig C. Mello, Jennifer P. Wang, and Robert W. Finberg

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Regulation of Nucleosome Architecture and Factor Binding Revealed by Nuclease Footprinting of the ESC Genome, Sarah J. Hainer and Thomas G. Fazzio

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Suppression of pervasive noncoding transcription in embryonic stem cells by esBAF, Sarah J. Hainer, Weifeng Gu, Benjamin R. Carone, Benjamin D. Landry, Oliver J. Rando, Craig C. Mello, and Thomas G. Fazzio

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Control of stem cell self-renewal and differentiation by the heterochronic genes and the cellular asymmetry machinery in Caenorhabditis elegans, Omid F. Harandi and Victor R. Ambros

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Transcriptional and post-transcriptional control of adipocyte differentiation by Jumonji domain-containing protein 6, Yu-Jie Hu, Houda Belaghzal, Wen-Yu Hsiao, Jun Qi, James E. Bradner, David A. Guertin, Said Sif, and Anthony N. Imbalzano

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Neutrophil Responses to Sterile Implant Materials, Siddharth Jhunjhunwala, Stephanie Aresta-DaSilva, Katherine Tang, David Alvarez, Matthew J. Webber, Benjamin C. Tang, Danya M. Lavin, Omid Veiseh, Joshua C. Doloff, Suman Bose, Arturo Vegas, Minglin Ma, Gaurav Sahay, Alan Chiu, Andrew Bader, Erin Langan, Sean Siebert, Jie Li, Dale L. Greiner, Peter E. Newburger, Ulrich H. von Andrian, Robert Langer, and Daniel G. Anderson

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IRE1 prevents endoplasmic reticulum membrane permeabilization and cell death under pathological conditions, Kohsuke Kanekura, Xiucui Ma, John T. Murphy, Lihua Julie Zhu, Abhinav Diwan, and Fumihiko Urano

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Research resource: Monitoring endoplasmic reticulum membrane integrity in beta-cells at the single-cell level, Kohsuke Kanekura, Jianhong Ou, Takashi Hara, Lihua (Julie) Zhu, and Fumihiko Urano

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Research resource: Monitoring endoplasmic reticulum membrane integrity in beta-cells at the single-cell level, Kohsuke Kanekura, Jianhong Ou, Takashi Hara, Lihua Julie Zhu, and Fumihiko Urano

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Functional annotation of native enhancers with a Cas9-histone demethylase fusion, Nicola A. Kearns, Hannah Pham, Barbara Tabak, Ryan M. J. Genga, Noah J. Silverstein, Manuel Garber, and Rene Maehr

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Studying Cellular Signal Transduction with OMIC Technologies, Benjamin D. Landry, David C. Clarke, and Michael J. Lee

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TRIM5 retroviral restriction activity correlates with the ability to induce innate immune signaling, Josefina Lascano, Pradeep Uchil, Walther Mothes, and Jeremy Luban

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A versatile reporter system for CRISPR-mediated chromosomal rearrangements, Yingxiang Li, Angela I. Park, Haiwei Mou, Cansu Colpan, Aizhan Bizhanova, Elliot Akama-Garren, Nik Joshi, Eric A. Hendrickson, David Feldser, Hao Yin, Daniel G. Anderson, Tyler Jacks, Zhiping Weng, and Wen Xue

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Transcription Factor Activity Mapping of a Tissue-Specific Gene Regulatory Network, Lesley T. MacNeil, Carles Pons, H. Efsun Arda, Gabrielle E. Giese, Chad L. Myers, and Albertha J. M. Walhout

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Prostate Tumorigenesis Induced by PTEN Deletion Involves Estrogen Receptor beta Repression, Paul Mak, Jianrong Li, Sanjoy Samanta, Cheng Chang, D. Joseph Jerry, Roger J. Davis, Irwin Leav, and Arthur M. Mercurio

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Understanding multifactorial influences on the continuum of maternal weight trajectories in pregnancy and early postpartum: study protocol, and participant baseline characteristics, Tiffany A. Moore Simas, Silvia Corvera, Mary M. Lee, Ningning Zhang, Katherine Leung, Barbara C. Olendzki, Bruce A. Barton, and Milagros C. Rosal

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Precision cancer mouse models through genome editing with CRISPR-Cas9, Haiwei Mou, Zachary Kennedy, Daniel G. Anderson, Hao Yin, and Wen Xue

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HIV-1 non-macrophage-tropic R5 envelope glycoproteins are not more tropic for entry into primary CD4+ T-cells than envelopes highly adapted for macrophages, Thomas A. Musich, Olivia O'Connell, Maria Paz Gonzalez-Perez, Cynthia A. Derdeyn, Paul J. Peters, and Paul R. Clapham

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Bunched and Madm Function Downstream of Tuberous Sclerosis Complex to Regulate the Growth of Intestinal Stem Cells in Drosophila, Yingchao Nie, Qi Li, Alla Amcheslavsky, Juan Carlos Duhart, Alexey Veraksa, Hugo Stocker, Laurel A. Raftery, and Y. Tony Ip

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Effect of transmission intensity and age on subclass antibody responses to Plasmodium falciparum pre-erythrocytic and blood-stage antigens, Gregory S. Noland, Paul Jansen, John M. Vulule, Gregory S. Park, Bartholomew N. Ondigo, James W. Kazura, Ann M. Moormann, and Chandy C. John

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Guanabenz (Wytensin) selectively enhances uptake and efficacy of hydrophobically modified siRNAs, Maire F. Osborn, Julia F. Alterman, Mehran Nikan, Hong Cao, Marie C. Didiot, Matthew R. Hassler, Andrew H. Coles, and Anastasia Khvorova

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Adipose Tissue Therapeutics for Scar Rehabilitation after Thermal Injury, Dylan Perry, Jorge R. Lujan-Hernandez, Ava Chappell, So Yun Min, Raghu Appasani, Raziel Rojas-Rodriguez, Michael S. Chin, Silvia Corvera, and Janice F. Lalikos

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Infection of ectocervical tissue and universal targeting of T-cells mediated by primary non-macrophage-tropic and highly macrophage-tropic HIV-1 R5 envelopes, Paul J. Peters, Maria Paz Gonzalez-Perez, Thomas A. Musich, Tiffany A. Moore Simas, Rongheng Lin, Abraham N. Morse, Robin J. Shattock, Cynthia A. Derdeyn, and Paul R. Clapham

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Lv4 Is a Capsid-Specific Antiviral Activity in Human Blood Cells That Restricts Viruses of the SIVMAC/SIVSM/HIV-2 Lineage Prior to Integration, Massimo Pizzato, Sean Matthew McCauley, Martha R. Neagu, Thomas Pertel, Claudia Firrito, Serena Ziglio, Ann Dauphin, Madeleine Zufferey, Lionel Berthoux, and Jeremy Luban

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Chromatin Dynamics and the RNA Exosome Function in Concert to Regulate Transcriptional Homeostasis, Mayuri Rege, Vidya Subramanian, Chenchen Zhu, Tsung-Han S. Hsieh, Assaf Weiner, Nir Friedman, Sandra Clauder-Munster, Lars M. Steinmetz, Oliver J. Rando, Laurie A. Boyer, and Craig L. Peterson

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Caenorhabditis elegans microRNAs of the let-7 family act in innate immune response circuits and confer robust developmental timing against pathogen stress, Zhiji Ren and Victor R. Ambros

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Human adipose tissue expansion in pregnancy is impaired in gestational diabetes mellitus, Raziel Rojas-Rodriguez, Tiffany A. Moore Simas, Lawrence M. Lifshitz, Karl D. Bellve, So-Yun Min, Jacqueline Pires, Katherine Leung, Crina Boeras, Aylin Sert, Jacqueline T. Draper, and Silvia Corvera

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Widespread macromolecular interaction perturbations in human genetic disorders, Nidhi Sahni, Song Yi, Mikko Taipale, Juan Fuxman Bass, Jasmin Coulombe-Huntington, Frederick P. Roth, Yu Xia, Albertha J. M. Walhout, Susan Lindquist, and Marc Vidal

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An efficient and sensitive method for preparing cDNA libraries from scarce biological samples, Catherine H. Sterling, Isana Veksler-Lublinsky, and Victor R. Ambros

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Dynamical features of the Plasmodium falciparum ribosome during translation, Ming Sun, Wen Li, Karin Blomqvist, Sanchaita Das, Yaser Hashem, Jeffrey D. Dvorin, and Joachim Frank

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Adenovirus-Mediated Somatic Genome Editing of Pten by CRISPR/Cas9 in Mouse Liver in Spite of Cas9-Specific Immune Responses, Dan Wang, Haiwei Mou, Shaoyong Li, Yingxiang Li, Soren Hough, Karen Tran, Jia Li, Hao Yin, Daniel G. Anderson, Erik J. Sontheimer, Zhiping Weng, Guangping Gao, and Wen Xue

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Lixisenatide accelerates restoration of normoglycemia and improves human beta-cell function and survival in diabetic immunodeficient NOD-scid IL-2rg(null) RIP-DTR mice engrafted with human islets, Chaoxing Yang, Matthias Loehn, Agata Jurczyk, Natalia Przewozniak, Linda Leehy, Pedro L. Herrera, Leonard D. Shultz, Dale L. Greiner, David Harlan, and Rita Bortell

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A multilaboratory comparison of calibration accuracy and the performance of external references in analytical ultracentrifugation, Huaying Zhao, Kimberly A. Crowley, Craig L. Peterson, Sarah G. Swygert, and Peter Schuck

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Caenorhabditis elegans ALG-1 antimorphic mutations uncover functions for Argonaute in microRNA guide strand selection and passenger strand disposal, Anna Y. Zinovyeva, Isana Veksler-Lublinsky, Ajay A. Vashisht, James A. Wohlschlegel, and Victor R. Ambros

Publications from 2014

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NPHP4 controls ciliary trafficking of membrane proteins and large soluble proteins at the transition zone, Junya Awata, Saeko Takada, Clive Standley, Karl-Ferdinand Lechtreck, Karl D. Bellve, Gregory J. Pazour, Kevin E. Fogarty, and George B. Witman

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Transcriptional regulation of Caenorhabditis elegans FOXO/DAF-16 modulates lifespan, Ankita Bansal, Eun-Soo Kwon, Darryl Conte Jr., Haibo Liu, Michael J. Gilchrist, Lesley T. MacNeil, and Heidi A. Tissenbaum

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Gammaretroviral pol sequences act in cis to direct polysome loading and NXF1/NXT-dependent protein production by gag-encoded RNA, Hanni Bartels and Jeremy Luban

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TRIM37 is a new histone H2A ubiquitin ligase and breast cancer oncoprotein, Sanchita Bhatnagar, Claude Gazin, Lynn Chamberlain, Jianhong Ou, Xiaochun Zhu, Jogender S. Tushir, Ching-Man A. Virbasius, Ling Lin, Lihua Julie Zhu, Narendra Wajapeyee, and Michael R. Green

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Genetic and pharmacological reactivation of the mammalian inactive X chromosome, Sanchita Bhatnagar, Xiaochun Zhu, Jianhong Ou, Ling Lin, Lynn Chamberlain, Lihua Julie Zhu, Narendra Wajapeyee, and Michael R. Green

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Spectrum and mechanisms of inflammasome activation by chitosan, Chelsea L. Bueter, Chrono K. Lee, Jennifer P. Wang, Gary R. Ostroff, Charles A. Specht, and Stuart M. Levitz

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Unbiased chromatin accessibility profiling by RED-seq uncovers unique features of nucleosome variants in vivo, Poshen B. Chen, Lihua Julie Zhu, Sarah J. Hainer, Kurtis N. McCannell, and Thomas G. Fazzio

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PSF contacts exon 7 of SMN2 pre-mRNA to promote exon 7 inclusion, Sunghee Cho, Heegyum Moon, Tiing Jen Loh, Hyun Kyung Oh, Darren Reese Williams, D. Joshua Liao, Jianhua Zhou, Michael R. Green, Xuexiu Zheng, and Haihong Shen

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Adipose tissue angiogenesis: impact on obesity and type-2 diabetes, Silvia Corvera and Olga Gaelekman

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Distinct functions for IFT140 and IFT20 in opsin transport, Jacquelin A. Crouse, Vanda S. Lopes, Jovenal T. San Agustin, Brian T. Keady, David S. Williams, and Gregory J. Pazour

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Cyclophilin A promotes HIV-1 reverse transcription but its effect on transduction correlates best with its effect on nuclear entry of viral cDNA, Alberto De Iaco and Jeremy Luban

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Differentiation between temporary and real non-clearability of biotinylated IgG antibody by avidin in mice, Shuping Dou, John Virostko, Mary Rusckowski, Dale L. Greiner, Alvin C. Powers, and Guozheng Liu

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Comparison between two labeled agents in mice using a coinjection-ratio approach in contrast to a conventional group approach, Shuping Dou, Yuzhen Wang, Bruce A. Barton, Ling Chen, Mary Rusckowski, Leonard D. Shultz, Dale L. Greiner, and Guozheng Liu

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The BRAF oncoprotein functions through the transcriptional repressor MAFG to mediate the CpG Island Methylator phenotype, Minggang Fang, Jianhong Ou, Lloyd Hutchinson, and Michael R. Green

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Arf4 is required for Mammalian development but dispensable for ciliary assembly, John A. Follit, Jovenal T. San Agustin, Julie A. Jonassen, Tingting Huang, Jaime A. Rivera-Perez, Kimberly D. Tremblay, and Gregory J. Pazour

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Transcription factor binding to Caenorhabditis elegans first introns reveals lack of redundancy with gene promoters, Juan I. Fuxman Bass, Alex M. Tamburino, Akihiro Mori, Nathan Beittel, Matthew T. Weirauch, John S. Reece-Hoyes, and Albertha J. M. Walhout

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A single vertebrate DNA virus protein disarms invertebrate immunity to RNA virus infection, Don B. Gammon, Sophie Duraffour, Daniel K. Rozelle, Heidi Hehnly, Rita Sharma, Michael E. Sparks, Cara C. West, Ying Chen, James J. Moresco, Graciela Andrei, John H. Connor, Darryl Conte Jr., Dawn E. Gundersen-Rindal, William L. Marshall, John R. Yates, Neal S. Silverman, and Craig C. Mello

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Regulated splicing of the alpha6 integrin cytoplasmic domain determines the fate of breast cancer stem cells, Hira Lal Goel, Tatiana Gritsko, Bryan Pursell, Cheng Chang, Leonard D. Shultz, Dale L. Greiner, Jens Henrik Norum, Rune Toftgard, Leslie M. Shaw, and Arthur M. Mercurio

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An improved predictive recognition model for Cys(2)-His(2) zinc finger proteins, Ankit Gupta, Ryan G. Christensen, Heather A. Bell, Mathew Goodwin, Ronak Y. Patel, Manishi Pandey, Metewo Selase Enuameh, Amy L. Rayla, Cong Zhu, Stacey Thibodeau-Beganny, Michael H. Brodsky, J. Keith Joung, Scot A. Wolfe, and Gary D. Stormo

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Synergistic tumor suppression by combined inhibition of telomerase and CDKN1A, Romi Gupta, Yuying Dong, Peter D. Solomon, Hiromi I. Wettersten, Christopher J. Cheng, JIn-Na Min, Jeremy Henson, Shaillay Kumar Dogra, Sung H. Hwang, Bruce D. Hammock, Lihua Julie Zhu, Roger R. Reddel, W. Mark Saltzman, Robert H. Weiss, Sandy Chang, Michael R. Green, and Narendra Wajapeyee

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Rab11 endosomes contribute to mitotic spindle organization and orientation, Heidi Hehnly and Stephen J. Doxsey

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The machinery at endoplasmic reticulum-plasma membrane contact sites contributes to spatial regulation of multiple Legionella effector proteins, Andree Hubber, Kohei Arasaki, Fubito Nakatsu, Camille Hardiman, David G. Lambright, Pietro De Camilli, Hiroki Nagai, and Craig R. Roy

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Rictor/mTORC2 Loss in the Myf5 Lineage Reprograms Brown Fat Metabolism and Protects Mice against Obesity and Metabolic Disease, Chien-Min Hung, Camila Martinez Calejman, Joan Sanchez-Gurmaches, Huawei Li, Clary B. Clish, Simone Hettmer, Amy J. Wagers, and David A. Guertin

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Exon 9 skipping of apoptotic caspase-2 pre-mRNA is promoted by SRSF3 through interaction with exon 8, Ha Na Jang, Minho Lee, Tiing Jen Loh, Seung-Woo Choi, Hyun Kyung Oh, Heegyum Moon, Sunghee Cho, Seong-Eui Hong, Do Han Kim, Zhi Sheng, Michael R. Green, Daeho Park, Xuexiu Zheng, and Haihong Shen

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A population of Langerin-positive dendritic cells in murine Peyer's patches involved in sampling beta-glucan microparticles, Magdia De Jesus, Gary R. Ostroff, Stuart M. Levitz, Toni R. Bartling, and Nicholas J. Mantis

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Cas9 effector-mediated regulation of transcription and differentiation in human pluripotent stem cells, Nicola A. Kearns, Ryan M. J. Genga, Metewo Selase Enuameh, Manuel Garber, Scot A. Wolfe, and Rene Maehr

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A co-CRISPR strategy for efficient genome editing in Caenorhabditis elegans, Heesun Kim, Takao Ishidate, Krishna S. Ghanta, Meetu Seth, Darryl Conte Jr., Masaki Shirayama, and Craig C. Mello

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Blockade of the programmed death-1 (PD1) pathway undermines potent genetic protection from type 1 diabetes, Nora M. Kochupurakkal, Annie J. Kruger, Sudipta Tripathi, Bing Zhu, La Tonya Adams, Daniel B. Rainbow, Aldo A. Rossini, Dale L. Greiner, Mohamed H. Sayegh, Linda S. Wicker, and Indira Guleria

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Regulation of a transcription factor network by Cdk1 coordinates late cell cycle gene expression, Benjamin D. Landry, Claudine E. Mapa, Heather E. Arsenault, Kristin E. Poti, and Jennifer A. Benanti

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A Large-Scale RNAi-Based Mouse Tumorigenesis Screen Identifies New Lung Cancer Tumor Suppressors that Repress FGFR Signaling, Ling Lin, Lynn Chamberlain, Magnolia L. Pak, Arvindhan Nagarajan, Romi Gupta, Lihua Julie Zhu, Casey M. Wright, Kwun M. Fong, Narendra Wajapeyee, and Michael R. Green

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Cancer-Relevant Splicing Factor CAPERalpha Engages the Essential Splicing Factor SF3b155 in a Specific Ternary Complex, Sarah Loerch, Alexandre Maucuer, Valerie Manceau, Michael R. Green, and Clara L. Kielkopf

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A therapeutically targetable mechanism of BCR-ABL-independent imatinib resistance in chronic myeloid leukemia, Leyuan Ma, Yi Shan, Robert Bai, Liting Xue, Christopher A. Eide, Jianhong Ou, Lihua Julie Zhu, Lloyd Hutchinson, Jan Cerny, Hanna Jean Khoury, Zhi Sheng, Brian J. Druker, Shaoguang Li, and Michael R. Green

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Direct interactions promote eviction of the Sir3 heterochromatin protein by the SWI/SNF chromatin remodeling enzyme, Benjamin J. Manning and Craig L. Peterson

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The embryonic mir-35 family of microRNAs promotes multiple aspects of fecundity in Caenorhabditis elegans, Katherine McJunkin and Victor R. Ambros

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SRSF2 promotes splicing and transcription of exon 11 included isoform in Ron proto-oncogene, Heegyum Moon, Sunghee Cho, Tiing Jen Loh, Hyun Kyung Oh, Ha Na Jang, Jianhua Zhou, Young-Soo Kwon, D. Joshua Liao, Youngsoo Jun, Soohyun Eom, Claudia Ghigna, Giuseppe Biamonti, Michael R. Green, Xuexiu Zheng, and Haihong Shen

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The hunt for protective correlates of immunity to Plasmodium falciparum malaria, Ann M. Moormann and V. Ann Stewart

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IL-1 signaling in obesity-induced hepatic lipogenesis and steatosis, Kimberly A. Negrin, Rachel J. Roth Flach, Marina T. DiStefano, Anouch Matevossian, Randall H. Friedline, Dae Young Jung, Jason K. Kim, and Michael P. Czech

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miR-14 Regulates Autophagy during Developmental Cell Death by Targeting ip3-kinase 2, Charles Nelson, Victor R. Ambros, and Eric H. Baehrecke

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MicroRNA-378 controls classical brown fat expansion to counteract obesity, Dongning Pan, Chunxiao Mao, Brian Quattrochi, Randall H. Friedline, Lihua Julie Zhu, Dae Young Jung, Jason K. Kim, Brian C. Lewis, and Yong-Xu Wang

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Diversity and expression of microRNAs in the filarial parasite, Brugia malayi, Catherine B. Poole, Weifeng Gu, Sanjay Kumar, Jingmin Jin, Paul J. Davis, David Bauche, and Larry A. McReynolds

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Drosophila Sirt2/mammalian SIRT3 deacetylates ATP synthase beta and regulates complex V activity, Motiur Rahman, Niraj K. Nirala, Alka Singh, Lihua Julie Zhu, Kaori Taguchi, Takeshi Bamba, Eiichiro Fukusaki, Leslie M. Shaw, David G. Lambright, Jairaj K. Acharya, and Usha R. Acharya

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Vpx rescue of HIV-1 from the antiviral state in mature dendritic cells is independent of the intracellular deoxynucleotide concentration, Christian Reinhard, Dario Bottinelli, Baek Kim, and Jeremy Luban

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Epstein-barr virus latent membrane protein 1 genetic variability in peripheral blood B cells and oropharyngeal fluids, Nicholas Renzette, Mohan Somasundaran, Frank E. Brewster, James Coderre, Eric R. Weiss, Margaret M. McManus, Thomas C. Greenough, Barbara Tabak, Manuel Garber, Timothy F. Kowalik, and Katherine Ruiz De Luzuriaga

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c-Myc inhibition prevents leukemia initiation in mice and impairs the growth of relapsed and induction failure pediatric T-ALL cells, Justine E. Roderick, Jessica M. Tesell, Leonard D. Shultz, Michael A. Brehm, Dale L. Greiner, Marian H. Harris, Lewis B. Silverman, Stephen E. Sallan, Alejandro Gutierrez, A. Thomas Look, Jun Qi, James E. Bradner, and Michelle A. Kelliher

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Adipocyte lineages: tracing back the origins of fat, Joan Sanchez-Gurmaches and David A. Guertin

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A KRAS-directed transcriptional silencing pathway that mediates the CpG island methylator phenotype, Ryan W. Serra, Minggang Fang, Sung Mi Park, Lloyd Hutchinson, and Michael R. Green

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RLIM is dispensable for X-chromosome inactivation in the mouse embryonic epiblast, JongDae Shin, Mary C. Wallingford, Judith Gallant, Chelsea Marcho, Baowei Jiao, Meg Byron, Michael Bossenz, Jeanne B. Lawrence, Stephen N. Jones, Jesse Mager, and Ingolf Bach

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A separable domain of the p150 subunit of human Chromatin Assembly Factor-1 promotes protein and chromosome associations with nucleoli, Corey L. Smith, Timothy D. Matheson, Daniel J. Trombly, Xiaoming Sun, Eric Campeau, Xuemei Han, John R. Yates III, and Paul D. Kaufman