Title

Adenosine attenuation of catecholamine-enhanced contractility of rat heart in vivo

UMMS Affiliation

Department of Physiology

Date

5-1991

Document Type

Article

Subjects

Adenosine; Animals; Epinephrine; Heart; Heart Ventricles; Isoproterenol; Male; Myocardial Contraction; Phenylisopropyladenosine; Rats; Rats, Inbred Strains; Xanthines

Disciplines

Cardiovascular Diseases | Physiology

Abstract

The antiadrenergic action of adenosine was examined in open- and closed-chest preparations of anesthetized rats. The positive inotropic effects of a jugular vein infusion of either isoproterenol or epinephrine were attenuated by phenylisopropyladenosine, an adenosine A1-receptor agonist. 1,3-Dipropyl,8-cyclopentylxanthine, a specific A1-receptor antagonist, inhibited the action of phenylisopropyladenosine. The results indicate that adenosine receptor-mediated mechanisms are functional in the blood-perfused rodent heart and support the possibility of a physiological role for adenosine in modulating cardiac contractility.

Rights and Permissions

Citation: Am J Physiol. 1991 May;260(5 Pt 2):H1635-9.

Related Resources

Link to article in PubMed

PubMed ID

2035682