Adenosine attenuation of catecholamine-enhanced contractility of rat heart in vivo
Department of Physiology
Adenosine; Animals; Epinephrine; Heart; Heart Ventricles; Isoproterenol; Male; Myocardial Contraction; Phenylisopropyladenosine; Rats; Rats, Inbred Strains; Xanthines
Cardiovascular Diseases | Physiology
The antiadrenergic action of adenosine was examined in open- and closed-chest preparations of anesthetized rats. The positive inotropic effects of a jugular vein infusion of either isoproterenol or epinephrine were attenuated by phenylisopropyladenosine, an adenosine A1-receptor agonist. 1,3-Dipropyl,8-cyclopentylxanthine, a specific A1-receptor antagonist, inhibited the action of phenylisopropyladenosine. The results indicate that adenosine receptor-mediated mechanisms are functional in the blood-perfused rodent heart and support the possibility of a physiological role for adenosine in modulating cardiac contractility.
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Citation: Am J Physiol. 1991 May;260(5 Pt 2):H1635-9.