Title
Role for IGFBP7 in senescence induction by BRAF
UMMS Affiliation
Program in Molecular Medicine; Program in Gene Function and Expression
Date
6-1-2010
Document Type
Article
Medical Subject Headings
*Cell Aging; Humans; Insulin-Like Growth Factor Binding Proteins; Melanocytes; Melanoma; Proto-Oncogene Proteins B-raf; Skin Neoplasms
Disciplines
Genetics and Genomics
Abstract
β-cell death is an important pathogenic component of both type 1 and type 2 diabetes. However, the specific molecular pathways and interactions involved in this process are not understood. Increasing evidence indicates that a type of cell stress called endoplasmic reticulum stress (ER stress) plays an important role in β-cell death. Here we discuss a potential paradigm of ER stress-mediated β-cell death.
Rights and Permissions
Citation: Cell. 2010 May 28;141(5):746-7. Link to article on publisher's site