The C. elegans Snail homolog CES-1 can activate gene expression in vivo and share targets with bHLH transcription factors
Authors
Reece-Hoyes, John S.Deplancke, Bart
Barrasa, M. Inmaculada
Hatzold, Julia
Smit, Ryan B.
Arda, H. Efsun
Pope, Patricia A.
Gaudet, Jeb
Conradt, Barbara
Walhout, Albertha J. M.
Document Type
Journal ArticlePublication Date
2009-04-18Keywords
AnimalsBasic Helix-Loop-Helix Transcription Factors
Binding Sites
Caenorhabditis elegans
Caenorhabditis elegans Proteins
DNA-Binding Proteins
Pharynx
Promoter Regions, Genetic
Regulatory Elements, Transcriptional
Transcription Factors
*Transcriptional Activation
Genetics and Genomics
Metadata
Show full item recordAbstract
Snail-type transcription factors (TFs) are found in numerous metazoan organisms and function in a plethora of cellular and developmental processes including mesoderm and neuronal development, apoptosis and cancer. So far, Snail-type TFs are exclusively known as transcriptional repressors. They repress gene expression by recruiting transcriptional co-repressors and/or by preventing DNA binding of activators from the basic helix-loop-helix (bHLH) family of TFs to CAGGTG E-box sequences. Here we report that the Caenorhabditis elegans Snail-type TF CES-1 can activate transcription in vivo. Moreover, we provide results that suggest that CES-1 can share its binding site with bHLH TFs, in different tissues, rather than only occluding bHLH DNA binding. Together, our data indicate that there are at least two types of CES-1 target genes and, therefore, that the molecular function of Snail-type TFs is more plastic than previously appreciated.Source
Nucleic Acids Res. 2009 Jun;37(11):3689-98. Epub 2009 Apr 16. Link to article on publisher's siteDOI
10.1093/nar/gkp232Permanent Link to this Item
http://hdl.handle.net/20.500.14038/44075PubMed ID
19372275Notes
Co-author Patricia Pope is a student in the Interdisciplinary Graduate Program in the Graduate School of Biomedical Sciences (GSBS) at UMass Medical School.
Related Resources
Link to Article in PubMedae974a485f413a2113503eed53cd6c53
10.1093/nar/gkp232
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