Title
Genomics tools for unraveling chromosome architecture
UMMS Affiliation
Program in Gene Function and Expression
Date
10-15-2010
Document Type
Article
Medical Subject Headings
Chromosomes; Chromosome Structures; Chromosome Mapping
Disciplines
Genetics and Genomics
Abstract
The spatial organization of chromosomes inside the cell nucleus is still poorly understood. This organization is guided by intra- and interchromosomal contacts and by interactions of specific chromosomal loci with relatively fixed nuclear 'landmarks' such as the nuclear envelope and the nucleolus. Researchers have begun to use new molecular genome-wide mapping techniques to uncover both types of molecular interactions, providing insights into the fundamental principles of interphase chromosome folding.
Rights and Permissions
Citation: Nat Biotechnol. 2010 Oct 13;28(10):1089-1095. Link to article on publisher's site