The binary switch that controls the life and death decisions of ER stressed beta cells
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Document Type
Journal ArticlePublication Date
2010-12-21Keywords
Endoplasmic ReticulumUnfolded Protein Response
Insulin-Secreting Cells
Diabetes Mellitus
Cell Death
Genetics and Genomics
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Show full item recordAbstract
Diabetes mellitus is a group of common metabolic disorders defined by hyperglycemia. One of the most important factors contributing to hyperglycemia is dysfunction and death of beta cells. Increasing experimental, clinical, and genetic evidence indicates that endoplasmic reticulum (ER) stress plays an important role in beta cell dysfunction and death during the progression of type 1 and type 2 diabetes as well as genetic forms of diabetes such as Wolfram syndrome. The mechanisms of ER stress-mediated beta cell dysfunction and death are complex and not homogenous. Here we review the recent key findings on the role of ER stress and the unfolded protein response (UPR) in beta cells and the mechanisms of ER stress-mediated beta cell dysfunction and death. Complete understanding of these mechanisms will lead to novel therapeutic modalities for diabetes.Source
Curr Opin Cell Biol. 2010 Dec 16. Link to article on publisher's siteDOI
10.1016/j.ceb.2010.11.005Permanent Link to this Item
http://hdl.handle.net/20.500.14038/44062PubMed ID
21168319Related Resources
Link to Article in PubMedae974a485f413a2113503eed53cd6c53
10.1016/j.ceb.2010.11.005