Program in Gene Function and Expression
Medical Subject Headings
Caenorhabditis elegans Proteins; Transcription Factors; Forkhead Transcription Factors; Insulin-Like Growth Factor I; Receptor, IGF Type 1
Genetics and Genomics
The Caenorhabditis elegans Forkhead box O transcription factor (FOXO) homolog DAF-16 functions as a central mediator of multiple biological processes such as longevity, development, fat storage, stress resistance, and reproduction. In C. elegans, similar to other systems, DAF-16 functions as the downstream target of a conserved, well-characterized insulin/insulin-like growth factor (IGF)-1 signaling pathway. This cascade is comprised of an insulin/IGF-1 receptor, which signals through a conserved PI 3-kinase/AKT pathway that ultimately downregulates DAF-16/FOXO activity. Importantly, studies have shown that multiple pathways intersect with the insulin/IGF-1 signaling pathway and impinge on DAF-16 for their regulation. Therefore, in C. elegans, the single FOXO family member, DAF-16, integrates signals from several pathways and then regulates its many downstream target genes.
Rights and Permissions
Citation: Antioxid Redox Signal. 2011 Feb 15;14(4):623-34. Epub 2010 Nov 30. Link to article on publisher's site