Chromatin-mediated Candida albicans virulence
Program in Gene Function and Expression
Medical Subject Headings
Candida albicans; Candidiasis; Chromatin; DNA Repair; Genomic Instability; Host-Pathogen Interactions; Humans; Transcription, Genetic; Virulence
Biochemistry | Genetics and Genomics | Immunopathology | Pathogenic Microbiology
Candida albicans is the most prevalent human fungal pathogen. To successfully propagate an infection, this organism relies on the ability to change morphology, express virulence-associated genes and resist DNA damage caused by the host immune system. Many of these events involve chromatin alterations that are crucial for virulence. This review will focus on the studies that have been conducted on how chromatin function affects pathogenicity of C. albicans and other fungi. This article is part of a Special Issue entitled: Histone chaperones and Chromatin assembly.
Rights and Permissions
Citation: Jessica Lopes da Rosa, Paul D. Kaufman, Chromatin-mediated Candida albicans virulence, Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms, Volume 1819, Issues 3–4, March–April 2012, Pages 349-355, http://dx.doi.org/10.1016/j.bbagrm.2011.08.007.
Candida albicans, Rtt109, Histone H3 lysine 56, Chromatin modification, DNA damage, Fungal pathogen