Title

Effects of aneuploidy on cellular physiology and cell division in haploid yeast

UMMS Affiliation

Program in Gene Function and Expression; Program in Molecular Medicine

Date

8-17-2007

Document Type

Article

Medical Subject Headings

*Aneuploidy; Cell Division; *Cell Proliferation; Chromosomes, Fungal; G1 Phase; Gene Expression Regulation, Fungal; Genes, Fungal; Glucose; Haploidy; Phenotype; Protein Synthesis Inhibitors; Saccharomyces cerevisiae; Saccharomyces cerevisiae Proteins; Temperature; Transcription, Genetic

Disciplines

Cancer Biology | Cell Biology | Cellular and Molecular Physiology | Genetics and Genomics

Abstract

Aneuploidy is a condition frequently found in tumor cells, but its effect on cellular physiology is not known. We have characterized one aspect of aneuploidy: the gain of extra chromosomes. We created a collection of haploid yeast strains that each bear an extra copy of one or more of almost all of the yeast chromosomes. Their characterization revealed that aneuploid strains share a number of phenotypes, including defects in cell cycle progression, increased glucose uptake, and increased sensitivity to conditions interfering with protein synthesis and protein folding. These phenotypes were observed only in strains carrying additional yeast genes, which indicates that they reflect the consequences of additional protein production as well as the resulting imbalances in cellular protein composition. We conclude that aneuploidy causes not only a proliferative disadvantage but also a set of phenotypes that is independent of the identity of the individual extra chromosomes.

Rights and Permissions

Citation: Science. 2007 Aug 17;317(5840):916-24. Link to article on publisher's site

Comments

At the time of publication, Eduardo Torres was not yet affiliated with the University of Massachusetts Medical School.

Related Resources

Link to Article in PubMed

PubMed ID

17702937