Releasing the break on X chromosome inactivation: Rnf12/RLIM targets REX1 for degradation
Program in Gene Function and Expression; Program in Molecular Medicine
Medical Subject Headings
X Chromosome Inactivation
Genetics and Genomics
One of the two X chromosomes in cells of female mammals is transcriptionally silenced in a process known as X chromosome inactivation (XCI). Initiation of XCI is regulated by the ubiquitin ligase Rnf12/RLIM, but the mechanisms by which Rnf12/RLIM mediates this process has been a mystery. A recent study by Gontan et al. shows that Rnf12/RLIM targets REX1, an inhibitor of XCI, for proteasomal degradation, providing an answer to this question.
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Citation: Cell Res. 2012 Jun 26. doi: 10.1038/cr.2012.98. Link to article on publisher's site