Title
Releasing the break on X chromosome inactivation: Rnf12/RLIM targets REX1 for degradation
UMMS Affiliation
Program in Gene Function and Expression; Program in Molecular Medicine
Date
6-26-2012
Document Type
Article
Medical Subject Headings
X Chromosome Inactivation
Disciplines
Genetics and Genomics
Abstract
One of the two X chromosomes in cells of female mammals is transcriptionally silenced in a process known as X chromosome inactivation (XCI). Initiation of XCI is regulated by the ubiquitin ligase Rnf12/RLIM, but the mechanisms by which Rnf12/RLIM mediates this process has been a mystery. A recent study by Gontan et al. shows that Rnf12/RLIM targets REX1, an inhibitor of XCI, for proteasomal degradation, providing an answer to this question.
Rights and Permissions
Citation: Cell Res. 2012 Jun 26. doi: 10.1038/cr.2012.98. Link to article on publisher's site