Title

Releasing the break on X chromosome inactivation: Rnf12/RLIM targets REX1 for degradation

UMMS Affiliation

Program in Gene Function and Expression; Program in Molecular Medicine

Date

6-26-2012

Document Type

Article

Medical Subject Headings

X Chromosome Inactivation

Disciplines

Genetics and Genomics

Abstract

One of the two X chromosomes in cells of female mammals is transcriptionally silenced in a process known as X chromosome inactivation (XCI). Initiation of XCI is regulated by the ubiquitin ligase Rnf12/RLIM, but the mechanisms by which Rnf12/RLIM mediates this process has been a mystery. A recent study by Gontan et al. shows that Rnf12/RLIM targets REX1, an inhibitor of XCI, for proteasomal degradation, providing an answer to this question.

Rights and Permissions

Citation: Cell Res. 2012 Jun 26. doi: 10.1038/cr.2012.98. Link to article on publisher's site

Related Resources

Link to Article in PubMed

PubMed ID

22785560