NURDs are required for diversity
Program in Gene Function and Expression; Program in Molecular Medicine; Department of Biochemistry and Molecular Pharmacology
Medical Subject Headings
Mi-2 Nucleosome Remodeling and Deacetylase Complex
Biochemistry, Biophysics, and Structural Biology | Genetics and Genomics
Embryonic stem cells (ESCs) can maintain their undifferentiated state indefinitely in culture (self-renewal), but must also retain the ability to differentiate into the various cell types found in the body (pluripotency). The co-existence of these two properties requires a balance between stable maintenance of ESC identity and the flexibility to reprogram cellular identity upon receiving a differentiation signal. The mechanisms underlying this developmental flexibility are largely unknown.
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Citation: EMBO J. 2012 May 11. doi: 10.1038/emboj.2012.137. Link to article on publisher's site