Program in Gene Function and Expression; Program in Systems Biology; Department of Biochemistry and Molecular Pharmacology
Medical Subject Headings
Repressor Proteins; DNA-Binding Proteins; Chromosomal Proteins, Non-Histone; Neurons; Gene Expression Regulation
Genetics and Genomics
In the brain neurons form extensively intermingled projections and synaptic interactions between them. To achieve proper neural connectivity, interactions between sections belonging to the same neuron are avoided. However, how can a cell tell, when it encounters another neuronal projection, whether it is part of the same cell? In other words, how do neurons become self-aware?
Dekker, Job, "CTCF and cohesin help neurons raise their self-awareness" (2012). Program in Gene Function and Expression Publications and Presentations. 192.