Program in Systems Biology; Program in Gene Function and Expression
Medical Subject Headings
Gene Expression Regulation
Genetics and Genomics
Recent advances in sequencing technologies have uncovered a world of RNAs that do not code for proteins, known as non-protein coding RNAs, that play important roles in gene regulation. Along with histone modifications and transcription factors, non-coding RNA is part of a layer of transcriptional control on top of the DNA code. This layer of components and their interactions specifically enables (or disables) the modulation of three-dimensional folding of chromatin to create a context for transcriptional regulation that underlies cell-specific transcription. In this perspective, we propose a structural and functional hierarchy, in which the DNA code, proteins and non-coding RNAs act as context creators to fold chromosomes and regulate genes.
Gibcus, Johan H. and Dekker, Job, "The context of gene expression regulation" (2012). Program in Gene Function and Expression Publications and Presentations. 189.