Coordination of cell growth and division by the ubiquitin-proteasome system
Program in Gene Function and Expression; Program in Molecular Medicine
Medical Subject Headings
Ubiquitin-Protein Ligase Complexes; Ubiquitin; Cell Cycle; Proteolysis
Genetics and Genomics
The coupling of cellular growth and division is crucial for a cell to make an accurate copy of itself. Regulated protein degradation by the ubiquitin-proteasome system (UPS) plays an important role in the coordination of these two processes. Many ubiquitin ligases, in particular the Skp1-Cullin-F-box (SCF) family and the Anaphase-Promoting Complex (APC), couple growth and division by targeting cell cycle and metabolic regulators for degradation. However, many regulatory proteins are targeted by multiple ubiquitin ligases. As a result, we are only just beginning to understand the complexities of the proteolytic regulatory network that connects cell growth and the cell cycle.
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Citation: Semin Cell Dev Biol. 2012 Apr 19. [Epub ahead of print] doi 10.1016/j.semcdb.2012.04.005