Translocation mapping exposes the risky lifestyle of B cells
Program in Gene Function and Expression; Department of Biochemistry and Molecular Pharmacology; Program in Systems Biology
Medical Subject Headings
Genetics and Genomics
Recurrent chromosomal translocations can drive oncogenesis, but how they form has remained elusive. Now, Chiarle et al. (2011) and Klein et al. (2011) characterize the genome-wide spectrum of translocations that form from a single double-stranded break, revealing that specific loci have an intrinsic predisposition for frequent chromosomal rearrangements.
Rights and Permissions
Citation: Cell. 2011 Sep 30;147(1):20-2. Link to article on publisher's site