Translocation mapping exposes the risky lifestyle of B cells
Program in Gene Function and Expression; Department of Biochemistry and Molecular Pharmacology; Program in Systems Biology
Medical Subject Headings
Genetics and Genomics
Recurrent chromosomal translocations can drive oncogenesis, but how they form has remained elusive. Now, Chiarle et al. (2011) and Klein et al. (2011) characterize the genome-wide spectrum of translocations that form from a single double-stranded break, revealing that specific loci have an intrinsic predisposition for frequent chromosomal rearrangements.
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Citation: Cell. 2011 Sep 30;147(1):20-2. Link to article on publisher's site
McCord, Rachel Patton and Dekker, Job, "Translocation mapping exposes the risky lifestyle of B cells" (2011). Program in Gene Function and Expression Publications and Presentations. Paper 172.