Title

Translocation mapping exposes the risky lifestyle of B cells

UMMS Affiliation

Program in Gene Function and Expression; Department of Biochemistry and Molecular Pharmacology; Program in Systems Biology

Date

9-30-2011

Document Type

Article

Medical Subject Headings

Translocation, Genetic

Disciplines

Genetics and Genomics

Abstract

Recurrent chromosomal translocations can drive oncogenesis, but how they form has remained elusive. Now, Chiarle et al. (2011) and Klein et al. (2011) characterize the genome-wide spectrum of translocations that form from a single double-stranded break, revealing that specific loci have an intrinsic predisposition for frequent chromosomal rearrangements.

Rights and Permissions

Citation: Cell. 2011 Sep 30;147(1):20-2. Link to article on publisher's site

Related Resources

Link to Article in PubMed