Title
Translocation mapping exposes the risky lifestyle of B cells
UMMS Affiliation
Program in Gene Function and Expression; Department of Biochemistry and Molecular Pharmacology; Program in Systems Biology
Date
9-30-2011
Document Type
Article
Medical Subject Headings
Translocation, Genetic
Disciplines
Genetics and Genomics
Abstract
Recurrent chromosomal translocations can drive oncogenesis, but how they form has remained elusive. Now, Chiarle et al. (2011) and Klein et al. (2011) characterize the genome-wide spectrum of translocations that form from a single double-stranded break, revealing that specific loci have an intrinsic predisposition for frequent chromosomal rearrangements.
Rights and Permissions
Citation: Cell. 2011 Sep 30;147(1):20-2. Link to article on publisher's site
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