Title

Forward and reverse genetic approaches for the analysis of vertebrate development in the zebrafish

UMMS Affiliation

Program in Gene Function and Expression; Department of Biochemistry and Molecular Pharmacology

Date

7-19-2011

Document Type

Article

Medical Subject Headings

Zebrafish; Genetic Techniques

Disciplines

Genetics and Genomics

Abstract

The development of facile forward and reverse genetic approaches has propelled the deconvolution of gene function in biology. While the origins of these techniques reside in the study of single-cell or invertebrate organisms, in many cases these approaches have been applied to vertebrate model systems to gain powerful insights into gene function during embryonic development. This perspective provides a summary of the major forward and reverse genetic approaches that have contributed to the study of vertebrate gene function in zebrafish, which has become an established model for the study of animal development.

Rights and Permissions

Citation: Dev Cell. 2011 Jul 19;21(1):48-64. Link to article on publisher's site

Related Resources

Link to Article in PubMed

PubMed ID

21763608