Program in Gene Function and Expression; Program in Molecular Medicine
Medical Subject Headings
Gene Regulatory Networks
Genetics and Genomics
Gene regulatory networks (GRNs) are rapidly being delineated, but their quality and biological meaning are often questioned. Here, I argue that biological meaning is challenging to define and discuss reasons why GRN validation should be interpreted cautiously.
Rights and Permissions
Citation: Genome Biol. 2011 Apr 11;12(4):109. Link to article on publisher's site
Walhout, Albertha J. M., "What does biologically meaningful mean? A perspective on gene regulatory network validation" (2011). Program in Gene Function and Expression Publications and Presentations. Paper 158.