Title

Chromatin globules: a common motif of higher order chromosome structure

UMMS Affiliation

Program in Gene Function and Expression; Department of Biochemistry and Molecular Pharmacology

Date

6-15-2011

Document Type

Article

Medical Subject Headings

Chromatin; Chromosome Structures; Protein Conformation

Disciplines

Genetics and Genomics

Abstract

Recent technological advances in the field of chromosome conformation capture are facilitating tremendous progress in the ability to map the three-dimensional (3D) organization of chromosomes at a resolution of several Kb and at the scale of complete genomes. Here we review progress in analyzing chromosome organization in human cells by building 3D models of chromatin based on comprehensive chromatin interaction datasets. We describe recent experiments that suggest that long-range interactions between active functional elements are sufficient to drive folding of local chromatin domains into compact globular states. We propose that chromatin globules are commonly formed along chromosomes, in a cell type specific pattern, as a result of frequent long-range interactions among active genes and nearby regulatory elements. Further, we speculate that increasingly longer range interactions can drive aggregation of groups of globular domains. This process would yield a compartmentalized chromosome conformation, consistent with recent observations obtained with genome-wide chromatin interaction mapping.

Rights and Permissions

Citation: Curr Opin Cell Biol. 2011 Jun;23(3):325-31. Epub 2011 Apr 12. Link to article on publisher's site

Related Resources

Link to Article in PubMed

PubMed ID

21489772