[Stress signaling from the endoplasmic reticulum]
Program in Gene Function and Expression; Program in Molecular Medicine
Medical Subject Headings
Activating Transcription Factor 6; Animals; Cell Differentiation; DNA-Binding Proteins; Endoplasmic Reticulum; Membrane Glycoproteins; Membrane Proteins; *Protein Folding; Protein-Serine-Threonine Kinases; Saccharomyces cerevisiae; Saccharomyces cerevisiae Proteins; Signal Transduction; Stress, Physiological; Transcription Factors; eIF-2 Kinase
Genetics and Genomics
Secretory or transmembrane types proteins can perform their functions for the first time just by being correctly folded into 3D structures. The process of folding is elaborately controlled. The important cell organ for this folding is endoplasmic reticulum (ER). Abnormality in folding is recognized as ER stress in cells, and adaptive response caused by the stress is called "unfolded protein response" (UPR). This article describes molecular mechanisms during the process from ER stress to UPR.
Rights and Permissions
Citation: Tanpakushitsu Kakusan Koso. 2004 May;49(7 Suppl):1002-5.
This document is currently not available here.