Title

[Stress signaling from the endoplasmic reticulum]

UMMS Affiliation

Program in Gene Function and Expression; Program in Molecular Medicine

Date

6-1-2004

Document Type

Article

Medical Subject Headings

Activating Transcription Factor 6; Animals; Cell Differentiation; DNA-Binding Proteins; Endoplasmic Reticulum; Membrane Glycoproteins; Membrane Proteins; *Protein Folding; Protein-Serine-Threonine Kinases; Saccharomyces cerevisiae; Saccharomyces cerevisiae Proteins; Signal Transduction; Stress, Physiological; Transcription Factors; eIF-2 Kinase

Disciplines

Genetics and Genomics

Abstract

Secretory or transmembrane types proteins can perform their functions for the first time just by being correctly folded into 3D structures. The process of folding is elaborately controlled. The important cell organ for this folding is endoplasmic reticulum (ER). Abnormality in folding is recognized as ER stress in cells, and adaptive response caused by the stress is called "unfolded protein response" (UPR). This article describes molecular mechanisms during the process from ER stress to UPR.

Rights and Permissions

Citation: Tanpakushitsu Kakusan Koso. 2004 May;49(7 Suppl):1002-5.

Comments

Article is in Japanese.

Related Resources

Link to Article in PubMed

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