This collection showcases the journal articles, book chapters, and other publications and presentations written by faculty and researchers of the Program in Gene Function and Expression (PGFE) at the University of Massachusetts Medical School.

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Publications from 2014

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Transcriptional regulation of Caenorhabditis elegans FOXO/DAF-16 modulates lifespan, Ankita Bansal, Eun-Soo Kwon, Darryl Conte Jr., Haibo Liu, Michael J. Gilchrist, Lesley T. MacNeil, and Heidi A. Tissenbaum

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Estrogen defines the dorsal-ventral limit of VEGF regulation to specify the location of the hemogenic endothelial niche, Kelli J. Carroll, Virginie Esain, Maija K. Garnaas, Mauricio Cortes, Michael C. Dovey, Sahar Nissim, Gregory M. Frechette, Sarah Y. Liu, Wanda Kwan, Claire C. Cutting, James M. Harris, Daniel A. Gorelick, Marnie E. Halpern, Nathan D. Lawson, Wolfram Goessling, and Trista E. North

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PSF contacts exon 7 of SMN2 pre-mRNA to promote exon 7 inclusion, Sunghee Cho, Heegyum Moon, Tiing Jen Loh, Hyun Kyung Oh, Darren Reese Williams, D. Joshua Liao, Jianhua Zhou, Michael R. Green, Xuexiu Zheng, and Haihong Shen

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An improved predictive recognition model for Cys2-His2 zinc finger proteins, Ankit Gupta, Ryan G. Christensen, Heather A. Bell, Mathew Goodwin, Ronak Y. Patel, Manishi Pandey, Metewo Selase Enuameh, Amy L. Rayla, Cong Zhu, Stacey Thibodeau-Beganny, Michael H. Brodsky, J. Keith Joung, Scot A. Wolfe, and Gary D. Stormo

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Exon 9 skipping of apoptotic caspase-2 pre-mRNA is promoted by SRSF3 through interaction with exon 8, Ha Na Jang, Minho Lee, Tiing Jen Loh, Seung-Woo Choi, Hyun Kyung Oh, Heegyum Moon, Sunghee Cho, Seong-Eui Hong, Do Han Kim, Zhi Sheng, Michael R. Green, Daeho Park, Xuexiu Zheng, and Haihong Shen

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Cas9 effector-mediated regulation of transcription and differentiation in human pluripotent stem cells, Nicola A. Kearns, Ryan M. J. Genga, Metewo Selase Enuameh, Manuel Garber, Scot A. Wolfe, and Rene Maehr

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Regulation of a transcription factor network by Cdk1 coordinates late cell cycle gene expression, Benjamin D. Landry, Claudine E. Mapa, Heather E. Arsenault, Kristin E. Poti, and Jennifer A. Benanti

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Cancer-Relevant Splicing Factor CAPERalpha Engages the Essential Splicing Factor SF3b155 in a Specific Ternary Complex, Sarah Loerch, Alexandre Maucuer, Valerie Manceau, Michael R. Green, and Clara L. Kielkopf

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Ceramide transfer protein deficiency compromises organelle function and leads to senescence in primary cells, Raghavendra Pralhada Rao, Luana Scheffer, Sargur M. Srideshikan, Velayoudame Parthibane, Teresa Kosakowska-Cholody, M. Athar Masood, Kunio Nagashima, Prabhakar Gudla, Stephen Lockett, Usha Acharya, and Jairaj K. Acharya

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Activated wnt signaling in stroma contributes to development of pancreatic mucinous cystic neoplasms, Makoto Sano, David R. Driscoll, Wilfredo E. De Jesus-Monge, David S. Klimstra, and Brian C. Lewis

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A KRAS-directed transcriptional silencing pathway that mediates the CpG island methylator phenotype, Ryan W. Serra, Minggang Fang, Sung Mi Park, Lloyd Hutchinson, and Michael R. Green

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RLIM is dispensable for X-chromosome inactivation in the mouse embryonic epiblast, JongDae Shin, Mary C. Wallingford, Judith Gallant, Chelsea Marcho, Baowei Jiao, Meg Byron, Michael Bossenz, Jeanne B. Lawrence, Stephen N. Jones, Jesse Mager, and Ingolf Bach

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The Nef-like effect of murine leukemia virus glycosylated gag on HIV-1 infectivity is mediated by its cytoplasmic domain and depends on the AP-2 adaptor complex, Yoshiko Usami, Sergei Popov, and Heinrich G. Gottlinger

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NrasG12D oncoprotein inhibits apoptosis of pre-leukemic cells expressing Cbfbeta-SMMHC via activation of MEK/ERK axis, Liting Xue, John A. Pulikkan, Peter J. Valk, and Lucio H. Castilla

Publications from 2013

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Hdac6 regulates Tip60-p400 function in stem cells, Poshen B. Chen, Jui-Hung Hung, Taylor L. Hickman, Andrew H. Coles, James F. Carey, Zhiping Weng, Feixia Chu, and Thomas G. Fazzio

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p16 Stimulates CDC42-Dependent Migration of Hepatocellular Carcinoma Cells, Ya-Wen Chen, Hsiao-Chien Chu, Ze-Shiang Lin, Wei-Jyh Shiah, Chen-Pin Chou, David S. Klimstra, and Brian C. Lewis

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MicroRNA Control of Vascular Endothelial Growth Factor Signaling Output During Vascular Development, Lan T. H. Dang, Nathan D. Lawson, and Jason E. Fish

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Exploring the three-dimensional organization of genomes: interpreting chromatin interaction data, Job Dekker, Marc A. Marti-Renom, and Leonid A. Mirny

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Global analysis of Drosophila Cys2-His2 zinc finger proteins reveals a multitude of novel recognition motifs and binding determinants, Metewo Selase Enuameh, Yuna Asriyan, Adam Richards, Ryan G. Christensen, Victoria L. Hall, Majid Kazemian, Cong Zhu, Hannah Pham, Qiong Cheng, Charles Blatti, Jessie A. Brasefield, Matthew D. Basciotta, Jianhong Ou, Joseph C. McNulty, Lihua Julie Zhu, Susan E. Celniker, Saurabh Sinha, Gary D. Stormo, Michael H. Brodsky, and Scot A. Wolfe

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MEN1 is a Melanoma Tumor Suppressor that Preserves Genomic Integrity by Stimulating Transcription of Genes that Promote Homologous Recombination-Directed DNA Repair, Minggang Fang, Fen Xia, Meera Mahalingam, Ching-Man A. Virbasius, Narendra Wajapeyee, and Michael R. Green

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Chemical screening identifies filastatin, a small molecule inhibitor of Candida albicans adhesion, morphogenesis, and pathogenesis, Ahmed Fazly, Charu Jain, Amie C. Dehner, Luca Issi, Elizabeth A. Lilly, Akbar Ali, Hong Cao, Paul L. Fidel Jr., Reeta P. Rao, and Paul D. Kaufman

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Targeted chromosomal deletions and inversions in zebrafish, Ankit Gupta, Victoria L. Hall, Fatma O. Kok, Masahiro Shin, Joseph C. McNulty, Nathan D. Lawson, and Scot A. Wolfe

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Specific Requirement of Gli Transcription Factors in Hedgehog-mediated Intestinal Development, He Huang, Jennifer L. Cotton, Yang Wang, Mihir Rajurkar, Lihua Julie Zhu, Brian C. Lewis, and Junhao Mao

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U2AF65 adapts to diverse pre-mRNA splice sites through conformational selection of specific and promiscuous RNA recognition motifs, Jermaine L. Jenkins, Anant A. Agrawal, Ankit Gupta, Michael R. Green, and Clara L. Kielkopf

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Functional activity of RLIM/Rnf12 is regulated by phosphorylation-dependent nucleo-cytoplasmic shuttling, Baowei Jiao, Naoko Taniguchi-Ishigaki, Cenap Gungor, Marvin A. Peters, Ya-Wen Chen, Sabine Riethdorf, Alexander Drung, Leanne G. Ahronian, JongDae Shin, Rachna Pagnis, Klaus Pantel, Taro Tachibana, Brian C. Lewis, Steven A. Johnsen, and Ingolf Bach

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Widespread evidence of cooperative DNA binding by transcription factors in Drosophila development, Majid Kazemian, Hannah Pham, Scot A. Wolfe, Michael H. Brodsky, and Saurabh Sinha

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A small molecule inhibitor of fungal histone acetyltransferase Rtt109, Jessica Lopes da Rosa Spiegler, Vineeta Bajaj, James Spoonamore, and Paul D. Kaufman

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Diet-Induced Developmental Acceleration Independent of TOR and Insulin in C. elegans, Lesley T. MacNeil, Emma Watson, H. Efsun Arda, Lihua Julie Zhu, and Albertha J. M. Walhout

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Efficient targeted mutagenesis in the monarch butterfly using zinc finger nucleases, Christine Merlin, Lauren E. Beaver, Orley R. Taylor, Scot A. Wolfe, and Steven M. Reppert

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Post-transcriptional mechanisms contribute to Etv2 repression during vascular development, John C. Moore, Sarah Sheppard, Ilya A. Shestopalov, James K. Chen, and Nathan D. Lawson

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Survival response to increased ceramide involves metabolic adaptation through novel regulators of glycolysis and lipolysis, Niraj K. Nirala, Motiur Rahman, Stanley M. Walls, Alka Singh, Lihua Julie Zhu, Takeshi Bamba, Eiichiro Fukusaki, Sargur M. Srideshikan, Greg L. Harris, Y. Tony Ip, Rolf Bodmer, and Usha Acharya

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Suppression of Gluconeogenic Gene Expression by LSD1-Mediated Histone Demethylation, Dongning Pan, Chunxiao Mao, and Yong-Xu Wang

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Architectural Protein Subclasses Shape 3D Organization of Genomes during Lineage Commitment, Jennifer E. Phillips-Cremins, Michael E. G. Sauria, Amartya Sanyal, Tatiana I. Gerasimova, Bryan R. Lajoie, Joshua S. K. Bell, Chin-Tong Ong, Tracy A. Hookway, Changying Guo, Yuhua Sun, Michael J. Bland, William Wagstaff, Stephen Dalton, Todd C. McDevitt, Ranjan Sen, Job Dekker, James Taylor, and Victor G. Corces

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Extensive Rewiring and Complex Evolutionary Dynamics in a C. elegans Multiparameter Transcription Factor Network, John S. Reece-Hoyes, Carles Pons, Alos Diallo, Akihiro Mori, Shaleen Shrestha, Sreenath Kadreppa, Justin Nelson, Stephanie Diprima, Amelie Dricot, Bryan R. Lajoie, Philippe Souza Moraes Ribeiro, Matthew T. Weirauch, David E. Hill, Timothy R. Hughes, Chad L. Myers, and Albertha J. M. Walhout

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Complex expression dynamics and robustness in C. elegans insulin networks, Ashlyn D. Ritter, Yuan Shen, Juan Fuxman Bass, Sankarganesh Jeyaraj, Bart Deplancke, Arnab Mukhopadjay, Jian Xu, Monica Driscoll, Heidi A. Tissenbaum, and Albertha J. M. Walhout

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UPF1 is Crucial for the Infectivity of Human Immunodeficiency Virus type 1 Progeny Virions, Anna Kristina Serquina, Suman R. Das, Elena Popova, Ogooluwa A. Ojelabi, Christian K. Roy, and Heinrich G. Gottlinger

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Accurate identification of polyadenylation sites from 3' end deep sequencing using a naive Bayes classifier, Sarah E. Sheppard, Nathan D. Lawson, and Lihua Julie Zhu

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Identification of both copy number variation-type and constant-type core elements in a large segmental duplication region of the mouse genome, Juzoh Umemori, Akihiro Mori, Kenji Ichiyanagi, Takeaki Uno, and Tsuyoshi Koide

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A truncation allele in vascular endothelial growth factor c reveals distinct modes of signaling during lymphatic and vascular development, Jacques A. Villefranc, Stefania Nicoli, Katie Bentley, Michael Jeltsch, Georgia Zarkada, John C. Moore, Holger Gerhardt, Kari Alitalo, and Nathan D. Lawson

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C. elegans sirtuins, Mohan Viswanathan and Heidi A. Tissenbaum

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Resistance to vemurafenib resulting from a novel mutation in the BRAFV600E kinase domain, Timothy R. Wagenaar, Leyuan Ma, Benjamin P. Roscoe, Sung Mi Park, Daniel N. Bolon, and Michael R. Green

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TRIB2 Acts Downstream of Wnt/TCF in Liver Cancer Cells to Regulate YAP and C/EBPalpha Function, Jiayi Wang, Joo-Seop Park, Yingying Wei, Mihir Rajurkar, Jennifer L. Cotton, Qishi Fan, Brian C. Lewis, Hongkai Ji, and Junhao Mao

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Integration of Metabolic and Gene Regulatory Networks Modulates the C. elegans Dietary Response, Emma Watson, Lesley T. MacNeil, H. Efsun Arda, Lihua Julie Zhu, and Albertha J. M. Walhout

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GABP transcription factor is required for development of chronic myelogenous leukemia via its control of PRKD2, Zhongfa Yang, Haojian Zhang, Leyuan Ma, Cong Peng, Yaoyu Chen, Junling Wang, Michael R. Green, Shaoguang Li, and Alan G. Rosmarin

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Using defined finger-finger interfaces as units of assembly for constructing zinc-finger nucleases, Cong Zhu, Ankit Gupta, Victoria L. Hall, Amy L. Rayla, Ryan G. Christensen, Benjamin Dake, Abirami Lakshmanan, Charlotte Kuperwasser, Gary D. Stormo, and Scot A. Wolfe

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Integrative Analysis of ChIP-Chip and ChIP-Seq Dataset, Lihua Julie Zhu

Publications from 2012

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Cytoplasmic polyadenylation element binding protein deficiency stimulates PTEN and Stat3 mRNA translation and induces hepatic insulin resistance, Ilya M. Alexandrov, Maria Ivshina, Dae Young Jung, Randall H. Friedline, Hwi Jin Ko, Mei Xu, Bryan O'Sullivan-Murphy, Rita Bortell, Yen-Tsung Huang, Fumihiko Urano, Jason K. Kim, and Joel D. Richter

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Releasing the break on X chromosome inactivation: Rnf12/RLIM targets REX1 for degradation, Ingolf Bach

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Hi-C: A comprehensive technique to capture the conformation of genomes, Jon-Matthew Belton, Rachel Patton McCord, Johan H. Gibcus, Natalia Naumova, Ye Zhan, and Job Dekker

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Coordination of cell growth and division by the ubiquitin-proteasome system, Jennifer A. Benanti

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Recognition models to predict DNA-binding specificities of homeodomain proteins, Ryan G. Christensen, Metewo Selase Enuameh, Marcus Blaine Noyes, Michael H. Brodsky, Scot A. Wolfe, and Gary D. Stormo

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Exploring the DNA-recognition potential of homeodomains, Stephanie W. Chu, Marcus Blaine Noyes, Ryan G. Christensen, Brian G. Pierce, Lihua Julie Zhu, Zhiping Weng, Gary D. Stormo, and Scot A. Wolfe

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Recent trends in post-discharge mortality among patients with an initial acute myocardial infarction, Andrew H. Coles, Kimberly A. Fisher, Chad E. Darling, David D. McManus, Oscar Maitas, Jorge L. Yarzebski, Joel M. Gore, Darleen M. Lessard, and Robert J. Goldberg

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Understanding the mechanisms of IGF2 gene regulation in hepatocellular carcinoma cells, Amalene Cooper-Morgan, Natalia Naumova, Amartya Sanyal, Bryan R. Lajoie, Job Dekker, and Brian C. Lewis

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International trends in pancreatic cancer incidence and mortality rates, Wilfredo E. DeJesus-Monge and Bruce A. Barton

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CTCF and cohesin help neurons raise their self-awareness, Job Dekker

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Novel paths to antifungal therapeutics, Ahmed Fazly, Charu Jain, Reeta Prusty Rao, and Paul D. Kaufman

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NURDs are required for diversity, Thomas G. Fazzio and Oliver J. Rando

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A regulatory cascade of three transcription factors in a single specific neuron, DVC, in Caenorhabditis elegans, Huiyun Feng, John S. Reece-Hoyes, Albertha J. M. Walhout, and Ian A. Hope

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From cells to chromatin: Capturing snapshots of genome organization with 5C technology, Maria A. Ferraiuolo, Amartya Sanyal, Natalia Naumova, Job Dekker, and Josee Dostie

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Wolfram syndrome 1 and adenylyl cyclase 8 interact at the plasma membrane to regulate insulin production and secretion, Sonya G. Fonseca, Fumihiko Urano, Gordon C. Weir, Jesper Gromada, and Mark Burcin

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The context of gene expression regulation, Johan H. Gibcus and Job Dekker

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An optimized two-finger archive for ZFN-mediated gene targeting, Ankit Gupta, Amy L. Rayla, Abirami Lakshmanan, Scot A. Wolfe, Ryan G. Christensen, and Gary D. Stormo

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Iterative correction of Hi-C data reveals hallmarks of chromosome organization, Maxim Imakaev, Geoffrey Fudenberg, Rachel Patton McCord, Natalia Naumova, Anton Goloborodko, Bryan R. Lajoie, Job Dekker, and Leonid A. Mirny

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Paternal RLIM/Rnf12 Is a Survival Factor for Milk-Producing Alveolar Cells, Baowei Jiao, Hong Ma, Maxim N. Shokhirev, Alexander Drung, Qin Yang, JongDae Shin, Shaolei Lu, Meg Byron, Sundeep Kalantry, Arthur M. Mercurio, Jeanne B. Lawrence, Alexander Hoffmann, and Ingolf Bach

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F-box protein specificity for g1 cyclins is dictated by subcellular localization, Benjamin D. Landry, John P. Doyle, David P. Toczyski, and Jennifer A. Benanti

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Analysis of Gal4-directed transcription activation using Tra1 mutants selectively defective for interaction with Gal4, Ling Lin, Lynn Chamberlain, Lihua Julie Zhu, and Michael R. Green

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Chromatin-mediated Candida albicans virulence, Jessica Lopes da Rosa and Paul D. Kaufman

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Characterization of Enhancer Function from Genome-Wide Analyses, Glenn A. Maston, Stephen G. Landt, Michael Snyder, and Michael R. Green

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Non-canonical TAF complexes regulate active promoters in human embryonic stem cells, Glenn A. Maston, Lihua Julie Zhu, Lynn Chamberlain, Ling Lin, Minggang Fang, and Michael R. Green

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Analysis of long-range chromatin interactions using Chromosome Conformation Capture, Natalia Naumova, Emily M. Smith, Ye Zhan, and Job Dekker

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miR-221 is required for endothelial tip cell behaviors during vascular development, Stefania Nicoli, Carl-Philipp Knyphausen, Lihua Julie Zhu, Abirami Lakshmanan, and Nathan D. Lawson

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ER stress as a trigger for beta-cell dysfunction and autoimmunity in type 1 diabetes, Bryan M. O'Sullivan-Murphy and Fumihiko Urano

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The histone demethylase jhdm1a regulates hepatic gluconeogenesis, Dongning Pan, Chunxiao Mao, Tie Zou, Annie Y. Yao, Marcus P. Cooper, Victor L. Boyartchuk, and Yong-Xu Wang

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Integration of beta-Catenin, Sirtuin, and FOXO Signaling Protects from Mutant Huntingtin Toxicity, J. Alex Parker, Rafael P. Vazquez-Manrique, Cendrine Tourette, Francesca Farina, Nicolas Offner, Arnab Mukhopadhyay, Anne-Marie Orfila, Aurelie Darbois, Sophie Menet, Heidi A. Tissenbaum, and Christian Neri

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Thrombopoietin/MPL participates in initiating and maintaining RUNX1-ETO acute myeloid leukemia via PI3K/AKT signaling, John A. Pulikkan, Dmitri Madera, Liting Xue, Paul Bradley, Sean F. Landrette, Ya-Huei Kuo, Saman Abbas, Lihua Julie Zhu, Peter J. Valk, and Lucio H. Castilla

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The activity of Gli transcription factors is essential for Kras-induced pancreatic tumorigenesis, Mihir Rajurkar, Wilfredo E. De Jesus-Monge, David R. Driscoll, Victoria A. Appleman, He Huang, Jennifer L. Cotton, David S. Klimstra, Lihua Julie Zhu, Karl Simin, Lan Xu, Andrew P. McMahon, Brian C. Lewis, and Junhao Mao

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Gene-centered yeast one-hybrid assays, John S. Reece-Hoyes and Albertha J. M. Walhout

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The classical pink-eyed dilution mutation affects angiogenic responsiveness, Michael S. Rogers, Victor L. Boyartchuk, Richard M. Rohan, Amy E. Birsner, William F. Dietrich, and Robert J. D'Amato

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The long-range interaction landscape of gene promoters, Amartya Sanyal, Bryan R. Lajoie, Gaurav Jain, and Job Dekker

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Large-scale population analysis challenges the current criteria for the molecular diagnosis of fascioscapulohumeral muscular dystrophy, Isabella Scionti, Francesca Greco, Giulia Ricci, Monica Govi, Patricia Arashiro, Liliana Vercelli, Angela Berardinelli, Corrado Angelini, Giovanni Antonini, Michelangelo Cao, Antonio Di Muzio, Maurizio Moggio, Lucia Morandi, Enzo Ricci, Carmelo Rodolico, Lucia Ruggiero, Lucio Santoro, Gabriele Siciliano, Giuliano Tomelleri, Carlo Pietro Trevisan, Giuliana Galluzzi, Woodring E. Wright, Mayana Zatz, and Rossella Ginevra Tupler

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Transcriptional consequences of aneuploidy, Jason M. Sheltzer, Eduardo M. Torres, Maitreya J. Dunham, and Angelika Amon

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Genetics, Life Span, Health Span, and the Aging Process in Caenorhabditis elegans, Heidi A. Tissenbaum

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Regulation of CHMP4/ESCRT-III function in human immunodeficiency virus type 1 budding by CC2D1A, Yoshiko Usami, Sergei Popov, Eric R. Weiss, Christie Vriesema-Magnuson, Arianna Calistri, and Heinrich G. Gottlinger

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Transcription factor ATF5 is required for terminal differentiation and survival of olfactory sensory neurons, Shu-Zong Wang, Jianhong Ou, Lihua Julie Zhu, and Michael R. Green

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A Synthetic Interaction Screen Identifies Factors Selectively Required for Proliferation and TERT Transcription in p53-Deficient Human Cancer Cells, Li Xie, Claude Gazin, Sung Mi Park, Lihua Julie Zhu, Marie-Anne Debily, Ellen L. W. Kittler, Maria L. Zapp, David S. Lapointe, Stephane Gobeil, Ching-Man A. Virbasius, and Michael R. Green

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The Blk pathway functions as a tumor suppressor in chronic myeloid leukemia stem cells, Haojian Zhang, Cong Peng, Yiguo Hu, Huawei Li, Zhi Sheng, Yaoyu Chen, Con Sullivan, Jan Cerny, Lloyd Hutchinson, Anne Higgins, Patricia M. Miron, Xueqing Zhang, Michael A. Brehm, Dongguang Li, Michael R. Green, and Shaoguang Li

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Chondrolectin mediates growth cone interactions of motor axons with an intermediate target, Zhen Zhong, Jochen Ohnmacht, Michell M. Reimer, Ingolf Bach, Thomas C. Becker, and Catherina G. Becker

Publications from 2011

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Genomics in 2011: challenges and opportunities, David J. Adams, Bonnie Berger, Olivier Harismendy, Curtis Huttenhower, X. Shirley Liu, Chad L. Myers, Alicia Oshlack, John L. Rinn, and Albertha J. M. Walhout

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Identification of cis regulatory features in the embryonic zebrafish genome through large-scale profiling of H3K4me1 and H3K4me3 binding sites, Aaron W. Aday, Lihua Julie Zhu, Abirami Lakshmanan, Jie Wang, and Nathan D. Lawson

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The three-dimensional folding of the α-globin gene domain reveals formation of chromatin globules, Davide Bau, Amartya Sanyal, Bryan R. Lajoie, Emidio Capriotti, Meg Byron, Jeanne B. Lawrence, Job Dekker, and Marc A. Marti-Renom

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A stele-enriched gene regulatory network in the Arabidopsis root, Siobhan M. Brady, Lifang Zhang, Molly Megraw, Natalia Julia Martinez, Eric Jiang, Charles S. Yi, Weilin Liu, Anna Zeng, Mallorie Taylor-Teeples, Dahae Kim, Sebastian Ahnert, Uwe Ohler, Doreen Ware, Albertha J. M. Walhout, and Philip N. Benfey

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A modified bacterial one-hybrid system yields improved quantitative models of transcription factor specificity, Ryan G. Christensen, Ankit Gupta, Zheng Zuo, Lawrence A. Schriefer, Scot A. Wolfe, and Gary D. Stormo

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The cilia protein IFT88 is required for spindle orientation in mitosis, Benedicte Delaval, Alison Bright, Nathan D. Lawson, and Stephen J. Doxsey

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Centrin depletion causes cyst formation and other ciliopathy-related phenotypes in zebrafish, Benedicte Delaval, Laurence D. Covassin, Nathan D. Lawson, and Stephen J. Doxsey

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Using a structural and logics systems approach to infer bHLH-DNA binding specificity determinants, Federico De Masi, Christian A. Grove, Anastasia Vedenko, Andreu Alibés, Stephen S. Gisselbrecht, Luis Serrano, Martha L. Bulyk, and Albertha J. M. Walhout

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Endoplasmic reticulum stress and pancreatic beta-cell death, Sonya G. Fonseca, Jesper Gromada, and Fumihiko Urano

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Enhanced Y1H assays for Arabidopsis, Allison Gaudinier, Lifang Zhang, John S. Reece-Hoyes, Mallorie Taylor-Teeples, Li Pu, Zhijie Liu, Ghislain Breton, Jose L. Pruneda-Paz, Dahae Kim, Steve A. Kay, Albertha J. M. Walhout, Doreen Ware, and Siobhan M. Brady

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Zinc finger protein-dependent and -independent contributions to the in vivo off-target activity of zinc finger nucleases, Ankit Gupta, Xiangdong Meng, Lihua Julie Zhu, Nathan D. Lawson, and Scot A. Wolfe

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The COPI vesicle complex binds and moves with survival motor neuron within axons, Cyril P. Jayakumar, Matthew C. Evans, Venugopal Thayanithy, Naoko Taniguchi-Ishigaki, Ingolf Bach, Adrianne L. Kolpak, Gary J. Bassell, Rossoll Wilfried, Christian L. Lorson, Zheng-Zheng Bao, and Elliot J. Androphy