Title

Functional CpG methylation system in a social insect

UMMS Affiliation

Department of Cell and Developmental Biology

Date

10-28-2006

Document Type

Article

Medical Subject Headings

Amino Acid Sequence; Animals; Base Composition; Bees; Computational Biology; DNA; DNA (Cytosine-5-)-Methyltransferase; *DNA Methylation; DNA-Binding Proteins; Dinucleoside Phosphates; Genes, Insect; Genome, Insect; Insect Proteins; Molecular Sequence Data

Disciplines

Bioinformatics | Cell Biology | Developmental Biology | Molecular Biology | Molecular Genetics

Abstract

DNA methylation systems are well characterized in vertebrates, but methylation in Drosophila melanogaster and other invertebrates remains controversial. Using the recently sequenced honey bee genome, we present a bioinformatic, molecular, and biochemical characterization of a functional DNA methylation system in an insect. We report on catalytically active orthologs of the vertebrate DNA methyltransferases Dnmt1 and Dnmt3a and b, two isoforms that contain a methyl-DNA binding domain, genomic 5-methyl-deoxycytosine, and CpG-methylated genes. The honey bee provides an opportunity to study the roles of methylation in social contexts.

Rights and Permissions

Citation: Science. 2006 Oct 27;314(5799):645-7. Link to article on publisher's site

Comments

At the time of publication, Peter Jones was not yet affiliated with the University of Massachusetts Medical School.

Related Resources

Link to Article in PubMed

PubMed ID

17068262