Title

DNA repair in a chromatin environment

UMMS Affiliation

Department of Cell and Developmental Biology

Date

9-1-2004

Document Type

Article

Medical Subject Headings

Animals; Chromatin; DNA Damage; *DNA Repair; Histones; Humans; Nucleosomes

Disciplines

Cell Biology | Developmental Biology | Molecular Biology | Molecular Genetics

Abstract

DNA mutations and aberrations are a problem for all forms of life. Eukaryotes specifically have developed ways of identifying and repairing various DNA mutations in a complex and refractory chromatin environment. The chromatin structure is much more than a packaging unit for DNA; it is dynamic. Cells utilize and manipulate chromatin for gene regulation, genome organization and maintenance of genome integrity. Once a DNA aberration has occurred, the various DNA repair machineries interact with chromatin proteins, such as the histone variant H2A.X, and chromatin remodeling machines of the SWI/SNF family to gain access and repair the lesion in a timely manner. Recent studies have thus begun to address the roles of chromatin proteins in DNA repair as well as to dissect the functions of DNA repair machinery in vitro on more physiological, nucleosomal templates.

Rights and Permissions

Citation: Cell Mol Life Sci. 2004 Sep;61(17):2148-53. Link to article on publisher's site

Comments

At the time of publication, Peter Jones was not yet affiliated with the University of Massachusetts Medical School.

Related Resources

Link to Article in PubMed

Keywords

Chromatin, histone modifications, DNA repair, transcription, H2A.X

PubMed ID

15338044