Title

Scalpel or Straitjacket: CRISPR/Cas9 Approaches for Muscular Dystrophies

UMMS Affiliation

Department of Cell and Developmental Biology

Date

2-22-2016

Document Type

Article

Disciplines

Bioinformatics | Cell Biology | Computational Biology | Developmental Biology | Genomics | Molecular Biology | Molecular Genetics | Musculoskeletal Diseases | Nervous System Diseases

Abstract

Versatility of CRISPR/Cas9-based platforms makes them promising tools for the correction of diverse genetic/epigenetic disorders. Here we contrast the use of these genome editing tools in two myopathies with very different molecular origins: Duchenne muscular dystrophy, a monogenetic disease, and facioscapulohumeral muscular dystrophy, an epigenetic disorder with unique therapeutic challenges.

Rights and Permissions

Citation: Himeda CL, Jones TI, Jones PL. Scalpel or Straitjacket: CRISPR/Cas9 Approaches for Muscular Dystrophies. Trends Pharmacol Sci. 2016 Feb 22. pii:S0165-6147(16)00025-0. doi: 10.1016/j.tips.2016.02.001. [Epub ahead of print] PubMed PMID: 26917062. Link to article on publisher's site

Related Resources

Link to Article in PubMed

PubMed ID

26917062