Title

N-CoR-HDAC corepressor complexes: roles in transcriptional regulation by nuclear hormone receptors

UMMS Affiliation

Department of Cell and Developmental Biology

Date

2-25-2003

Document Type

Book Chapter

Medical Subject Headings

Animals; Chromatin; DNA-Binding Proteins; *Gene Expression Regulation; HeLa Cells; Histone Deacetylases; Humans; Nuclear Proteins; Nuclear Receptor Co-Repressor 1; Nuclear Receptor Co-Repressor 2; Receptors, Cytoplasmic and Nuclear; Repressor Proteins; *Transcription, Genetic; Xenopus laevis

Disciplines

Cell Biology | Developmental Biology | Molecular Biology | Molecular Genetics

Abstract

Many nuclear hormone receptors (NHRs) actively repress the expression of their primary response genes through the recruitment of transcriptional corepressor complexes to regulated promoters. N-CoR and the highly related SMRT were originally isolated and characterized by their ability to interact exclusivelywith the unliganded forms of NHRs and confer transcriptional repression. Recently, both the N-CoR and SMRT corepressors have been found to exist in vivo in multiple, distinct macromolecular complexes. While these corepressor complexes differ in overall composition, a general theme is that they contain histone deacetylase enzymatic activity. Several of these complexes contain additional transcriptional corepressor proteins with functional ties to chromatin structure. Together, these data suggest that modulation of chromatin structure plays a central role in N-CoR mediated transcriptional repression from unliganded NHRs.

Rights and Permissions

Citation: Curr Top Microbiol Immunol. 2003;274:237-68.

Comments

At the time of publication, Peter Jones was not yet affiliated with the University of Massachusetts Medical School.

Related Resources

Link to Article in PubMed

PubMed ID

12596910