Using hyperpolarized 3He MRI to evaluate treatment efficacy in cystic fibrosis patients
Authors
Sun, YanpingO'Sullivan, Brian P.
Roche, John P.
Walvick, Ronn P.
Reno, Austin
Baker, Dawn
Mansour, Joey
Albert, Mitchell
Document Type
Journal ArticlePublication Date
2011-11-01Keywords
Cystic FibrosisMagnetic Resonance Imaging
Allergy and Immunology
Pediatrics
Radiology
Respiratory Tract Diseases
Metadata
Show full item recordAbstract
PURPOSE: To use hyperpolarized (HP) (3)He MR imaging to assess functional lung ventilation in subjects with cystic fibrosis (CF) before and after treatment. MATERIALS AND METHODS: We performed HP (3)He static ventilation MRI scans on three subjects, using a Philips 3.0 Tesla (T) Achieva MRI scanner, before and after 11 days of in-patient treatment with combined intravenous and inhaled therapies for pulmonary exacerbations of CF. We also collected spirometry data. We quantified pulmonary ventilation volume measured with HP (3)He MRI using an advanced semi-automated analysis technique. RESULTS: Following 11 days of treatment with intravenous antibiotics, hypertonic saline, and rhDNase, HP (3)He MR images in one subject displayed a 25% increase in total ventilation volume. Total ventilation volume in the other two subjects slightly decreased. All three subjects showed increases in FEV(1) and FVC following treatment. CONCLUSION: In all subjects, the HP (3)He MR images provided detailed information on precisely where in the lungs gas was reaching. These data provide additional support for the conclusion that HP noble gas MRI can be a powerful tool for evaluating lung ventilation in patients with cystic fibrosis, but also raise important questions about the correlation between spirometry and HP gas MRI measurements.Source
Sun, YP; O'Sullivan, BP; Roche, JP; Walvick, R; Reno, A; Baker, D; Mansour, JK; Albert, MS. (2011) Using Hyperpolarized 3He MRI to Evaluate Treatment Efficacy in Cystic Fibrosis Patients. Journal of Magnetic Resonance Imaging 2011 Nov;34(5):1206-11. doi: 10.1002/jmri.22724. Epub 2011 Sep 19.DOI
10.1002/jmri.22724Permanent Link to this Item
http://hdl.handle.net/20.500.14038/43851PubMed ID
21932361Related Resources
Link to article in PubMedae974a485f413a2113503eed53cd6c53
10.1002/jmri.22724