This collection showcases the journal articles and other publications authored by faculty and researchers in the Division of Pulmonary and Allergy in the Department of Pediatrics at the University of Massachusetts Medical School.

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Publications from 2016

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Therapeutic rAAVrh10 Mediated SOD1 Silencing in Adult SOD1(G93A) Mice and Nonhuman Primates, Florie Borel, Gwladys Gernoux, Brynn Cardozo, Jake P. Metterville, Gabriela Toro Cabrera, Lina Song, Qin Su, Guang Ping Gao, Mai K. Elmallah, Robert H. Brown Jr., and Christian Mueller

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Self-Complementary Adeno-Associated Virus Vectors Improve Transduction Efficiency of Corneal Endothelial Cells, Anja K. Gruenert, Marta Czugala, Christian Mueller, Marco Schmeer, Martin Schleef, Friedrich E. Kruse, and Thomas A. Fuchsluger

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Development of rAAV2-CFTR: History of the First rAAV Vector Product to be Used in Humans, Heather S. Loring, Mai K. Elmallah, and Terence R. Flotte

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Adeno-associated virus-delivered artificial microRNA extends survival and delays paralysis in an amyotrophic lateral sclerosis mouse model, Lorelei Stoica, Sophia H. Todeasa, Gabriela Toro Cabrera, Johnny Salameh, Mai K. Elmallah, Christian Mueller, Robert H. Brown Jr., and Miguel Sena-Esteves

Publications from 2015

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Targeted gene delivery to the enteric nervous system using AAV: a comparison across serotypes and capsid mutants, Matthew J. Benskey, Nathan C. Kuhn, James J. Galligan, Joanna Garcia, Shannon E. Boye, William W. Hauswirth, Christian Mueller, Sanford L. Boye, and Fredric P. Manfredsson

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Adeno-Associated Virus Type 2 and Hepatocellular Carcinoma, Kenneth I. Berns, Barry J. Byrne, Terence R. Flotte, Guang Ping Gao, William W. Hauswirth, Roland W. Herzog, Nicholas Muzyczka, Thierry VandenDriessche, Xiao Xiao, Sergei Zolotukhin, and Arun Srivastava

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Delivery of Adeno-Associated Virus Gene Therapy by Intravascular Limb Infusion Methods, Alisha Gruntman and Terence R. Flotte

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Progress with Recombinant Adeno-Associated Virus Vectors for Gene Therapy of Alpha-1 Antitrypsin Deficiency, Alisha Gruntman and Terence R. Flotte

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Hereditary mucoepithelial dysplasia and severe respiratory distress, Mahmoud Halawa, Mutasim N. Abu-Hasan, and Mai K. Elmallah

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Efficient and Targeted Transduction of Nonhuman Primate Liver With Systemically Delivered Optimized AAV3B Vectors, Shaoyong Li, Li Zhong, Mengxin Li, Qin Su, Ran He, Qiushi Tang, Dale L. Greiner, Michael A. Brehm, Terence R. Flotte, Christian Mueller, and Guangping Gao

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Current status of gene therapy for alpha-1 antitrypsin deficiency, Heather S. Loring and Terence R. Flotte

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Human C9ORF72 Hexanucleotide Expansion Reproduces RNA Foci and Dipeptide Repeat Proteins but Not Neurodegeneration in BAC Transgenic Mice, Owen M. Peters, Gabriela Toro Cabrera, Helene Tran, Jeanne E. McKeon, Jake P. Metterville, Alexandra Weiss, Nicholas Wightman, Johnny Salameh, Huaming Sun, Zachary Kennedy, Ziqiang Lin, Fen-Biao Gao, Peter Sapp, Daryl Bosco, Christian Mueller, and Robert H. Brown Jr.

Publications from 2013

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A single intravenous rAAV injection as late as P20 achieves efficacious and sustained CNS Gene therapy in canavan mice, Seemin Seher Ahmed, Huapeng Li, Chunyan Cao, Elif M. Sikoglu, Andrew R. Denninger, Qin Su, Samuel Eaton, Ana A. Liso Navarro, Jun Xie, Sylvia Szucs, Hongwei Zhang, Constance M. Moore, Daniel A. Kirschner, Thomas N. Seyfried, Terence R. Flotte, Reuben Matalon, and Guangping Gao

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Gene transfer in the liver using recombinant adeno-associated virus, Seemin Seher Ahmed, Jia Li, Jonathan G. Godwin, Guangping Gao, and Li Zhong

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Birth of a new therapeutic platform: 47 years of adeno-associated virus biology from virus discovery to licensed gene therapy, Terence R. Flotte

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Gene transfer in skeletal and cardiac muscle using recombinant adeno-associated virus, Alisha M. Gruntman, Lawrence T. Bish, Christian Mueller, H. Lee Sweeney, Terence R. Flotte, and Guangping Gao

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Human Treg responses allow sustained recombinant adeno-associated virus-mediated transgene expression, Christian Mueller, Jeffrey D. Chulay, Bruce C. Trapnell, Margaret Humphries, Brenna Carey, Robert A. Sandhaus, Noel G. McElvaney, Louis M. Messina, Qiushi Tang, Farshid N. Rouhani, Martha Campbell-Thompson, Ann Dongtao Fu, Anthony Yachnis, David R. Knop, Guo-Jie Ye, Mark Brantly, Roberto Calcedo, Suryanarayan Somanathan, Lee P. Richman, Robert H. Vonderheide, Maigan A. Hulme, Todd M. Brusko, James M. Wilson, and Terence R. Flotte

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Gene-based therapy for alpha-1 antitrypsin deficiency, Christian Mueller and Terence R. Flotte

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Evolution of pancreatic function during the first year in infants with cystic fibrosis, Brian P. O'Sullivan, Dawn Baker, Katherine G. Leung, George W. Reed, Susan S. Baker, and Drucy Borowitz

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Infection control in cystic fibrosis: share and share alike, Brian P. O'Sullivan and Christopher M. Sassetti

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Translating the genomics revolution: the need for an international gene therapy consortium for monogenic diseases, Jacques P. Tremblay, Terence R. Flotte, and Guangping Gao

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Recombinant adeno-associated virus integration sites in murine liver after ornithine transcarbamylase gene correction, Li Zhong, Nirav Malani, Mengxin Li, Troy Brady, Jun Xie, Peter Bell, Shaoyong Li, Haven Jones, James M. Wilson, Terence R. Flotte, Frederic D. Bushman, and Guangping Gao

Publications from 2012

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Induction of Group IVC Phospholipase A2 in Allergic Asthma: Transcriptional Regulation by TNF-α in Bronchoepithelial Cells, Justin S. Bickford, Kimberly J. Newsom, John-David Herlihy, Christian Mueller, Benjamin Keeler, Xiaolei Qiu, Jewell N. Walters, Nan Su, Shannon M. Wallet, Terence R. Flotte, and Harry S. Nick

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Gene transfer in the lung using recombinant adeno-associated virus, Alisha Gruntman, Christian Mueller, Terence R. Flotte, and Guangping Gao

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rAAV9 airway delivery results in effective knockdown of mutant alpha 1-antitrypsin in the liver while upregulating wildtype alpha 1-antitrypsin in the lung, Alisha Gruntman, Christian Mueller, Qiushi Tang, Lina Song, James M. Wilson, Terence R. Flotte, and Maria P. Limberis

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Long-term correction of very long-chain acyl-coA dehydrogenase deficiency in mice using AAV9 gene therapy, Allison M. Keeler, Thomas J. Conlon, Glenn Walter, Huadong Zeng, Scott A. Shaffer, Fu Dungtao, Kirsten E. Erger, Travis L. Cossette, Qiushi Tang, Christian Mueller, and Terence R. Flotte

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Cell and gene therapy for genetic diseases: inherited disorders affecting the lung and those mimicking sudden infant death syndrome, Allison M. Keeler and Terence R. Flotte

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Codon Optimization for Alpha 1-Antitrypsin Disease, Timothy Menz, Qiushi Tang, Lina Song, Christian Mueller, and Terence R. Flotte

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Sustained miRNA-mediated Knockdown of Mutant AAT With Simultaneous Augmentation of Wild-type AAT Has Minimal Effect on Global Liver miRNA Profiles, Christian Mueller, Qiushi Tang, Alisha Gruntman, Keith S. Blomenkamp, Jeffrey H. Teckman, Lina Song, Phillip D. Zamore, and Terence R. Flotte

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Production and discovery of novel recombinant adeno-associated viral vectors, Christian Mueller, Li Zhong, Dmitry Ratner, Miguel Sena-Esteves, and Guangping Gao

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A patient with asthma seeks medical advice, Brian P. O'Sullivan, Robert G. Zwerdling, and Ted M. Kremer

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A multi-center controlled trial of growth hormone treatment in children with cystic fibrosis, Michael S. Stalvey, Ran D. Anbar, Michael W. Konstan, Joan R. Jacobs, Bert Bakker, Barbara Lippe, and David E. Geller

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Long-term, efficient inhibition of microRNA function in mice using rAAV vectors, Jun Xie, Stefan L. Ameres, Randall H. Friedline, Jui-Hung Hung, Yu Zhang, Qing Xie, Li Zhong, Qin Su, Ran He, Mengxin Li, Huapeng Li, Xin Mu, Hongwei Zhang, Jennifer A. Broderick, Jason K. Kim, Zhiping Weng, Terence R. Flotte, Phillip D. Zamore, and Guangping Gao

Publications from 2011

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Preclinical evaluation of a recombinant adeno-associated virus vector expressing human alpha-1 antitrypsin made using a recombinant herpes simplex virus production method, Jeffrey D. Chulay, Guo-Jie Ye, Darby L. Thomas, David R. Knop, Janet M. Benson, Julie A. Hutt, Gensheng Wang, Margaret Humphries, and Terence R. Flotte

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The role of gene and cell therapy in the era of health care reform, Walter H. Ettinger and Terence R. Flotte

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Sendai virus vectors. Pushing the envelope in the lung, Terence R. Flotte

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Phase 2 clinical trial of a recombinant adeno-associated viral vector expressing α1-antitrypsin: interim results, Terence R. Flotte, Bruce C. Trapnell, Margaret Humphries, Brenna Carey, Roberto Calcedo, Farshid Rouhani, Martha Campbell-Thompson, Anthony T. Yachnis, Robert A. Sandhaus, Noel G. McElvaney, Christian Mueller, Louis M. Messina, James M. Wilson, Mark L. Brantly, David R. Knop, Guo-jie Ye, and Jeffrey D. Chulay

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No immune responses by the expression of the yeast Ndi1 protein in rats, Mathieu Marella, Byoung Boo Seo, Terence R. Flotte, Akemi Matsuno-Yagi, and Takao Yagi

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N-glycosylation augmentation of the cystic fibrosis epithelium improves Pseudomonas aeruginosa clearance, Ashley T. Martino, Christian Mueller, Sofia Braag, Pedro E. Cruz, Martha Campbell-Thompson, Shouguang Jin, and Terence R. Flotte

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Lack of cystic fibrosis transmembrane conductance regulator in CD3+ lymphocytes leads to aberrant cytokine secretion and hyperinflammatory adaptive immune responses, Christian Mueller, Sofia A. Braag, Allison M. Keeler, Craig Hodges, Mitchell Drumm, and Terence R. Flotte

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Hepatocyte-specific hypoxia-inducible factor-1alpha is a determinant of lipid accumulation and liver injury in alcohol-induced steatosis in mice, Bharath D. Nath, Ivan Levin, Timea Csak, Jan Petrasek, Christian Mueller, Karen Kodys, Donna Catalano, Pranoti Mandrekar, and Gyongyi Szabo

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Using hyperpolarized 3He MRI to evaluate treatment efficacy in cystic fibrosis patients, Yanping Sun, Brian P. O'Sullivan, John P. Roche, Ronn P. Walvick, Austin Reno, Dawn Baker, Joey Mansour, and Mitchell Albert

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MicroRNA-regulated, systemically delivered rAAV9: a step closer to CNS-restricted transgene expression, Jun Xie, Qing Xie, Hongwei Zhang, Stefan L. Ameres, Jui-Hung Hung, Qin Su, Ran He, Xin Mu, Seemin Seher Ahmed, Soyeon Park, Hiroki Kato, Chengjian Li, Christian Mueller, Craig C. Mello, Zhiping Weng, Terence R. Flotte, Phillip D. Zamore, and Guangping Gao

Publications from 2010

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IL-10 delivery by AAV5 vector attenuates inflammation in mice with Pseudomonas pneumonia, S. M. Buff, H. Yu, J. N. McCall, S. M. Caldwell, T. W. Ferkol, Terence R. Flotte, and I. L. Virella-Lowell

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Dual reporter comparative indexing of rAAV pseudotyped vectors in chimpanzee airway, Terence R. Flotte, Anne C. Fischer, Jason Goetzmann, Christian Mueller, Liudmila Cebotaru, Ziying Yan, Lilli Wang, James M. Wilson, William B. Guggino, and John F. Engelhardt

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Cystic fibrosis newborn screening: using experience to optimize the screening algorithm, Jaime E. Hale, Richard B. Parad, Henry L. Dorkin, Robert Gerstle, Allen Lapey, Brian P. O'Sullivan, L. Terry Spencer, William Yee, and Anne Marie Comeau

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Characterization of a recombinant adeno-associated virus type 2 Reference Standard Material, Martin Lock, Susan McGorray, Alberto Auricchio, Eduard Ayuso, E. Jeffrey Beecham, Veronique Blouin-Tavel, Fatima Bosch, Mahuya Bose, Barry J. Bryne, Tina Caton, John A. Chiorini, Abdelwahed Chtarto, K. Reed Clark, Thomas Conlon, Christophe Darmon, Monica Doria, Anne Douar, Terence R. Flotte, Joyce D. Francis, Achille Francois, Mauro Giacca, Michael T. Korn, Irina Korytov, Xavier Leon, Barbara Leuchs, Gabriele Lux, Catherine Melas, Hiroaki Mizukami, Philippe Moullier, Marcus Muller, Keiya Ozawa, Tina Philipsberg, Karine Poulard, Christina Raupp, Christel Riviere, Sigrid D. Roosendaal, Richard Jude Samulski, Steven M. Soltys, Richard Surosky, Liliane Tenenbaum, Darby L. Thomas, Bart van Montfort, Gabor Veres, J. Fraser Wright, Yili Xu, Olga Zelenaia, Lorena Zentilin, and Richard O. Snyder

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Autoimmunity in a genetic disease-a cautionary tale, Melissa J. Moore and Terence R. Flotte

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Modulation of Exaggerated-IgE Allergic Responses by Gene Transfer-mediated Antagonism of IL-13 and IL-17e., Christian Mueller, Allison M. Keeler, Sofia Braag, Timothy Menz, Qiushi Tang, and Terence R. Flotte

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In vitro and in vivo functional characterization of gutless recombinant SV40-derived CFTR vectors, Christian Mueller, M. S. Strayer, Jeffrey Sirninger, Sofia A. Braag, Francisco Branco, Jean-Pierre Louboutin, Terence R. Flotte, and David S. Strayer

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Cystic Fibrosis: Diagnosis, Sweat Testing, and Newborn Screening, Brian P. O'Sullivan

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Inhaled aztreonam, Brian P. O'Sullivan, Uma Yasothan, and Peter Kirkpatrick

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Cystic Fibrosis, Michael S. Stalvey, Christian Mueller, and Terence R. Flotte

Publications from 2009

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Sustained transgene expression despite T lymphocyte responses in a clinical trial of rAAV1-AAT gene therapy, Mark L. Brantly, Jeffrey D. Chulay, Lili Wang, Christian Mueller, Margaret Humphries, L. Terry Spencer, Farshid Rouhani, Thomas J. Conlon, Roberto Calcedo, Michael R. Betts, Carolyn Spencer, Barry J. Bryne, James M. Wilson, and Terence R. Flotte

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Oropharyngeal flora in healthy infants: observations and implications for cystic fibrosis care, David Carlson, Elizabeth McKeen, Michael Mitchell, Brenda B. Torres, Richard B. Parad, Anne Marie Comeau, and Brian P. O'Sullivan

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Cystic fibrosis pulmonary guidelines: airway clearance therapies, Patrick A. Flume, Karen A. Robinson, Brian P. O'Sullivan, Jonathan D. Finder, Robert L. Vender, Donna-Beth Willey-Courand, Terry B. White, and Bruce C. Marshall

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Recombinant AAV serotype and capsid mutant comparison for pulmonary gene transfer of alpha-1-antitrypsin using invasive and noninvasive delivery, Rejean Liqun Wang, Thomas J. McLaughlin, Travis Cossette, Qiushi Tang, Kevin Foust, Martha Campbell-Thompson, Ashley Martino, Pedro Cruz, Scott A. Loiler, Christian Mueller, and Terence R. Flotte

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The pros and cons of immunomodulatory IL-10 gene therapy with recombinant AAV in a Cftr-/- -dependent allergy mouse model, Christian Mueller, Sofia A. Braag, A. T. Martino, Qiushi Tang, M. Campbell-Thompson, and Terence R. Flotte

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The clinical approach to lung disease in patients with cystic fibrosis, Brian P. O'Sullivan and Patrick Flume

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Cystic fibrosis, Brian P. O'Sullivan and Steven D. Freedman

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Pulmonary Manifestations of Systemic Vasculitis, Brian P. O'Sullivan and Ted M. Kremer

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Murine model for cystic fibrosis bone disease demonstrates osteopenia and sex-related differences in bone formation, Troy D. Pashuck, Sarah E. Franz, Molly K. Altman, Clive H. Wasserfall, Mark A. Atkinson, Thomas J. Wronski, Terence R. Flotte, and Michael S. Stalvey

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Endocrine parameters of cystic fibrosis: back to basics, Michael S. Stalvey and Terence R. Flotte

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Defective acid sphingomyelinase pathway with Pseudomonas aeruginosa infection in cystic fibrosis, Hong Yu, Youssef H. Zeidan, Bill X. Wu, Russell W. Jenkins, Terence R. Flotte, Yusuf A. Hannun, and Isabel Virella-Lowell

Publications from 2008

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Biochemical correction of short-chain acyl-coenzyme A dehydrogenase deficiency after portal vein injection of rAAV8-SCAD, Stuart G. Beattie, Eric Goetzman, Thomas Conlon, Sean Germain, Glenn Walter, Martha Campbell-Thompson, Dietrich Matern, Jerry Vockley, and Terence R. Flotte

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Recombinant adeno-associated virus-mediated gene delivery of long chain acyl coenzyme A dehydrogenase (LCAD) into LCAD-deficient mice, Stuart G. Beattie, Eric Goetzman, Qiushi Tang, Thomas Conlon, Martha Campbell-Thompson, Dietrich Matern, Jerry Vockley, and Terence R. Flotte

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Cystic fibrosis transmembrane regulator missing the first four transmembrane segments increases wild type and DeltaF508 processing, Liudmila Cebotaru, Neerag Vij, Igor Ciobanu, Jerry Wright, Terence R. Flotte, and William B. Guggino

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Human gene therapy for RPE65 isomerase deficiency activates the retinoid cycle of vision but with slow rod kinetics, Artur V. Cideciyan, Tomas S. Aleman, Sanford L. Boye, Sharon B. Schwartz, Shalesh Kaushal, Alejandro J. Roman, Ji-Jing Pang, Alexander Sumaroka, Elizabeth A. M. Windsor, James M. Wilson, Terence R. Flotte, Gerald A. Fishman, Elise Heon, Edwin M. Stone, Barry J. Bryne, Samuel G. Jacobson, and William W. Hauswirth

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In utero efficacy of cystic fibrosis gene therapy: difficult studies, positive or negative, Terence R. Flotte

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Apparently nonspecific enzyme elevations after portal vein delivery of recombinant adeno-associated virus serotype 2 vector in hepatitis C virus-infected chimpanzees, Terence R. Flotte, Jason Goetzmann, James Caridi, Joseph Paolillo, Thomas J. Conlon, Mark Potter, Christian Mueller, and Barry J. Bryne

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Recombinant adeno-associated virus-mediated global anterograde delivery of glial cell line-derived neurotrophic factor to the spinal cord: comparison of rubrospinal and corticospinal tracts in the rat, Kevin D. Foust, Terence R. Flotte, Paul J. Reier, and Ronald J. Mandel

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Neonatal intraperitoneal or intravenous injections of recombinant adeno-associated virus type 8 transduce dorsal root ganglia and lower motor neurons, Kevin D. Foust, Amy Poirier, Christina A. Pacak, Ronald J. Mandel, and Terence R. Flotte

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Treatment of leber congenital amaurosis due to RPE65 mutations by ocular subretinal injection of adeno-associated virus gene vector: short-term results of a phase I trial, William W. Hauswirth, Tomas S. Aleman, Shalesh Kaushal, Artur V. Cideciyan, Sharon B. Schwartz, Lili Wang, Thomas J. Conlon, Sanford L. Boye, Terence R. Flotte, Barry J. Bryne, and Samuel G. Jacobson

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Intensive care management of the patient with cystic fibrosis, Ted M. Kremer, Robert G. Zwerdling, Peter H. Michelson, and Brian P. O'Sullivan

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Clinical gene therapy using recombinant adeno-associated virus vectors, Christian Mueller and Terence R. Flotte

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Gene therapy for cystic fibrosis, Christian Mueller and Terence R. Flotte

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Partial correction of the CFTR-dependent ABPA mouse model with recombinant adeno-associated virus gene transfer of truncated CFTR gene, Christian Mueller, Daniel M. Torrez, Sofia Braag, Ashley Martino, Tracy Clarke, Martha Campbell-Thompson, and Terence R. Flotte

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By the sweat of our brows: how salty should a person be, Brian P. O'Sullivan and Robert G. Zwerdling

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Towards a rAAV-based gene therapy for ADA-SCID: from ADA deficiency to current and future treatment strategies, Jared N. Silver and Terence R. Flotte

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CFTR mutations impart elevated immune reactivity in a murine model of cystic fibrosis related diabetes, Michael S. Stalvey, Todd M. Brusko, Christian Mueller, Clive H. Wasserfall, Desmond A. Schatz, Mark A. Atkinson, and Terence R. Flotte

Publications from 2007

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Progress and prospects: gene therapy clinical trials (part 1), B. L. Alexander, R. R. Ali, E.W.F. Alton, J. W. Bainbridge, S. Braun, S. H. Cheng, Terence R. Flotte, H. B. Gaspar, M. Grez, U. Griesenbach, M. G. Kaplitt, M. G. Ott, R. Seger, M. Simons, A. Z. Thrasher, and S. Yla-Herttuala

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Potential utility of plasma fatty acid analysis in the diagnosis of cystic fibrosis, Ibrahim Batal, Mhd-Bassel Ericsoussi, Joanne E. Cluette-Brown, Brian P. O'Sullivan, Steven D. Freedman, Juanito E. Savaille, and Michael Laposata

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Adeno-associated viral vector-mediated interleukin-10 prolongs allograft survival in a rat kidney transplantation model, B. Chen, M. H. Kapturczak, R. Joseph, J. F. George, M. Campbell-Thompson, Clive H. Wasserfall, Mark A. Atkinson, C. C. Tisher, Terence R. Flotte, A. Argarwal, and S. Chen

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Guidelines for implementation of cystic fibrosis newborn screening programs: Cystic Fibrosis Foundation workshop report, Anne Marie Comeau, Frank J. Accurso, Terry B. White, Preston W. Campbell, Gary Hoffman, Richard B. Parad, Benjamin S. Wilfond, Margaret Rosenfeld, Marci K. Sontag, John H. Massie, Philip M. Farrell, and Brian P. O'Sullivan

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In vivo post-transcriptional gene silencing of alpha-1 antitrypsin by adeno-associated virus vectors expressing siRNA, Pedro E. Cruz, Christian Mueller, Travis L. Cossette, Alexandra Golant, Qiushi Tang, Stuart G. Beattie, Mark Brantly, Martha Campbell-Thompson, Keith S. Blomenkamp, Jeffrey H. Teckman, and Terence R. Flotte

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The promise of gene therapy for the treatment of alpha-1 antitrypsin deficiency, Pedro E. Cruz, Christian Mueller, and Terence R. Flotte

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In vivo expression of human ATP:cob(I)alamin adenosyltransferase (ATR) using recombinant adeno-associated virus (rAAV) serotypes 2 and 8, Kirsten E. Erger, Thomas J. Conlon, Nicole A. Leal, Robert Zori, Thomas A. Bobik, and Terence R. Flotte

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Gene therapy: the first two decades and the current state-of-the-art, Terence R. Flotte

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Cystic fibrosis pulmonary guidelines: chronic medications for maintenance of lung health, Patrick A. Flume, Brian P. O'Sullivan, Karen A. Robinson, Christopher H. Goss, Peter J. Mogayzel Jr., Donna Beth Willey-Courand, Janet Bujan, Jonathan Finder, Mary Lester, Lynne Quittell, Randall Rosenblatt, Robert L. Vender, Leslie Hazle, Kathy Sabadosa, and Bruce Marshall

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Cystic fibrosis heterozygotes do not have increased platelet activation, Inge Tarnow, Alan D. Michelson, Andrew L. Frelinger III, Matthew Dean Linden, YouFu Li, Marsha L. Fox, Marc R. Barnard, and Brian P. O'Sullivan

Publications from 2006

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Enhanced IgE allergic response to Aspergillus fumigatus in CFTR-/- mice, Christian Mueller, Sofia A. Braag, John-David Herlihy, Clive H. Wasserfall, Sarah E. Chesrown, Harry S. Nick, Mark A. Atkinson, and Terence R. Flotte

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The inflammatory role of platelets in cystic fibrosis, Brian P. O'Sullivan and Alan D. Michelson

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Early pulmonary manifestation of cystic fibrosis in children with the DeltaF508/R117H-7T genotype, Brian P. O'Sullivan, Robert G. Zwerdling, Henry L. Dorkin, Anne Marie Comeau, and Richard B. Parad

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Cystic fibrosis transmembrane conductance regulator deficiency exacerbates islet cell dysfunction after beta-cell injury, Michael S. Stalvey, Christian Mueller, Desmond A. Schatz, Clive H. Wasserfall, Martha L. Campbell-Thompson, Douglas W. Theriaque, Terence R. Flotte, and Mark A. Atkinson

Publications from 2005

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Communications systems and their models: Massachusetts parent compliance with recommended specialty care after positive cystic fibrosis newborn screening result, Anne Marie Comeau, Richard B. Parad, Robert Gerstle, Brian P. O'Sullivan, Henry L. Dorkin, Mark Dovey, Kenan Haver, Thomas Martin, and Roger B. Eaton

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Frequency of laboratory test utilization in the intensive care unit and its implications for large-scale data collection efforts, Joseph J. Frassica

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Platelet activation in cystic fibrosis, Brian P. O'Sullivan, Matthew D. Linden, Andrew L. Frelinger III, Marc R. Barnard, Michele Spencer-Manzon, James E. Morris, Raneem O. Salem, Michael Laposata, and Alan D. Michelson

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Sweat testing infants detected by cystic fibrosis newborn screening, Richard B. Parad, Anne Marie Comeau, Henry L. Dorkin, Mark Dovey, Robert Gerstle, Thomas Martin, and Brian P. O'Sullivan

Publications from 2004

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Population-based newborn screening for genetic disorders when multiple mutation DNA testing is incorporated: a cystic fibrosis newborn screening model demonstrating increased sensitivity but more carrier detections, Anne Marie Comeau, Richard B. Parad, Henry L. Dorkin, Mark Dovey, Robert Gerstle, Kenan Haver, Allen Lapey, Brian P. O'Sullivan, David A. Waltz, Robert G. Zwerdling, and Roger B. Eaton

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Frequency of laboratory test utilization in the intensive care unit and its implications for large scale data collection efforts, Joseph J. Frassica