Delivery of Adeno-Associated Virus Gene Therapy by Intravascular Limb Infusion Methods

UMMS Affiliation

Department of Pediatrics, Division of Pulmonary and Allergy; Gene Therapy Center



Document Type



Genetics and Genomics | Therapeutics


Recombinant adeno-associated virus (rAAV) can be delivered to the skeletal muscle of the limb (pelvic or thoracic) by means of regional intravascular delivery. This review summarizes the evolution of this technique to deliver rAAV either via the arterial blood supply or via the peripheral venous circulation. The focus of this review is on applications in large animal models, including preclinical studies. Based on this overview of past research, we aim to inform the design of preclinical and clinical studies.

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Citation: Hum Gene Ther Clin Dev. 2015 Sep;26(3):159-64. doi: 10.1089/humc.2015.116. Epub 2015 Sep 10. Link to article on publisher's site

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Link to Article in PubMed

PubMed ID