Phagocyte nicotinamide adenine dinucleotide phosphate oxidase activity in patients with inherited IFN-gammaR1 or IFN-gammaR2 deficiency
Department of Pediatrics, Division of Hematology/Oncology
Bacterial Infections and Mycoses | Immunology and Infectious Disease | Infectious Disease | Pediatrics
An understanding of protective immunity to mycobacterial infection is critical for the development of effective strategies to control tuberculosis (TB), a major public health problem worldwide. Mendelian susceptibility to mycobacterial disease (MSMD) is a rare condition characterized by clinical disease caused by weakly virulent mycobacteria, such as Mycobacterium bovis Bacille Calmette-Guérin (BCG) vaccines and nontuberculous, environmental mycobacteria (EM) (OMIM209950). ... We therefore tested the hypothesis that the function of the NADPH oxidase complex might be partly dependent on IFN-γ, at least in human MDMs in vitro.
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Citation: J Allergy Clin Immunol. 2015 May;135(5):1393-5.e1. doi:10.1016/j.jaci.2014.11.004. Epub 2014 Dec 24. Link to article on publisher's site
Conti, Francesca; Aragao-Filho, Walmir Cutrim; Prando, Carolina; Deswarte, Caroline; Hubeau, Marjorie; Newburger, Peter E.; Casanova, Jean-Laurent; Bustamante, Jacinta; and Condino-Neto, Antonio, "Phagocyte nicotinamide adenine dinucleotide phosphate oxidase activity in patients with inherited IFN-gammaR1 or IFN-gammaR2 deficiency" (2015). Pediatric Publications and Presentations. 39.