Title

Phagocyte nicotinamide adenine dinucleotide phosphate oxidase activity in patients with inherited IFN-gammaR1 or IFN-gammaR2 deficiency

UMMS Affiliation

Department of Pediatrics, Division of Hematology/Oncology

Date

5-1-2015

Document Type

Article

Disciplines

Bacterial Infections and Mycoses | Immunology and Infectious Disease | Infectious Disease | Pediatrics

Abstract

An understanding of protective immunity to mycobacterial infection is critical for the development of effective strategies to control tuberculosis (TB), a major public health problem worldwide. Mendelian susceptibility to mycobacterial disease (MSMD) is a rare condition characterized by clinical disease caused by weakly virulent mycobacteria, such as Mycobacterium bovis Bacille Calmette-Guérin (BCG) vaccines and nontuberculous, environmental mycobacteria (EM) (OMIM209950). ... We therefore tested the hypothesis that the function of the NADPH oxidase complex might be partly dependent on IFN-γ, at least in human MDMs in vitro.

Rights and Permissions

Citation: J Allergy Clin Immunol. 2015 May;135(5):1393-5.e1. doi:10.1016/j.jaci.2014.11.004. Epub 2014 Dec 24. Link to article on publisher's site

Related Resources

Link to Article in PubMed

PubMed ID

25542884