Impaired generation of hepatitis B virus-specific memory B cells in HIV infected individuals following vaccination

Nishaki Mehta, University of Massachusetts Medical School
Colleen K. Cunningham, Syracuse University
Patricia M. Flynn, St. Jude Children's Research Hospital
Joyce A. Pepe, University of Massachusetts Medical School
Stephen Obaro, Michigan State University
Bill G. Kapogiannis, National Institutes of Health
James Bethel, Westat
Katherine Luzuriaga, University of Massachusetts Medical School

Abstract

Hepatitis B-specific memory B cell (HSMBC) frequencies were measured following hepatitis B vaccination in 15 HIV uninfected and 12 HIV infected adolescents. HSMBC were detected at significantly lower frequencies in HIV infected than in HIV uninfected individuals. The detection of HBsAb >10mIU/ml at study week 28 was strongly associated with the detection of HSMBC and a direct correlation between HBsAb titers and HSMBC frequencies was observed. In HIV uninfected individuals, antibody titers >1000mIU/ml were associated with higher HSMC frequencies. Lower HSMBC frequencies, reduced memory B cell (MBC) proliferation, and altered B cell phenotypes were measured in viremic HIV infected individuals compared with aviremic HIV infected or HIV uninfected individuals.