L-transposition of the great arteries
Department of Pediatrics
Medical Subject Headings
Transposition of Great Vessels
Cardiology | Cardiovascular Diseases | Congenital, Hereditary, and Neonatal Diseases and Abnormalities | Pediatrics
Summary: Levo- or L-looped transposition of the great arteries (L-TGA) is a rare form of congenital heart disease characterized by atrioventricular and ventriculoarterial discordance. It is also commonly referred to as congenitally corrected TGA, double discordance, or ventricular inversion. L-TGA usually does not present with cyanosis unless there are associated cardiac defects. Isolated L-TGA is "physiologically corrected" because systemic deoxygenated venous blood returns to the pulmonary circulation and oxygenated pulmonary venous blood returns to the systemic circulation. Patients with L-TGA are at increased risk for heart failure as adults due to progressive decline in systemic right ventricular function. The pathophysiology, clinical features, diagnosis and management of L-TGA will be presented here.