UMMS Affiliation

Department of Pediatrics; Department of Biochemistry and Molecular Pharmacology; Imbalzano Lab; Nickerson Lab

Date

6-1-2017

Document Type

Article

Disciplines

Biochemistry, Biophysics, and Structural Biology | Cancer Biology | Cell Biology | Genetics and Genomics

Abstract

Mammalian SWI/SNF enzymes are ATP-dependent remodelers of chromatin structure. These multisubunit enzymes are heterogeneous in composition; there are two catalytic ATPase subunits, BRM and BRG1, that are mutually exclusive, and additional subunits are incorporated in a combinatorial manner. Recent findings indicate that approximately 20% of human cancers contain mutations in SWI/SNF enzyme subunits, leading to the conclusion that the enzyme subunits are critical tumor suppressors. However, overexpression of specific subunits without apparent mutation is emerging as an alternative mechanism by which cellular transformation may occur. Here we highlight recent evidence linking elevated expression of the BRG1 ATPase to tissue-specific cancers and work suggesting that inhibiting BRG1 may be an effective therapeutic strategy.

Rights and Permissions

© Anthony N. Imbalzano. Citation: Epigenomics. 2017 Jun;9(6):919-931. doi: 10.2217/epi-2017-0034. Epub 2017 May 19. Link to article on publisher's site

Related Resources

Link to Article in PubMed

Keywords

ADAADi, BRG1, BRM, PFI-3, breast cancer, cancer metabolism, chromatin remodeling, drug transporters, mammalian SWI/SNF enzymes

PubMed ID

28521512

Creative Commons License

Creative Commons Attribution 4.0 License
This work is licensed under a Creative Commons Attribution 4.0 License.

 
 

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