The BRG1 ATPase of human SWI/SNF chromatin remodeling enzymes as a driver of cancer
Authors
Wu, QiongLian, Jane B.
Stein, Janet L.
Stein, Gary S.
Nickerson, Jeffrey A.
Imbalzano, Anthony N.
UMass Chan Affiliations
Nickerson LabImbalzano Lab
Department of Biochemistry and Molecular Pharmacology
Department of Pediatrics
Document Type
Journal ArticlePublication Date
2017-06-01Keywords
ADAADiBRG1
BRM
PFI-3
breast cancer
cancer metabolism
chromatin remodeling
drug transporters
mammalian SWI/SNF enzymes
Biochemistry, Biophysics, and Structural Biology
Cancer Biology
Cell Biology
Genetics and Genomics
Metadata
Show full item recordAbstract
Mammalian SWI/SNF enzymes are ATP-dependent remodelers of chromatin structure. These multisubunit enzymes are heterogeneous in composition; there are two catalytic ATPase subunits, BRM and BRG1, that are mutually exclusive, and additional subunits are incorporated in a combinatorial manner. Recent findings indicate that approximately 20% of human cancers contain mutations in SWI/SNF enzyme subunits, leading to the conclusion that the enzyme subunits are critical tumor suppressors. However, overexpression of specific subunits without apparent mutation is emerging as an alternative mechanism by which cellular transformation may occur. Here we highlight recent evidence linking elevated expression of the BRG1 ATPase to tissue-specific cancers and work suggesting that inhibiting BRG1 may be an effective therapeutic strategy.Source
Epigenomics. 2017 Jun;9(6):919-931. doi: 10.2217/epi-2017-0034. Epub 2017 May 19. Link to article on publisher's siteDOI
10.2217/epi-2017-0034Permanent Link to this Item
http://hdl.handle.net/20.500.14038/43585PubMed ID
28521512Related Resources
Link to Article in PubMedRights
© Anthony N. Imbalzano.Distribution License
http://creativecommons.org/licenses/by/4.0/ae974a485f413a2113503eed53cd6c53
10.2217/epi-2017-0034