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Authors
Burns, Jane S.Williams, Paige L.
Lee, Mary M.
Revich, Boris
Sergeyev, Oleg
Hauser, Russ
Korrick, Susan A.
UMass Chan Affiliations
Department of Pediatrics, Division of Pediatric EndocrinologyDocument Type
Journal ArticlePublication Date
2017-09-01Keywords
Body mass indexChildhood growth
Children
Height
Lead
Metals
Endocrinology, Diabetes, and Metabolism
Environmental Public Health
Medical Toxicology
Pediatrics
Physiological Processes
Metadata
Show full item recordAbstract
BACKGROUND: Childhood blood lead levels (BLL) have been associated with growth impairment. OBJECTIVES: We assessed associations of peripubertal BLL with adolescent growth and near adult height in a longitudinal cohort of Russian boys. METHODS: 481 boys were enrolled at ages 8-9years and followed annually to age 18. At enrollment, BLL was measured, and height, weight, and pubertal staging were obtained annually during 10years of follow-up. Mixed effects models were used to assess the associations of BLL with longitudinal age-adjusted World Health OrganizationZ-scores for height (HT-Z) and body mass index (BMI-Z), and annual height velocity (HV). Interactions between boys' age and BLL on growth outcomes were evaluated. RESULTS: The median (range) BLL was 3.0 (0.5-31.0) mug/dL. At age 18years, 79% of boys had achieved near adult height (HV < 1.0cm/year), and means (SD) for HT-Z and BMI-Z were 0.15 (0.92) and -0.32 (1.24). Over 10years of follow-up, after covariate adjustment, boys with higher ( > /=5mug/dL) BLL compared with lower BLL were shorter (adjusted mean difference in HT-Z=-0.43, 95% CI -0.60, -0.25, p-value < 0.001), translating to a 2.5cm lower height at age 18years. The decrement in height for boys with higher BLL was most pronounced at 12 to 15years of age (interaction p=0.03). Boys with higher BLL were leaner (adjusted mean difference in BMI-Z=-0.22, 95% CI: -0.45, 0.01, p=0.06). CONCLUSIONS: Higher peripubertal BLLs were associated with shorter height through age 18years, suggesting a persistent effect of lead on linear growth.Source
Environ Int. 2017 Sep;106:53-59. doi: 10.1016/j.envint.2017.05.023. Epub 2017 Jun 7. Link to article on publisher's siteDOI
10.1016/j.envint.2017.05.023Permanent Link to this Item
http://hdl.handle.net/20.500.14038/43584PubMed ID
28599171Related Resources
Link to Article in PubMedae974a485f413a2113503eed53cd6c53
10.1016/j.envint.2017.05.023