Absence of hippocampal sclerosis in children with multiple daily seizures since infancy

UMMS Affiliation

Department of Pediatrics; Department of Pathology



Document Type


Medical Subject Headings

Child; Child, Preschool; Electroencephalography; Epilepsy, Temporal Lobe; Hippocampus; Humans; Infant; Magnetic Resonance Imaging; Neurosurgical Procedures; Periodicity; Retrospective Studies; Sclerosis; Temporal Lobe


Neurology | Pathology | Pediatrics


We report a series of nine children with multiple daily seizures since infancy who underwent functional hemispherectomy that included en bloc resection of the hippocampus and the temporal neocortex. In all cases, the hippocampi were normal by conventional histology despite the fact that these patients had suffered from recurrent seizures over a long period of time. This observation suggests that extremely frequent seizures in childhood are not invariably associated with the development of hippocampal sclerosis.

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Citation: J Child Neurol. 2001 Aug;16(8):562-4. doi: 10.1177/088307380101600804

Related Resources

Link to Article in PubMed