Absence of hippocampal sclerosis in children with multiple daily seizures since infancy
Department of Pediatrics; Department of Pathology
Medical Subject Headings
Child; Child, Preschool; Electroencephalography; Epilepsy, Temporal Lobe; Hippocampus; Humans; Infant; Magnetic Resonance Imaging; Neurosurgical Procedures; Periodicity; Retrospective Studies; Sclerosis; Temporal Lobe
Neurology | Pathology | Pediatrics
We report a series of nine children with multiple daily seizures since infancy who underwent functional hemispherectomy that included en bloc resection of the hippocampus and the temporal neocortex. In all cases, the hippocampi were normal by conventional histology despite the fact that these patients had suffered from recurrent seizures over a long period of time. This observation suggests that extremely frequent seizures in childhood are not invariably associated with the development of hippocampal sclerosis.
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Citation: J Child Neurol. 2001 Aug;16(8):562-4. doi: 10.1177/088307380101600804
Kothare, Sanjeev V.; Sotrel, Ana; Duchowny, Michael; Jayakar, Prasanna; Marshall, Paul C.; and Smith, Thomas W., "Absence of hippocampal sclerosis in children with multiple daily seizures since infancy" (2001). Neurology. 11.