The platelet hyporeactivity of extremely low birth weight neonates is age-dependent
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UMass Chan Affiliations
Department of PediatricsDocument Type
Journal ArticlePublication Date
2009-05-01Keywords
Adult; Age Factors; Blood Platelets; Factor V; Factor Va; Humans; Infant, Extremely Low Birth Weight; Infant, Newborn; P-Selectin; Platelet Glycoprotein GPIb-IX ComplexPediatrics
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INTRODUCTION: We have previously demonstrated that, as compared to adults, the platelets of extremely low birth weight (ELBW) neonates are markedly hyporeactive on day 0-1 of life. The purpose of this study was to examine the age dependency of this hyporeactivity. MATERIALS AND METHODS: On days 0-1, 3-4, and 10-14, peripheral blood was collected from 14 stable ELBW neonates and compared to peripheral blood from normal adults run in parallel. Whole blood flow cytometry was used to examine the activation-dependent increase in platelet surface P-selectin (reflecting degranulation) and platelet surface binding of factor V/Va (reflecting platelet surface procoagulant activity) and decrease in platelet surface glycoprotein (GP) Ib (the von Willebrand factor receptor). RESULTS: In the physiologic milieu of whole blood, ELBW neonatal platelets on days 0-1 and 3-4 were markedly less reactive than adult platelets. However, by day 10-14, the platelet function of ELBW neonates improved significantly, although not completely to adult levels. CONCLUSIONS: The age-dependent platelet hyporeactivity of ELBW neonates demonstrated in this study may be a contributing factor to the similar age-dependent propensity of ELBW neonates to intraventricular hemorrhage.Source
Thromb Res. 2009 May;124(1):42-5. Epub 2008 Nov 20. Link to article on publisher's siteDOI
10.1016/j.thromres.2008.10.004Permanent Link to this Item
http://hdl.handle.net/20.500.14038/43501PubMed ID
19026437Related Resources
Link to Article in PubMedae974a485f413a2113503eed53cd6c53
10.1016/j.thromres.2008.10.004