Lack of alternative coreceptor use by pediatric HIV-1 R5 isolates for infection of primary cord or adult peripheral blood mononuclear cells
Authors
Sullivan, W. MatthewDorr, P.
Perros, M.
Hudson, Richard W. Jr.
Leif, Jean H.
Luzuriaga, Katherine
Clapham, Paul R.
UMass Chan Affiliations
Department of Molecular Genetics and MicrobiologyDepartment of Medicine, Division of Diabetes
Program in Molecular Medicine
Department of Pediatrics
Document Type
Journal ArticlePublication Date
2008-01-01Keywords
HIV InfectionsHIV Reverse Transcriptase
HIV-1
Humans
Infant
Infant, Newborn
Leukocytes, Mononuclear
Receptors, CCR5
Receptors, Virus
*Virus Internalization
Virus Replication
Immunology and Infectious Disease
Pediatrics
Metadata
Show full item recordAbstract
HIV-1 infection of neonates results in an extended acute period of virus replication, frequent neurological problems and reduced survival compared to adults. In adults, R5 viruses mainly infect CCR5(+) CD4(+) memory T-cells. In neonates, CCR5(+) memory T-cells form a substantially smaller fraction of total lymphocytes. We therefore tested whether alternative coreceptors confer infection of lymphocytes by pediatric isolates. Pediatric HIV-1 R5 isolates failed to replicate in Delta32/Delta32 CCR5 PBMCs or in cord PBMCs treated with a CCR5 inhibitor. These results do not indicate a role for alternative coreceptors and provide support for CCR5 inhibitors in the therapy of HIV-1(+) neonates.Source
Arch Virol. 2008;153(2):363-6. Epub 2007 Dec 13. Link to article on publisher's siteDOI
10.1007/s00705-007-1099-6Permanent Link to this Item
http://hdl.handle.net/20.500.14038/43478PubMed ID
18074097Related Resources
Link to Article in PubMedae974a485f413a2113503eed53cd6c53
10.1007/s00705-007-1099-6